The Korean Journal of Pain

The Korean Pain Society (대한통증학회)
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Effectiveness of Oral Glycopyrrolate Use in Compensatory Hyperhidrosis Patients

  • Gong, Tai Kyung (Department of Anesthesiology and Pain Medicine, Ajou University College of Medicine) ;
  • Kim, Do Wan (Department of Anesthesiology and Pain Medicine, Ajou University College of Medicine)
  • Received : 2012.11.12
  • Accepted : 2012.11.29
  • Published : 2013.01.01
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Abstract

Compensatory hyperhidrosis or reflex hyperhidrosis is the increase in sweating in the postoperative stage of thoracic sympathectomy or lumbar sympathectomy. It shares several features with anxiety disorders and has a negative impact on a patient's quality of life. Oralglycopyrrolate is one of the treatment options available. This study reviewed case notes in a series of 19 patients with compensatory hyperhidrosis. We made a comparison between the Milanez de Campos score of a pre-glycopyrrolate medication group and the Milanez de Campos score of a post-glycopyrrolate medication group. The Beck Depression Inventory (BDI) score, Beck Anxiety Inventory (BAI) score, and autonomic nervous system (ANS) scale score were also compared between the pre-medication and post-medication groups. In the post-glycopyrrolate medication group, there was decrease in the Milanez de Campos score, BAI score, and BDI score (P < 0.05). But no meaningful change was seen in the ANS score in the post-glycopyrrolate medication group (P > 0.05). Glycopyrrolate is an effective medication in the treatment of compensatory hyperhidrosis that, can alleviate anxiety and improve patients' quality of life.

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References

  1. Sato K, Kang WH, Saga K, Sato KT. Biology of sweat glands and their disorders. II. Disorders of sweat gland function. J Am Acad Dermatol 1989; 20: 713-26. https://doi.org/10.1016/S0190-9622(89)70081-5
  2. Kim WO, Yoon DM, Kil HK, Kim JI, Choi BI. Effect of oral glycopyrrolate in essential hyperhidrosis. Korean J Anesthesiol 2004; 46: 298-301. https://doi.org/10.4097/kjae.2004.46.3.298
  3. Lai YT, Yang LH, Chio CC, Chen HH. Complications in patients with palmar hyperhidrosis treated with transthoracic endoscopic sympathectomy. Neurosurgery 1997; 41: 110-3. https://doi.org/10.1097/00006123-199707000-00023
  4. Adar R, Kurchin A, Zweig A, Mozes M. Palmar hyperhidrosis and its surgical treatment: a report of 100 cases. Ann Surg 1977; 186: 34-41. https://doi.org/10.1097/00000658-197707000-00006
  5. Chou SH, Kao EL, Li HP, Lin CC, Huang MF. T4 sympathectomy for palmar hyperhidrosis: an effective approach that simultaneously minimzes compensatory hyperhidrosis. Kaohsiung J Med Sci 2005; 21: 310-3. https://doi.org/10.1016/S1607-551X(09)70126-3
  6. Fredman B, Zohar E, Shachor D, Bendahan J, Jedeikin R. Video-assisted transthoracic sympathectomy in the treatment of primary hyperhidrosis: friend or foe? Surg Laparosc Endosc Percutan Tech 2000; 10: 226-9.
  7. Lin TS, Wang NP, Huang LC. Pitfalls and complication avoidance associated with transthoracic endoscopic sympathectomy for primary hyperhidrosis (analysis of 2200 cases). Int J Surg Investig 2001; 2: 377-85.
  8. Gossot D, Galetta D, Pascal A, Debrosse D, Caliandro R, Girard P, et al. Long-term results of endoscopic thoracic sympathectomy for upper limb hyperhidrosis. Ann Thorac Surg 2003; 75: 1075-9. https://doi.org/10.1016/S0003-4975(02)04657-X
  9. Lin CC, Telaranta T. Lin-Telaranta classification: the importance of different procedures for different indications in sympathetic surgery. Ann Chir Gynaecol 2001; 90: 161-6.
  10. Lyra Rde M, Campos JR, Kang DW, Loureiro Mde P, Furian MB, Costa MG, et al. Guidelines for the prevention, diagnosis and treatment of compensatory hyperhidrosis. J Bras Pneumol 2008; 34: 967-77. https://doi.org/10.1590/S1806-37132008001100013
  11. de Campos JR, Wolosker N, Takeda FR, Kauffman P, Kuzniec S, Jatene FB, et al. The body mass index and level of resection: predictive factors for compensatory sweating after sympathectomy. Clin Auton Res 2005; 15: 116-20. https://doi.org/10.1007/s10286-005-0259-6
  12. Nascimento LP, Raffin RP, Guterres SS. Aspectos atuais sobre a segurança no uso de produtos antiperspirantes contendo derivados de aluminio. Infarma 2004; 16: 66-72.
  13. Guntinas-Lichius O. Increased botulinum toxin type A dosage is more effective in patients with Frey's syndrome. Laryngoscope 2002; 112: 746-9. https://doi.org/10.1097/00005537-200204000-00027
  14. Naumann M. Evidence-based medicine: botulinum toxin in focal hyperhidrosis. J Neurol 2001; 248 Suppl 1: 31-3. https://doi.org/10.1007/PL00007817

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