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Actoprotective effect of ginseng: improving mental and physical performance

  • Oliynyk, Sergiy (Department of Neuroscience and Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University) ;
  • Oh, Seikwan (Department of Neuroscience and Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University)
  • Received : 2012.11.01
  • Accepted : 2012.12.12
  • Published : 2013.04.15

Abstract

Actoprotectors are preparations that increase the mental performance and enhance body stability against physical loads without increasing oxygen consumption. Actoprotectors are regarded as a subclass of adaptogens that hold a significant capacity to increase physical performance. The focus of this article is studying adaptogen herbs of genus Panax (P. ginseng in particular) and their capabilities as actoprotectors. Some animal experiments and human studies about actoprotective properties of genus Panax attest that P. ginseng (administered as an extract) significantly increased the physical and intellectual work capacities, and the data provided suggests that ginseng is a natural source of actoprotectors. Preparations of ginseng can be regarded as potential actoprotectors which give way to further research of its influence on physical and mental work capacity, endurance and restoration after exhaustive physical loads while compared with reference actoprotectors.

Keywords

References

  1. Oliynyk SA, Gunina LM, Seifulla RD. Pharmacology of sports. Kyiv: Olimpiyskaya Literatura, 2010.
  2. Oliynyk S, Oh S. The pharmacology of actoprotectors: practical application for improvement of mental and physical performance. Biomol Ther 2012;20:444-455.
  3. Gavreev AI, Marysheva VV, Shabanov PD. The actoprotective action of thiazoloindole antihypoxic agents. Eksp Klin Farmakol 2010;73:25-30.
  4. Iasnetsov VV, Tsublova EG, Iasnetsov VV, Karsanova SK, Skachilova SIa. Actiprotective and antihypoxic action of new heteroaromatic antioxidants. Aviakosm Ekolog Med 2011;45:51-54.
  5. Kurochka AV, Agafonova OV, Losev AS, Mamaeva EA, Bylikin SY, Negrebetsky VV, Kramarova EP, Shipov AG, Baukov YI. Six- and seven-membered 1-oxa-4-aza-2-silacyclanes as possible correctors of adaptational mechanisms. Met Based Drugs 1998;5:25-33. https://doi.org/10.1155/MBD.1998.25
  6. Panossian A, Wikman G. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity. Curr Clin Pharmacol 2009;4:198-219. https://doi.org/10.2174/157488409789375311
  7. Panossian AG, Oganessian AS, Ambartsumian M, Gabrielian ES, Wagner H, Wikman G. Effects of heavy physical exercise and adaptogens on nitric oxide content in human saliva. Phytomedicine 1999;6:17-26. https://doi.org/10.1016/S0944-7113(99)80030-0
  8. Panossian A, Wagner H. Stimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administration. Phytother Res 2005;19:819-838. https://doi.org/10.1002/ptr.1751
  9. Kuo J, Chen KW, Cheng IS, Tsai PH, Lu YJ, Lee NY. The effect of eight weeks of supplementation with Eleutherococcus senticosus on endurance capacity and metabolism in human. Chin J Physiol 2010;53:105-111. https://doi.org/10.4077/CJP.2010.AMK018
  10. Aslanyan G, Amroyan E, Gabrielyan E, Nylander M, Wikman G, Panossian A. Double-blind, placebo-controlled, randomised study of single dose effects of ADAPT-232 on cognitive functions. Phytomedicine 2010;17:494-499. https://doi.org/10.1016/j.phymed.2010.02.005
  11. Mendes FR, Carlini EA. Brazilian plants as possible adaptogens: an ethnopharmacological survey of books edited in Brazil. J Ethnopharmacol 2007;109:493-500. https://doi.org/10.1016/j.jep.2006.08.024
  12. Azizov AP, Seifulla RD. The effect of elton, leveton, fitoton and adapton on the work capacity of experimental animals. Eksp Klin Farmakol 1998;61:61-63.
  13. Zhang GL, Deng JP, Wang BH, Zhao ZW, Li J, Gao L, Liu BL, Xong JR, Guo XD, Yan ZQ et al. Gypenosides improve cognitive impairment induced by chronic cerebral hypoperfusion in rats by suppressing oxidative stress and astrocytic activation. Behav Pharmacol 2011;22:633-644. https://doi.org/10.1097/FBP.0b013e32834afef9
  14. Long BB. The effects of gynostemma on sports ability of mice. Zhongguo Ying Yong Sheng Li Xue Za Zhi 2010;26:339-340.
  15. Grodzinskij AM, ed. Phytoergonomics. Kyiv: Naukova Dumka, 1989.
  16. Grinevich MA. Information search for perspective medicinal plants: an experience of studies on the traditional medicine of Eastern Asia with the aid of computer. Leningrad: Nauka, 1990.
  17. Vinogradov VM, Krivoruchko BI. Pharmacological defence of the brain from hypoxia. Psychopharmacol Biol Narcol 2001;1:27-37.
  18. Sidorova NV, Kiikova OI. Dibazol: a remedy for prophylaxis of acute respiratory infections among students of military colleges. Zh Mikrobiol Epidemiol Immunobiol 2000;(6):122-124.
  19. Udintsev SN, Shakhov VP, Borovskoi IG, Ibragimova SG. The effect of low concentrations of adaptogen solutions on the functional activity of murine bone marrow cells in vitro. Biofizika 1991;36:105-108.
  20. Novikov VS, Bortnovskii VN. Effect of dibazol on indices of nonspecific resistance in human subjects in a hermetically sealed enclosure. Kosm Biol Aviakosm Med 1985;19:68-71.
  21. Zarudii FS. Effect of obzidan, tropaphen, adrenaline and euphylline on histamine bronchospasm in guinea pigs. Farmakol Toksikol 1984;47:81-84.
  22. Rusin VI. Influence of muscle training, adaptation to cold and dibazol administration on the resistance of certain tissues. Fiziol Zh SSSR Im I M Sechenova 1967;53:431-437.
  23. Rusin VI. Resistance to cold and heat in animals receiving dibazol or subjected to muscular training and acclimatization. Fiziol Zh SSSR Im I M Sechenova 1963;49:359-365.
  24. Rusin VI. The effect of prolonged dibazol administration on the growth and resistance of white mice and their offspring. Fiziol Zh SSSR Im I M Sechenova 1963;49:632-638.
  25. Rusin VI. The effect of dibazol and adaptation to muscular work and cold on animals with the Ehrlich tumor. Vopr Onkol 1963;18:60-66.
  26. Rusin VI. On adaptation to cold and heat in muscular training and in dibazol administration. Patol Fiziol Eksp Ter 1962;6:63-65.
  27. Rusin VI. Role of the adaptation to low temperatures and dibazol in increased resistance of mice to adverse factors. Fiziol Zh SSSR Im I M Sechenova 1962;48:195-200.
  28. Voskanian NA, Dzhikidze EK, Pochkhura MA. Immunological status of monkeys during acclimatization and its correction with levamisole. Zh Mikrobiol Epidemiol Immunobiol 1986;(3):62-65.
  29. Alvarez-Pellitero P, Sitja-Bobadilla A, Bermudez R, Quiroga MI. Levamisole activates several innate immune factors in Scophthalmus maximus (L.) Teleostei. Int J Immunopathol Pharmacol 2006;19:727-738. https://doi.org/10.1177/039463200601900403
  30. Chen LY, Lin YL, Chiang BL. Levamisole enhances immune response by affecting the activation and maturation of human monocyte-derived dendritic cells. Clin Exp Immunol 2008;151:174-181.
  31. Fabrizi F, Dixit V, Messa P, Martin P. Meta-analysis: levamisole improves the immune response to hepatitis B vaccine in dialysis patients. Aliment Pharmacol Ther 2010;32:756-762. https://doi.org/10.1111/j.1365-2036.2010.04410.x
  32. Zenina TA, Gavrish IV, Melkumyan DS, Seredenina TS, Seredenin SB. Neuroprotective properties of afobazol in vitro. Bull Exp Biol Med 2005;140:194-196. https://doi.org/10.1007/s10517-005-0443-7
  33. Uyanaev AA, Fisenko VP. Studies of long-term noopept and afobazol treatment in rats with learned helplessness neurosis. Bull Exp Biol Med 2006;142:202-204. https://doi.org/10.1007/s10517-006-0327-5
  34. Litvintsev SV, Davydov AT, Uspenskii IP, Zagrebel'nyi IA, Balukova EV. Using of aphobazol in the treatment of adaptation disorder in the contract service men, dismissed from the armed forces. Voen Med Zh 2007;328:28-29.
  35. Bogdan NG, Kolotilinskaia NV, Nadorov SA, Iarkova MA, Badyshtov BA. Effect of afobazole on the psychophysiological state of healthy volunteers. Eksp Klin Farmakol 2011;74:8-12.
  36. Bobkov IG, Vinogradov VM, Katkov VP, Losev SS, Smirnov AV. Pharmacological correction of tirednass. Moscow: Meditsina, 1984.
  37. Chung HS, Lee YC, Rhee YK, Lee SY. Consumer acceptance of ginseng food products. J Food Sci 2011;76:S516-S522. https://doi.org/10.1111/j.1750-3841.2011.02399.x
  38. Yap KY, Chan SY, Weng Chan Y, Sing Lim C. Overview on the analytical tools for quality control of natural product-based supplements: a case study of ginseng. Assay Drug Dev Technol 2005;3:683-699. https://doi.org/10.1089/adt.2005.3.683
  39. Yun TK. Brief introduction of Panax ginseng C.A. Meyer. J Korean Med Sci 2001;16 Suppl:S3-S5. https://doi.org/10.3346/jkms.2001.16.S.S3
  40. Court WE. Ginseng: the history of an insignificant plant. Pharm Hist (Lond) 2000;30:38-44.
  41. Tachikawa E, Kudo K, Harada K, Kashimoto T, Miyate Y, Kakizaki A, Takahashi E. Effects of ginseng saponins on responses induced by various receptor stimuli. Eur J Pharmacol 1999;369:23-32. https://doi.org/10.1016/S0014-2999(99)00043-6
  42. Christensen LP. Ginsenosides chemistry, biosynthesis, analysis, and potential health effects. Adv Food Nutr Res 2009;55:1-99.
  43. Attele AS, Wu JA, Yuan CS. Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol 1999;58:1685-1693. https://doi.org/10.1016/S0006-2952(99)00212-9
  44. Choi KT. Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C A Meyer. Acta Pharmacol Sin 2008;29:1109-1118. https://doi.org/10.1111/j.1745-7254.2008.00869.x
  45. Liberti LE, Der Marderosian A. Evaluation of commercial ginseng products. J Pharm Sci 1978;67:1487-1489. https://doi.org/10.1002/jps.2600671050
  46. Yuan CS, Wang CZ, Wicks SM, Qi LW. Chemical and pharmacological studies of saponins with a focus on American ginseng. J Ginseng Res 2010;34:160-167. https://doi.org/10.5142/jgr.2010.34.3.160
  47. Kim DH. Chemical diversity of Panax ginseng, Panax quinquifolium, and Panax notoginseng. J Ginseng Res 2012;36:1-15. https://doi.org/10.5142/jgr.2012.36.1.1
  48. Zhu S, Zou K, Fushimi H, Cai S, Komatsu K. Comparative study on triterpene saponins of ginseng drugs. Planta Med 2004;70:666-677. https://doi.org/10.1055/s-2004-827192
  49. Li C, Cai J, Geng J, Li Y, Wang Z, Li R. Purification, characterization and anticancer activity of a polysaccharide from Panax ginseng. Int J Biol Macromol 2012; 51:968-973. https://doi.org/10.1016/j.ijbiomac.2012.06.031
  50. Wang R, Chen P, Jia F, Tang J, Ma F. Optimization of polysaccharides from Panax japonicus C.A. Meyer by RSM and its anti-oxidant activity. Int J Biol Macromol 2012;50:331-336. https://doi.org/10.1016/j.ijbiomac.2011.12.023
  51. Wang J, Flaisher-Grinberg S, Li S, Liu H, Sun L, Zhou Y, Einat H. Antidepressant-like effects of the active acidic polysaccharide portion of ginseng in mice. J Ethnopharmacol 2010;132:65-69. https://doi.org/10.1016/j.jep.2010.07.042
  52. Wang J, Li S, Fan Y, Chen Y, Liu D, Cheng H, Gao X, Zhou Y. Anti-fatigue activity of the water-soluble polysaccharides isolated from Panax ginseng C. A. Meyer. J Ethnopharmacol 2010;130:421-423. https://doi.org/10.1016/j.jep.2010.05.027
  53. Court WE. Ginseng, the genus Panax. Boca Raton: CRC Press, 2000.
  54. Soldati F, Sticher O. HPLC separation and quantitative determination of ginsenosides from Panax ginseng, Panax quinquefolium and from ginseng drug preparations. 2nd communication. Planta Med 1980;39:348-357. https://doi.org/10.1055/s-2008-1074929
  55. Grandhi A, Mujumdar AM, Patwardhan B. A comparative pharmacological investigation of Ashwagandha and ginseng. J Ethnopharmacol 1994;44:131-135. https://doi.org/10.1016/0378-8741(94)01119-2
  56. Singh A, Saxena E, Bhutani KK. Adrenocorticosterone alterations in male, albino mice treated with Trichopus zeylanicus, Withania somnifera and Panax ginseng preparations. Phytother Res 2000;14:122-125. https://doi.org/10.1002/(SICI)1099-1573(200003)14:2<122::AID-PTR529>3.0.CO;2-S
  57. Jung K, Kim IH, Han D. Effect of medicinal plant extracts on forced swimming capacity in mice. J Ethnopharmacol 2004;93:75-81. https://doi.org/10.1016/j.jep.2004.03.022
  58. Choi JY, Woo TS, Yoon SY, dela Pena IC, Choi YJ, Ahn HS, Lee YS, Yu GY, Cheong JH. Red ginseng supplementation more effectively alleviates psychological than physical fatigue. J Ginseng Res 2011;35:331-338. https://doi.org/10.5142/jgr.2011.35.3.331
  59. Nocerino E, Amato M, Izzo AA. The aphrodisiac and adaptogenic properties of ginseng. Fitoterapia 2000;71 Suppl 1:S1-S5. https://doi.org/10.1016/S0367-326X(00)00170-2
  60. Min YK, Chung SH, Lee JS, Kim SS, Shin HD, Lim BV, Shin MC, Jang MH, Kim EH, Kim CJ. Red ginseng inhibits exercise-induced increase in 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in dorsal raphe of rats. J Pharmacol Sci 2003;93:218-221. https://doi.org/10.1254/jphs.93.218
  61. Zhao W, Zhang X, Wang W, Zhang L. Experimental study for the anti-fatigue effect of ginseng general ginsenosides P.E. in vivo. Wei Sheng Yan Jiu 2009;38:184-187.
  62. Filaretov AA, Bogdanova TS, Podvigina TT, Bodganov AI. Role of pituitary-adrenocortical system in body adaptation abilities. Exp Clin Endocrinol 1988;92:129-136. https://doi.org/10.1055/s-0029-1210793
  63. Wang LC, Lee TF. Effect of ginseng saponins on exercise performance in non-trained rats. Planta Med 1998;64:130-133. https://doi.org/10.1055/s-2006-957389
  64. Wang LW, Liu XM, Lu GH, Gao NN, Xiao PG. Primary research of pharmacological effects of PEC on mice. Zhongguo Zhong Yao Za Zhi 2004;29:568-569, 593.
  65. Martinez B, Staba EJ. The physiological effects of Aralia, Panax and Eleutherococcus on exercised rats. Jpn J Pharmacol 1984;35:79-85. https://doi.org/10.1254/jjp.35.79
  66. Williams MH. Ergogenic and ergolytic substances. Med Sci Sports Exerc 1992;24(9 Suppl):S344-S348.
  67. Bucci LR. Selected herbals and human exercise performance. Am J Clin Nutr 2000;72(2 Suppl):624S-636S. https://doi.org/10.1093/ajcn/72.2.624S
  68. Ziemba AW, Chmura J, Kaciuba-Uscilko H, Nazar K, Wisnik P, Gawronski W. Ginseng treatment improves psychomotor performance at rest and during graded exercise in young athletes. Int J Sport Nutr 1999;9:371-377. https://doi.org/10.1123/ijsn.9.4.371
  69. Pieralisi G, Ripari P, Vecchiet L. Effects of a standardized ginseng extract combined with dimethylaminoethanol bitartrate, vitamins, minerals, and trace elements on physical performance during exercise. Clin Ther 1991;13:373-382.
  70. Kulaputana O, Thanakomsirichot S, Anomasiri W. Ginseng supplementation does not change lactate threshold and physical performances in physically active Thai men. J Med Assoc Thai 2007;90:1172-1179.
  71. Forgo I, Kayasseh L, Staub JJ. Effect of a standardized ginseng extract on general well-being, reaction time, lung function and gonadal hormones. Med Welt 1981;32:751-756.
  72. Forgo I. Effect of drugs on physical exertion and the hormonal system of athletes. 2. MMW Munch Med Wochenschr 1983;125:822-824.
  73. World Health Organization. Radix Ginseng. In: World Health Organization. WHO monographs on selected medicinal plants. Volume 1. Geneva: World Health Organization, 1999. p. 168-182.
  74. Von Ardenne M, Klemm W. Measurements of the increase in the difference between the arterial and venous Hb-O2 saturation obtained with daily administration of 200 mg standardized ginseng extract G115 for four weeks. Long-term increase of the O2 transport into the organs and tissues of the organism through biologically active substances. Panminerva Med 1987;29:143-150.
  75. Wolinsky I, Driskell JA, eds. Nutritional ergogenic aids. Boca Raton: CRC Press, 2004.
  76. Caso Marasco A, Vargas Ruiz R, Salas Villagomez A, Begona Infante C. Double-blind study of a multivitamin complex supplemented with ginseng extract. Drugs Exp Clin Res 1996;22:323-329.
  77. Lifton B, Otto RM, Wygard J. The effect of ginseng on acute maximal aerobic exercise. Med Sci Sports Exerc 1997;29(Suppl 5):S249.
  78. Engels HJ, Wirth JC. No ergogenic effects of ginseng (Panax ginseng C.A. Meyer) during graded maximal aerobic exercise. J Am Diet Assoc 1997;97:1110-1115. https://doi.org/10.1016/S0002-8223(97)00271-X
  79. Allen JD, McLung J, Nelson AG, Welsch M. Ginseng supplementation does not enhance healthy young adults' peak aerobic exercise performance. J Am Coll Nutr 1998;17:462-466. https://doi.org/10.1080/07315724.1998.10718795
  80. Kolokouri I, Engels HJ, Cieslak T, Wirth JC. Effect of chronic ginseng supplementation on short duration, supramaximal exercise test performance. Med Sci Sports Exerc 1999;31(Suppl 5):S117.
  81. Engels HJ, Kolokouri I, Cieslak TJ 2nd, Wirth JC. Effects of ginseng supplementation on supramaximal exercise performance and short-term recovery. J Strength Cond Res 2001;15:290-295.
  82. Cardinal BJ, Engels HJ. Ginseng does not enhance psychological well-being in healthy, young adults: results of a double-blind, placebo-controlled, randomized clinical trial. J Am Diet Assoc 2001;101:655-660. https://doi.org/10.1016/S0002-8223(01)00165-1
  83. Kang HY, Kim SH, Lee WJ, Byrne HK. Effects of ginseng ingestion on growth hormone, testosterone, cortisol, and insulin-like growth factor 1 responses to acute resistance exercise. J Strength Cond Res 2002;16:179-183.
  84. Kim SH, Park KS, Chang MJ, Sung JH. Effects of Panax ginseng extract on exercise-induced oxidative stress. J Sports Med Phys Fitness 2005;45:178-182.
  85. Engels HJ, Fahlman MM, Wirth JC. Effects of ginseng on secretory IgA, performance, and recovery from interval exercise. Med Sci Sports Exerc 2003;35:690-696. https://doi.org/10.1249/01.MSS.0000058363.23986.D2
  86. Ping FW, Keong CC, Bandyopadhyay A. Effects of acute supplementation of Panax ginseng on endurance running in a hot & humid environment. Indian J Med Res 2011;133:96-102.
  87. Jung HL, Kwak HE, Kim SS, Kim YC, Lee CD, Byurn HK, Kang HY. Effects of Panax ginseng supplementation on muscle damage and inflammation after uphill treadmill running in humans. Am J Chin Med 2011;39:441-450. https://doi.org/10.1142/S0192415X11008944
  88. Morris AC, Jacobs I, McLellan TM, Klugerman A, Wang LC, Zamecnik J. No ergogenic effect of ginseng ingestion. Int J Sport Nutr 1996;6:263-271. https://doi.org/10.1123/ijsn.6.3.263
  89. Biondo PD, Robbins SJ, Walsh JD, McCargar LJ, Harber VJ, Field CJ. A randomized controlled crossover trial of the effect of ginseng consumption on the immune response to moderate exercise in healthy sedentary men. Appl Physiol Nutr Metab 2008;33:966-975. https://doi.org/10.1139/H08-080
  90. Liang MT, Podolka TD, Chuang WJ. Panax notoginseng supplementation enhances physical performance during endurance exercise. J Strength Cond Res 2005;19:108-114. https://doi.org/10.1519/00124278-200502000-00019
  91. Saito H, Yoshida Y, Takagi K. Effect of Panax ginseng root on exhaustive exercise in mice. Jpn J Pharmacol 1974;24:119-127. https://doi.org/10.1254/jjp.24.119
  92. Banerjee U, Izquierdo JA. Antistress and antifatigue properties of Panax ginseng: comparison with piracetam. Acta Physiol Lat Am 1982;32:277-285.
  93. Dai W, Zhang F, Jia Z, Wei C, Gao P, Lu X, Wu Y, Xu G. Evaluation of the effect of the traditional Chinese medicine tongxinluo or ginseng on excess fatigue rats studied by metabonomics approach based on liquid chromatography-mass spectrometry. Se Pu 2011;29:1049-1054.
  94. Bentler SE, Hartz AJ, Kuhn EM. Prospective observational study of treatments for unexplained chronic fatigue. J Clin Psychiatry 2005;66:625-632. https://doi.org/10.4088/JCP.v66n0513
  95. Elam JL, Carpenter JS, Shu XO, Boyapati S, Friedmann-Gilchrist J. Methodological issues in the investigation of ginseng as an intervention for fatigue. Clin Nurse Spec 2006;20:183-189. https://doi.org/10.1097/00002800-200607000-00007
  96. Barton DL, Soori GS, Bauer BA, Sloan JA, Johnson PA, Figueras C, Duane S, Mattar B, Liu H, Atherton PJ et al. Pilot study of Panax quinquefolius (American ginseng) to improve cancer-related fatigue: a randomized, double-blind, dose-finding evaluation: NCCTG trial N03CA. Support Care Cancer 2010;18:179-187. https://doi.org/10.1007/s00520-009-0642-2
  97. Bahrke MS, Morgan WP. Evaluation of the ergogenic properties of ginseng. Sports Med 1994;18:229-248. https://doi.org/10.2165/00007256-199418040-00003
  98. Bahrke MS, Morgan WR. Evaluation of the ergogenic properties of ginseng: an update. Sports Med 2000;29: 113-133. https://doi.org/10.2165/00007256-200029020-00004
  99. Bahrke MS. Ginseng: a root just like a carrot? J R Soc Med 1995;88:304.
  100. Bahrke MS, Morgan WP, Stegner A. Is ginseng an ergogenic aid? Int J Sport Nutr Exerc Metab 2009;19:298-322. https://doi.org/10.1123/ijsnem.19.3.298
  101. Chen CK, Muhamad AS, Ooi FK. Herbs in exercise and sports. J Physiol Anthropol 2012;31:4. https://doi.org/10.1186/1880-6805-31-4
  102. Ferrando A, Vila L, Voces JA, Cabral AC, Alvarez AI, Prieto JG. Effects of ginseng extract on various haematological parameters during aerobic exercise in the rat. Planta Med 1999;65:288-290. https://doi.org/10.1055/s-2006-960783
  103. Ferrando A, Vila L, Voces JA, Cabral AC, Alvarez AI, Prieto JG. Effects of a standardized Panax ginseng extract on the skeletal muscle of the rat: a comparative study in animals at rest and under exercise. Planta Med 1999;65:239-244. https://doi.org/10.1055/s-1999-14081
  104. Avakian EV Jr, Evonuk E. Effect of Panax ginseng extract on tissue glycogen and adrenal cholesterol depletion during prolonged exercise. Planta Med 1979;36:43-48. https://doi.org/10.1055/s-0028-1097238
  105. Avakian EV, Sugimoto RB, Taguchi S, Horvath SM. Effect of Panax ginseng extract on energy metabolism during exercise in rats. Planta Med 1984;50:151-154. https://doi.org/10.1055/s-2007-969657
  106. Yang Y, Wu T, He K, Fu ZG. Effect of aerobic exercise and ginsenosides on lipid metabolism in diet-induced hyperlipidemia mice. Zhongguo Yao Li Xue Bao 1999;20:563-565.
  107. Voces J, Cabral de Oliveira AC, Prieto JG, Vila L, Perez AC, Duarte ID, Alvarez AI. Ginseng administration protects skeletal muscle from oxidative stress induced by acute exercise in rats. Braz J Med Biol Res 2004;37:1863-1871. https://doi.org/10.1590/S0100-879X2004001200012
  108. Cabral de Oliveira AC, Perez AC, Prieto JG, Duarte ID, Alvarez AI. Protection of Panax ginseng in injured muscles after eccentric exercise. J Ethnopharmacol 2005;97: 211-214. https://doi.org/10.1016/j.jep.2004.10.029
  109. Hwang HJ, Kwak YS, Yoon GA, Kang MH, Park JH, Lee BK, Kim SJ, Um SY, Kim YM. Combined effects of swim training and ginseng supplementation on exercise performance time, ROS, lymphocyte proliferation, and DNA damage following exhaustive exercise stress. Int J Vitam Nutr Res 2007;77:289-296. https://doi.org/10.1024/0300-9831.77.4.289
  110. Yu SH, Huang HY, Korivi M, Hsu MF, Huang CY, Hou CW, Chen CY, Kao CL, Lee RP, Lee SD et al. Oral Rg1 supplementation strengthens antioxidant defense system against exercise-induced oxidative stress in rat skeletal muscles. J Int Soc Sports Nutr 2012;9:23. https://doi.org/10.1186/1550-2783-9-23
  111. Korivi M, Hou CW, Huang CY, Lee SD, Hsu MF, Yu SH, Chen CY, Liu YY, Kuo CH. Ginsenoside-Rg1 protects the liver against exhaustive exercise-induced oxidative stress in rats. Evid Based Complement Alternat Med 2012;2012:932165.
  112. Zhang JT, Qu ZW, Liu Y, Deng HL. Preliminary study on antiamnestic mechanism of ginsenoside Rg1 and Rb1. Chin Med J (Engl) 1990;103:932-938.
  113. Benishin CG, Lee R, Wang LC, Liu HJ. Effects of ginsenoside Rb1 on central cholinergic metabolism. Pharmacology 1991;42:223-229. https://doi.org/10.1159/000138801
  114. Ma TC, Yu QH. Effect of 20(S)-ginsenoside-Rg2 and cyproheptadine on two-way active avoidance learning and memory in rats. Arzneimittelforschung 1993;43:1049-1052.
  115. Li Z, Guo YY, Wu CF, Li X, Wang JH. Protective effects of pseudoginsenoside-F11 on scopolamine-induced memory impairment in mice and rats. J Pharm Pharmacol 1999;51:435-440. https://doi.org/10.1211/0022357991772484
  116. Yamazaki M, Hirakura K, Miyaichi Y, Imakura K, Kita M, Chiba K, Mohri T. Effect of polyacetylenes on the neurite outgrowth of neuronal culture cells and scopolamine-induced memory impairment in mice. Biol Pharm Bull 2001;24:1434-1436. https://doi.org/10.1248/bpb.24.1434
  117. Bao HY, Zhang J, Yeo SJ, Myung CS, Kim HM, Kim JM, Park JH, Cho J, Kang JS. Memory enhancing and neuroprotective effects of selected ginsenosides. Arch Pharm Res 2005;28:335-342. https://doi.org/10.1007/BF02977802
  118. Yang JH, Han SJ, Ryu JH, Jang IS, Kim DH. Ginsenoside Rh2 ameliorates scopolamine-induced learning deficit in mice. Biol Pharm Bull 2009;32:1710-1715. https://doi.org/10.1248/bpb.32.1710
  119. Wang Q, Sun LH, Jia W, Liu XM, Dang HX, Mai WL, Wang N, Steinmetz A, Wang YQ, Xu CJ. Comparison of ginsenosides Rg1 and Rb1 for their effects on improving scopolamine-induced learning and memory impairment in mice. Phytother Res 2010;24:1748-1754. https://doi.org/10.1002/ptr.3130
  120. Lasarova MB, Mosharrof AH, Petkov VD, Markovska VL, Petkov VV. Effect of piracetam and of standardized ginseng extract on the electroconvulsive shock-induced memory disturbances in “step-down” passive avoidance. Acta Physiol Pharmacol Bulg 1987;13:11-17.
  121. Petkov VD, Mosharrof AH. Effects of standardized ginseng extract on learning, memory and physical capabilities. Am J Chin Med 1987;15:19-29. https://doi.org/10.1142/S0192415X87000047
  122. Zhang L, Zhang JT. Memory facilitation induced by Panax ginseng and pseudoginseng in mice. Zhong Xi Yi Jie He Za Zhi 1987;7:610-612.
  123. Jaenicke B, Kim EJ, Ahn JW, Lee HS. Effect of Panax ginseng extract on passive avoidance retention in old rats. Arch Pharm Res 1991;14:25-29. https://doi.org/10.1007/BF02857809
  124. Petkov VD, Cao Y, Todorov I, Lazarova M, Getova D, Stancheva S, Alova L. Behavioral effects of stem-leaves extract from Panax ginseng C.A. Meyer. Acta Physiol Pharmacol Bulg 1992;18:41-48.
  125. Petkov VD, Kehayov R, Belcheva S, Konstantinova E, Petkov VV, Getova D, Markovska V. Memory effects of standardized extracts of Panax ginseng (G115), Ginkgo biloba (GK 501) and their combination Gincosan (PHL-00701). Planta Med 1993;59:106-114. https://doi.org/10.1055/s-2006-959623
  126. Nitta H, Matsumoto K, Shimizu M, Ni XH, Watanabe H. Panax ginseng extract improves the performance of aged Fischer 344 rats in radial maze task but not in operant brightness discrimination task. Biol Pharm Bull 1995;18:1286-1288. https://doi.org/10.1248/bpb.18.1286
  127. Nitta H, Matsumoto K, Shimizu M, Ni XH, Watanabe H. Panax ginseng extract improves the scopolamine-induced disruption of 8-arm radial maze performance in rats. Biol Pharm Bull 1995;18:1439-1442. https://doi.org/10.1248/bpb.18.1439
  128. Wang A, Cao Y, Wang Y, Zhao R, Liu C. Effects of Chinese ginseng root and stem-leaf saponins on learning, memory and biogenic monoamines of brain in rats. Zhongguo Zhong Yao Za Zhi 1995;20:493-495.
  129. Zhao R, McDaniel WF. Ginseng improves strategic learning by normal and brain-damaged rats. Neuroreport 1998;9:1619-1624. https://doi.org/10.1097/00001756-199805110-00066
  130. Jin SH, Park JK, Nam KY, Park SN, Jung NP. Korean red ginseng saponins with low ratios of protopanaxadiol and protopanaxatriol saponin improve scopolamine-induced learning disability and spatial working memory in mice. J Ethnopharmacol 1999;66:123-129. https://doi.org/10.1016/S0378-8741(98)00190-1
  131. Hsieh MT, Peng WH, Wu CR, Wang WH. The ameliorating effects of the cognitive-enhancing Chinese herbs on scopolamine-induced amnesia in rats. Phytother Res 2000;14:375-377. https://doi.org/10.1002/1099-1573(200008)14:5<375::AID-PTR593>3.0.CO;2-5
  132. Petkov VD, Belcheva S, Petkov VV. Behavioral effects of Ginkgo biloba L., Panax ginseng C.A. Mey. and Gincosan. Am J Chin Med 2003;31:841-855. https://doi.org/10.1142/S0192415X03001533
  133. Kurimoto H, Nishijo H, Uwano T, Yamaguchi H, Zhong YM, Kawanishi K, Ono T. Effects of nonsaponin fraction of red ginseng on learning deficits in aged rats. Physiol Behav 2004;82:345-355. https://doi.org/10.1016/j.physbeh.2004.04.001
  134. Lee B, Park J, Kwon S, Park MW, Oh SM, Yeom MJ, Shim I, Lee HJ, Hahm DH. Effect of wild ginseng on scopolamine-induced acetylcholine depletion in the rat hippocampus. J Pharm Pharmacol 2010;62:263-271. https://doi.org/10.1211/jpp.62.02.0015
  135. Sanghavi CR, Barhate SA, Mahajan MS, Mohan M, Kasture SB. Korean ginseng extract attenuates reserpine-induced orofacial dyskinesia and improves cognitive dysfunction in rats. Nat Prod Res 2011;25:704-715. https://doi.org/10.1080/14786410802583031
  136. Sloley BD, Pang PK, Huang BH, Ba F, Li FL, Benishin CG, Greenshaw AJ, Shan JJ. American ginseng extract reduces scopolamine-induced amnesia in a spatial learning task. J Psychiatry Neurosci 1999;24:442-452.
  137. Zhong YM, Nishijo H, Uwano T, Tamura R, Kawanishi K, Ono T. Red ginseng ameliorated place navigation deficits in young rats with hippocampal lesions and aged rats. Physiol Behav 2000;69:511-525. https://doi.org/10.1016/S0031-9384(00)00206-7
  138. Wang LC, Wang B, Ng SY, Lee TF. Effects of ginseng saponins on beta-amyloid-induced amnesia in rats. J Ethnopharmacol 2006;103:103-108. https://doi.org/10.1016/j.jep.2005.07.010
  139. Chatterjee M, Singh S, Kumari R, Verma AK, Palit G. Evaluation of the antipsychotic potential of Panax quinquefolium in ketamine induced experimental psychosis model in mice. Neurochem Res 2012;37:759-770. https://doi.org/10.1007/s11064-011-0670-4
  140. Chuang CM, Hsieh CL, Lin HY, Lin JG. Panax notoginseng Burk attenuates impairment of learning and memory functions and increases ED1, BDNF and beta-secretase immunoreactive cells in chronic stage ischemia-reperfusion injured rats. Am J Chin Med 2008;36:685-693. https://doi.org/10.1142/S0192415X08006156
  141. Zhong ZG, Lv L, Chai LM, Wu DP, Zhang WY, Huang JL, Gang YW, Li F, Zu B. Effect of Panax notoginseng saponins on APP gene transcription in the brain tissue of SAMP8. Zhong Yao Cai 2011;34:77-80.
  142. Saito H, Tsuchiya M, Naka S, Takagi K. Effects of Panax ginseng root on conditioned avoidance response in rats. Jpn J Pharmacol 1977;27:509-516. https://doi.org/10.1254/jjp.27.509
  143. Takagi K, Saito H, Tsuchiya M. Pharmacological studies of Panax ginseng root: pharmacological properties of a crude saponin fraction. Jpn J Pharmacol 1972;22:339-346. https://doi.org/10.1254/jjp.22.339
  144. Takagi K, Saito H, Nabata H. Pharmacological studies of Panax ginseng root: estimation of pharmacological actions of Panax ginseng root. Jpn J Pharmacol 1972;22:245-249. https://doi.org/10.1254/jjp.22.245
  145. Wang XY, Chen J, Zhang JT. Effect of ginsenoside Rg1 on learning and memory impairment induced by beta-amyloid peptide(25-35) and its mechanism of action. Yao Xue Xue Bao 2001;36:1-4.
  146. Wee JJ, Park KM, Chung AS. Biological activities of ginseng and its application to human health. In: Benzie IF, Wachtel-Galor S, eds. Herbal medicine: biomolecular and clinical aspects. 2nd ed. Boca Raton: CRC Press, 2011. p. 157-174.
  147. Liu L, Hoang-Gia T, Wu H, Lee MR, Gu L, Wang C, Yun BS, Wang Q, Ye S, Sung CK. Ginsenoside Rb1 improves spatial learning and memory by regulation of cell genesis in the hippocampal subregions of rats. Brain Res 2011;1382:147-154. https://doi.org/10.1016/j.brainres.2011.01.051
  148. Kochmareva LL. The effect of Schizandra chinensis and ginseng on processes of concentration. In: Lazarev NV, ed. Materials for the study of ginseng and Schizandra. Leningrad: V. L. Komarov's Far East Branch of USSR Academy of Science, 1958. p. 12-17.
  149. Medvedev MA. Effect of ginseng and eleutherococcus on working parameters of radio-telegraph operators. In: Brekhman II, Belikov IF, Kurentsova GE, eds. Materials of studies of ginseng and other medicinal plants of Far East. Vladivostok: Primorye Publishing Press, 1963. p. 237-239.
  150. Popov IM, Goldwag WJ. A review of the properties and clinical effects of ginseng. Am J Chin Med (Gard City N Y) 1973;1:263-270. https://doi.org/10.1142/S0192415X73000280
  151. Hallstrom C, Fulder S, Carruthers M. Effects of ginseng on the performance of nurses on night duty. Am J Chin Med 1978;6:277-282. https://doi.org/10.1142/S014729177800037X
  152. Kennedy DO, Scholey AB, Wesnes KA. Dose dependent changes in cognitive performance and mood following acute administration of ginseng to healthy young volunteers. Nutr Neurosci 2001;4:295-310. https://doi.org/10.1080/1028415X.2001.11747370
  153. Kennedy DO, Jackson PA, Elliott JM, Scholey AB, Robertson BC, Greer J, Tiplady B, Buchanan T, Haskell CF. Cognitive and mood effects of 8 weeks' supplementation with 400 mg or 1000 mg of the omega-3 essential fatty acid docosahexaenoic acid (DHA) in healthy children aged 10-12 years. Nutr Neurosci 2009;12:48-56. https://doi.org/10.1179/147683009X388887
  154. Reay JL, Scholey AB, Kennedy DO. Panax ginseng (G115) improves aspects of working memory performance and subjective ratings of calmness in healthy young adults. Hum Psychopharmacol 2010;25:462-471. https://doi.org/10.1002/hup.1138
  155. Reay JL, Scholey AB, Milne A, Fenwick J, Kennedy DO. Panax ginseng has no effect on indices of glucose regulation following acute or chronic ingestion in healthy volunteers. Br J Nutr 2009;101:1673-1678. https://doi.org/10.1017/S0007114508123418
  156. Kennedy DO, Scholey AB. Ginseng: potential for the enhancement of cognitive performance and mood. Pharmacol Biochem Behav 2003;75:687-700. https://doi.org/10.1016/S0091-3057(03)00126-6
  157. Kennedy DO, Scholey AB, Wesnes KA. Differential, dose dependent changes in cognitive performance following acute administration of a Ginkgo biloba/Panax ginseng combination to healthy young volunteers. Nutr Neurosci 2001;4:399-412. https://doi.org/10.1080/1028415X.2001.11747376
  158. Kennedy DO, Scholey AB, Wesnes KA. Modulation of cognition and mood following administration of single doses of Ginkgo biloba, ginseng, and a ginkgo/ginseng combination to healthy young adults. Physiol Behav 2002;75:739-751. https://doi.org/10.1016/S0031-9384(02)00665-0
  159. Reay JL, Kennedy DO, Scholey AB. Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity. J Psychopharmacol 2005;19:357-365. https://doi.org/10.1177/0269881105053286
  160. Reay JL, Kennedy DO, Scholey AB. Effects of Panax ginseng, consumed with and without glucose, on blood glucose levels and cognitive performance during sustained 'mentally demanding' tasks. J Psychopharmacol 2006;20:771-781. https://doi.org/10.1177/0269881106061516
  161. Simon W, Kirchdorfer AM, Dahse G. Efficiency control of a ginseng containing geriatric drug by means of the Kraepelin method. Med Monatsschr 1977;31:39-41.
  162. Hobbs C. The ginseng: a user's guide. Santa Cruz: Botanica Press, 1996.
  163. D'Angelo L, Grimaldi R, Caravaggi M, Marcoli M, Perucca E, Lecchini S, Frigo GM, Crema A. A double-blind, placebo-controlled clinical study on the effect of a standardized ginseng extract on psychomotor performance in healthy volunteers. J Ethnopharmacol 1986;16:15-22. https://doi.org/10.1016/0378-8741(86)90063-2
  164. Zhao XZ. Antisenility effect of ginseng-rhizome saponin. Zhong Xi Yi Jie He Za Zhi 1990;10:586-589.
  165. Wiklund I, Karlberg J, Lund B. A double-blind comparison of the effect on quality of life of a combination of vital substances including standardized ginseng G115 and placebo. Curr Ther Res 1994;55:32-42. https://doi.org/10.1016/S0011-393X(05)80075-X
  166. Sorensen H, Sonne J. A doubled-masked study of the effects of ginseng on cognitive functions. Curr Ther Res 1996;57:959-968. https://doi.org/10.1016/S0011-393X(96)80114-7
  167. Lee ST, Chu K, Sim JY, Heo JH, Kim M. Panax ginseng enhances cognitive performance in Alzheimer disease. Alzheimer Dis Assoc Disord 2008;22:222-226. https://doi.org/10.1097/WAD.0b013e31816c92e6
  168. Heo JH, Lee ST, Oh MJ, Park HJ, Shim JY, Chu K, Kim M. Improvement of cognitive deficit in Alzheimer's disease patients by long term treatment with Korean red ginseng. J Ginseng Res 2011;35:457-461. https://doi.org/10.5142/jgr.2011.35.4.457
  169. Yeo HB, Yoon HK, Lee HJ, Kang SG, Jung KY, Kim L. Effects of Korean red ginseng on cognitive and motor function: a double-blind, randomized, placebo-controlled trial. J Ginseng Res 2012;36:190-197. https://doi.org/10.5142/jgr.2012.36.2.190
  170. Scholey A, Ossoukhova A, Owen L, Ibarra A, Pipingas A, He K, Roller M, Stough C. Effects of American ginseng (Panax quinquefolius) on neurocognitive function: an acute, randomised, double-blind, placebo-controlled, crossover study. Psychopharmacology (Berl) 2010;212:345-356. https://doi.org/10.1007/s00213-010-1964-y
  171. Chepurnov SA, Suleimanova EM, Guliaev MV, Abbasova KR, Pirogov IuA, Chepurnova NE. Neuroprotection in epilepsy. Usp Fiziol Nauk 2012;43:55-71.
  172. Perry E, Howes MJ. Medicinal plants and dementia therapy: herbal hopes for brain aging? CNS Neurosci Ther 2011;17:683-698. https://doi.org/10.1111/j.1755-5949.2010.00202.x
  173. Jesky R, Hailong C. Are herbal compounds the next frontier for alleviating learning and memory impairments? An integrative look at memory, dementia and the promising therapeutics of traditional chinese medicines. Phytother Res 2011;25:1105-1118. https://doi.org/10.1002/ptr.3388
  174. Geng J, Dong J, Ni H, Lee MS, Wu T, Jiang K, Wang G, Zhou AL, Malouf R. Ginseng for cognition. Cochrane Database Syst Rev 2010;(12):CD007769.
  175. Radad K, Moldzio R, Rausch WD. Ginsenosides and their CNS targets. CNS Neurosci Ther 2011;17:761-768. https://doi.org/10.1111/j.1755-5949.2010.00208.x
  176. Chu SF, Zhang JT. New achievements in ginseng research and its future prospects. Chin J Integr Med 2009;15:403-408. https://doi.org/10.1007/s11655-009-0403-6
  177. Liu Y, Li X, Yuan HF. Progress of research on effects of ginsenoside Rg1 in promoting capability of learning and memory. Zhongguo Zhong Xi Yi Jie He Za Zhi 2006;26:956-960.
  178. Zhang JT. Nootropic mechanisms of ginsenoside Rg1: influence on neuronal plasticity and neurogenesis. Yao Xue Xue Bao 2005;40:385-388.
  179. Cheng Y, Shen LH, Zhang JT. Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action. Acta Pharmacol Sin 2005;26:143-149. https://doi.org/10.1111/j.1745-7254.2005.00034.x
  180. Nishijo H, Uwano T, Zhong YM, Ono T. Proof of the mysterious efficacy of ginseng: basic and clinical trials: effects of red ginseng on learning and memory deficits in an animal model of amnesia. J Pharmacol Sci 2004;95:145-152. https://doi.org/10.1254/jphs.FMJ04001X3
  181. Lee MR, Yun BS, In OH, Sung CK. Comparative study of Korean white, red, and black ginseng extract on cholinesterase inhibitory activity and cholinergic function. J Ginseng Res 2011;35:421-428. https://doi.org/10.5142/jgr.2011.35.4.421
  182. Salim KN, McEwen BS, Chao HM. Ginsenoside Rb1 regulates ChAT, NGF and trkA mRNA expression in the rat brain. Brain Res Mol Brain Res 1997;47:177-182. https://doi.org/10.1016/S0169-328X(97)00042-9
  183. Chang Y, Huang WJ, Tien LT, Wang SJ. Ginsenosides Rg1 and Rb1 enhance glutamate release through activation of protein kinase A in rat cerebrocortical nerve terminals (synaptosomes). Eur J Pharmacol 2008;578:28-36. https://doi.org/10.1016/j.ejphar.2007.09.023
  184. Chang Y, Wang SJ. Ginsenoside Rg1 and Rb1 enhance glutamate exocytosis from rat cortical nerve terminals by affecting vesicle mobilization through the activation of protein kinase C. Eur J Pharmacol 2008;590:74-79. https://doi.org/10.1016/j.ejphar.2008.05.032

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