The Korean Journal of Pain

The Korean Pain Society (대한통증학회)
권호 표지
DOI QR코드

DOI QR Code

Effects of Palonosetron, a 5-HT3 Receptor Antagonist, on Mechanical Allodynia in a Rat Model of Postoperative Pain

  • Jung, Ki Tae (Department of Anesthesiology and Pain Medicine, School of Medicine, Chosun University) ;
  • Yoon, Myung Ha (Medical School, Chonnam National University) ;
  • Lee, Hyun Young (Department of Anesthesiology and Pain Medicine, School of Medicine, Chosun University) ;
  • Yu, Bo Yeon (Department of Anesthesiology and Pain Medicine, School of Medicine, Chosun University) ;
  • Kim, Dong Kyu (Department of Anesthesiology and Pain Medicine, School of Medicine, Chosun University) ;
  • Lim, Kyung Joon (Department of Anesthesiology and Pain Medicine, School of Medicine, Chosun University)
  • Received : 2012.12.06
  • Accepted : 2013.01.02
  • Published : 2013.04.01
Download PDF
⟨ Previous Next ⟩

Abstract

Background: 5-hydroxytryptamine 3 (5-HT3) receptors have been known to be associated with the modulation of nociceptive transmission. However, it is uncertain whether 5-HT3 plays a role in the antinociceptive or pronociceptive pathway for incisional pain. In this study, we evaluated the effects of palonosetron, a 5-HT3 receptor antagonist, on incisional pain in rats when administered intrathecally or intraplantarly. Methods: An intrathecal catheter was implanted through the cisterna magna and placed in the intrathecal space of rats. An incision in the plantaris muscle of the right hind paw was done under anesthesia with sevoflurane. Withdrawal thresholds were evaluated with the von Frey filament after 2 hours. Palonosetron (0.5 and 0.1 ${\mu}g$ intrathecally; 0.5 ${\mu}g$ intraplantarly) was administered and the thresholds were observed for 4 hours. Results: Mechanical hypersensitivity developed after the incision. Intrathecal palonosetron (0.5 ${\mu}g$ and 0.1 ${\mu}g$) did not alter the paw withdrawal threshold. Intraplantar palonosetron (0.5 ${\mu}g$) also did not change the paw withdrawal threshold. Conclusions: Intrathecal and intraplantar palonosetron (0.5 ${\mu}g$) had no effect on modulating the mechanical hypersensitivity in the incisional pain model of rats.

Keywords

References

  1. Faerber L, Drechsler S, Ladenburger S, Gschaidmeier H, Fischer W. The neuronal 5-HT3 receptor network after 20 years of research--evolving concepts in management of pain and inflammation. Eur J Pharmacol 2007; 560: 1-8. https://doi.org/10.1016/j.ejphar.2007.01.028
  2. Jeong CY, Bae HB, Park HC, Choi JI, Yoon MH. Evaluation of the role of 5-hydroxytryptamine receptor subtypes in the regulation of nociceptive transmission in the rat spinal cord. Korean J Anesthesiol 2004; 47: 856-861. https://doi.org/10.4097/kjae.2004.47.6.856
  3. Ali Z, Wu G, Kozlov A, Barasi S. The role of 5HT3 in nociceptive processing in the rat spinal cord: results from behavioural and electrophysiological studies. Neurosci Lett 1996; 208: 203-207. https://doi.org/10.1016/0304-3940(95)12600-7
  4. McCleane GJ, Suzuki R, Dickenson AH. Does a single intravenous injection of the 5HT3 receptor antagonist ondansetron have an analgesic effect in neuropathic pain? A double-blinded, placebo-controlled cross-over study. Anesth Analg 2003; 97: 1474-1478.
  5. Yaksh TL, Rudy TA. Chronic catheterization of the spinal subarachnoid space. Physiol Behav 1976; 17: 1031-1036. https://doi.org/10.1016/0031-9384(76)90029-9
  6. Brennan TJ, Vandermeulen EP, Gebhart GF. Characterization of a rat model of incisional pain. Pain 1996; 64: 493-501. https://doi.org/10.1016/0304-3959(95)01441-1
  7. Shin DJ, Yoon MH, Lee HG, Kim WM, Park BY, Kim YO, et al. The effect of treatment with intrathecal ginsenosides in a rat model of postoperative pain. Korean J Pain 2007; 20: 100-105. https://doi.org/10.3344/kjp.2007.20.2.100
  8. Wong EH, Clark R, Leung E, Loury D, Bonhaus DW, Jakeman L, et al. The interaction of RS 25259-197, a potent and selective antagonist, with 5-HT3 receptors, in vitro. Br J Pharmacol 1995; 114: 851-859. https://doi.org/10.1111/j.1476-5381.1995.tb13282.x
  9. Kovac AL, Eberhart L, Kotarski J, Clerici G, Apfel C; Palonosetron 04-07 Study Group. A randomized, doubleblind study to evaluate the efficacy and safety of three different doses of palonosetron versus placebo in preventing postoperative nausea and vomiting over a 72-hour period. Anesth Analg 2008; 107: 439-444. https://doi.org/10.1213/ane.0b013e31817abcd3
  10. Alhaider AA, Lei SZ, Wilcox GL. Spinal 5-HT3 receptormediated antinociception: possible release of GABA. J Neurosci 1991; 11: 1881-1888.
  11. Suzuki R, Rygh LJ, Dickenson AH. Bad news from the brain: descending 5-HT pathways that control spinal pain processing. Trends Pharmacol Sci 2004; 25: 613-617. https://doi.org/10.1016/j.tips.2004.10.002
  12. Suzuki R, Morcuende S, Webber M, Hunt SP, Dickenson AH. Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways. Nat Neurosci 2002; 5: 1319-1326. https://doi.org/10.1038/nn966
  13. Rahman W, Suzuki R, Hunt SP, Dickenson AH. Selective ablation of dorsal horn NK1 expressing cells reveals a modulation of spinal alpha2-adrenergic inhibition of dorsal horn neurones. Neuropharmacology 2008; 54: 1208-1214. https://doi.org/10.1016/j.neuropharm.2008.03.014
  14. Oatway MA, Chen Y, Weaver LC. The 5-HT3 receptor facilitates at-level mechanical allodynia following spinal cord injury. Pain 2004; 110: 259-268. https://doi.org/10.1016/j.pain.2004.03.040
  15. Vandermeulen EP, Brennan TJ. Alterations in ascending dorsal horn neurons by a surgical incision in the rat foot. Anesthesiology 2000; 93: 1294-1302. https://doi.org/10.1097/00000542-200011000-00024
  16. Zahn PK, Pogatzki EM, Brennan TJ. Mechanisms for pain caused by incisions. Reg Anesth Pain Med 2002; 27: 514-516. https://doi.org/10.1097/00115550-200209000-00014
  17. Pogatzki EM, Urban MO, Brennan TJ, Gebhart GF. Role of the rostral medial medulla in the development of primary and secondary hyperalgesia after incision in the rat. Anesthesiology 2002; 96: 1153-1160. https://doi.org/10.1097/00000542-200205000-00019
  18. Zeitz KP, Guy N, Malmberg AB, Dirajlal S, Martin WJ, Sun L, et al. The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors. J Neurosci 2002; 22: 1010-1019.
  19. Rahman W, Suzuki R, Webber M, Hunt SP, Dickenson AH. Depletion of endogenous spinal 5-HT attenuates the behavioural hypersensitivity to mechanical and cooling stimuli induced by spinal nerve ligation. Pain 2006; 123: 264-274. https://doi.org/10.1016/j.pain.2006.02.033
  20. Kress M, Reeh PW, Vyklicky L. An interaction of inflammatory mediators and protons in small diameter dorsal root ganglion neurons of the rat. Neurosci Lett 1997; 224: 37-40. https://doi.org/10.1016/S0304-3940(97)13450-4
  21. Sommer C. Is serotonin hyperalgesic or analgesic? Curr Pain Headache Rep 2006; 10: 101-106. https://doi.org/10.1007/s11916-006-0020-4
  22. Eschalier A, Kayser V, Guilbaud G. Influence of a specific 5-HT3 antagonist on carrageenan-induced hyperalgesia in rats. Pain 1989; 36: 249-255. https://doi.org/10.1016/0304-3959(89)90030-4
  23. Park SK, Cho EJ. A randomized, double-blind trial of palonosetron compared with ondansetron in preventing postoperative nausea and vomiting after gynaecological laparoscopic surgery. J Int Med Res 2011; 39: 399-407. https://doi.org/10.1177/147323001103900207

Cited by

  1. Effects of pretreatment with intravenous palonosetron for propofol-remifentanil-based anesthesia in breast and thyroid cancer surgery: a double-blind, randomized, controlled study vol.67, pp.1, 2014, https://doi.org/10.4097/kjae.2014.67.1.13
  2. Blockade of 5-HT3 receptors with granisetron does not affect trigeminothalamic nociceptive transmission in rats: Implication for migraine vol.45, pp.1, 2017, https://doi.org/10.1111/1440-1681.12849
  3. Comparison of the Prophylactic Antiemetic Efficacy of Aprepitant Plus Palonosetron Versus Aprepitant Plus Ramosetron in Patients at High Risk for Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy vol.26, pp.5, 2016, https://doi.org/10.1097/SLE.0000000000000316
  4. Pain-related mediators underlie incision-induced mechanical nociception in the dorsal root ganglia vol.8, pp.35, 2013, https://doi.org/10.3969/j.issn.1673-5374.2013.35.007