Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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miR-27a as an Oncogenic microRNA of Hepatitis B Virus-related Hepatocellular Carcinoma

  • Wu, Xin-Jun (Department of General Surgery II, The First Affiliated Hospital of Xinxiang Medical University) ;
  • Li, Yan (Department of General Surgery II, The First Affiliated Hospital of Xinxiang Medical University) ;
  • Liu, Dong (Department of Dermatology, The First Affiliated Hospital of Xinxiang Medical University) ;
  • Zhao, Lun-De (Department of General Surgery II, The First Affiliated Hospital of Xinxiang Medical University) ;
  • Bai, Bin (Department of General Surgery II, The First Affiliated Hospital of Xinxiang Medical University) ;
  • Xue, Ming-Hui (Department of General Surgery II, The First Affiliated Hospital of Xinxiang Medical University)
  • Published : 2013.02.28
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Abstract

microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression through post-transcriptional interactions with mRNA. miRNAs have recently emerged as key regulators of various cancers. Although miR-27a has been implicated in several other cancers, its role in hepatitis B virus-related hepatocellular carcinoma (HCC) is unknown. In this study, we showed miR-27a to be frequently up-regulated in HCC tissues and HCC cell lines (HepG2 and Huh7). Overexpression of miR-27a enhanced cell proliferation, promoted migration and invasion, and activated cell cycling in HepG2 and Huh7 cells. In summary, our results suggest that up-regulation of miR-27a may play an oncogenic role in the development of HCC and might thus be a new therapeutic target in HCC patients.

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References

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