Asian Pacific Journal of Cancer Prevention

  • 제14권4호
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  • Pages.2577-2582
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  • 2013
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Interleukin-10 Gene Promoter Polymorphisms and Risk of Gastric Cancer in a Chinese Population: Single Nucleotide and Haplotype Analyses

  • Pan, Xiong-Fei (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Yang, Shu-Juan (Department of Child and Adolescent Health, West China School of Public Health, Sichuan University) ;
  • Loh, Marie (Cancer Science Institute of Singapore, National University of Singapore) ;
  • Xie, Yao (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Wen, Yuan-Yuan (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Tian, Zhi (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Huang, He (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Lan, Hui (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Chen, Feng (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Soong, Richie (Cancer Science Institute of Singapore, National University of Singapore) ;
  • Yang, Chun-Xia (Department of Epidemiology, West China School of Public Health, Sichuan University)
  • 발행 : 2013.04.30
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초록

Objectives: Interleukin (IL) -10 is a potent cytokine with a dual ability to immunosuppress or immunostimulate. We aimed to explore the association of IL10 promoter polymorphisms with risk of gastric cancer (GC) in a Han population in Southwestern China. Methods: We enrolled 308 pairs of GC and control subjects from four hospitals and a community between October 2010 and August 2011 in a 1:1 matched case-control design. Demographic information was collected using a designed questionnaire. IL10-592 A>C and IL10-1082 A>G polymorphisms were determined by Sequenom MassARRAY analysis. Results: Patients with GC reported statistically higher proportions of family history of cancer (29.9% versus 10.7%, P<0.01) and alcohol drinking (54.6% versus 43.2%, P<0.01) than did controls. Similar results were observed in comparison between non-cardia GC patients and controls (P<0.01 and P=0.03). Variant genotypes of IL10-592 A>C and IL10-1082 A>G were not associated with overall GC risk (adjusted OR, 0.94, 95% CI, 0.66-1.33; adjusted OR, 1.00, 95% CI, 0.62-1.60). Sub-analysis showed that the IL10-592 AC/CC variant genotype was associated with decreased non-cardia GC risk (adjusted OR, 0.58; 95% CI, 0.36-0.95). No association was found between any of the IL10 haplotypes established from two polymorphisms and risk of non-cardia GC. Conclusions: In conclusion, our data do not link the two SNPs of IL10-592 and IL10-1082 with overall GC risk. We demonstrate that IL10-592 polymorphism is associated with protective effect against non-cardia GC. Our findings may offer insight into risk associated with the development of GC in this region.

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참고문헌

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