DOI QR코드

DOI QR Code

Interleukin-10 Gene Promoter Polymorphisms and Risk of Gastric Cancer in a Chinese Population: Single Nucleotide and Haplotype Analyses

  • Pan, Xiong-Fei (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Yang, Shu-Juan (Department of Child and Adolescent Health, West China School of Public Health, Sichuan University) ;
  • Loh, Marie (Cancer Science Institute of Singapore, National University of Singapore) ;
  • Xie, Yao (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Wen, Yuan-Yuan (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Tian, Zhi (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Huang, He (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Lan, Hui (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Chen, Feng (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Soong, Richie (Cancer Science Institute of Singapore, National University of Singapore) ;
  • Yang, Chun-Xia (Department of Epidemiology, West China School of Public Health, Sichuan University)
  • 발행 : 2013.04.30

초록

Objectives: Interleukin (IL) -10 is a potent cytokine with a dual ability to immunosuppress or immunostimulate. We aimed to explore the association of IL10 promoter polymorphisms with risk of gastric cancer (GC) in a Han population in Southwestern China. Methods: We enrolled 308 pairs of GC and control subjects from four hospitals and a community between October 2010 and August 2011 in a 1:1 matched case-control design. Demographic information was collected using a designed questionnaire. IL10-592 A>C and IL10-1082 A>G polymorphisms were determined by Sequenom MassARRAY analysis. Results: Patients with GC reported statistically higher proportions of family history of cancer (29.9% versus 10.7%, P<0.01) and alcohol drinking (54.6% versus 43.2%, P<0.01) than did controls. Similar results were observed in comparison between non-cardia GC patients and controls (P<0.01 and P=0.03). Variant genotypes of IL10-592 A>C and IL10-1082 A>G were not associated with overall GC risk (adjusted OR, 0.94, 95% CI, 0.66-1.33; adjusted OR, 1.00, 95% CI, 0.62-1.60). Sub-analysis showed that the IL10-592 AC/CC variant genotype was associated with decreased non-cardia GC risk (adjusted OR, 0.58; 95% CI, 0.36-0.95). No association was found between any of the IL10 haplotypes established from two polymorphisms and risk of non-cardia GC. Conclusions: In conclusion, our data do not link the two SNPs of IL10-592 and IL10-1082 with overall GC risk. We demonstrate that IL10-592 polymorphism is associated with protective effect against non-cardia GC. Our findings may offer insight into risk associated with the development of GC in this region.

키워드

참고문헌

  1. Akdis M, Burgler S, Crameri R, et al (2011). Interleukins, from 1 to 37, and interferon-gamma: receptors, functions, and roles in diseases. J Allergy Clin Immunol, 127, 701-21 e1-70. https://doi.org/10.1016/j.jaci.2010.11.050
  2. Alpizar-Alpizar W, Perez-Perez GI, Une C, et al (2005). Association of interleukin-1B and interleukin-1RN polymorphisms with gastric cancer in a high-risk population of Costa Rica. Clin Exp Med, 5, 169-76. https://doi.org/10.1007/s10238-005-0082-3
  3. Bai XL, Sun LP, Liu J, et al (2008). Correlation of interleukin-10-1082G/a single nucleotide polymorphism to the risk of gastric cancer in north China: a case-control study [in Chinese]. Chin J Cancer, 27, 35-40.
  4. Bertuccio P, Chatenoud L, Levi F, et al (2009). Recent patterns in gastric cancer: a global overview. Int J Cancer, 125, 666-73. https://doi.org/10.1002/ijc.24290
  5. Blaser MJ (1999). Hypothesis: the changing relationships of Helicobacter pylori and humans: implications for health and disease. J Infect Dis, 179, 1523-30. https://doi.org/10.1086/314785
  6. Brown LM, Devesa SS (2002). Epidemiologic trends in esophageal and gastric cancer in the United States. Surg Oncol Clin N Am, 11, 235-56.
  7. Con SA, Takeuchi H, Con-Chin GR, et al (2009). Role of bacterial and genetic factors in gastric cancer in Costa Rica. World J Gastroenterol, 15, 211-8. https://doi.org/10.3748/wjg.15.211
  8. Crawley E, Kay R, Sillibourne J, et al (1999). Polymorphic haplotypes of the interleukin-10 5' flanking region determine variable interleukin-10 transcription and are associated with particular phenotypes of juvenile rheumatoid arthritis. Arthritis Rheum, 42, 1101-8. https://doi.org/10.1002/1529-0131(199906)42:6<1101::AID-ANR6>3.0.CO;2-Y
  9. Crew KD, Neugut AI (2006). Epidemiology of gastric cancer. World J Gastroenterol, 12, 354-62.
  10. El-Omar EM, Rabkin CS, Gammon MD, et al (2003). Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology, 124, 1193-201. https://doi.org/10.1016/S0016-5085(03)00157-4
  11. Ferlay J, Shin HR, Bray F, et al GLOBOCAN 2008 v2.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10 [Internet], Lyon, France: International Agency for Research on Cancer; 2010. Available from: http://globocan. iarc.fr, accessed on 25/2/2013.
  12. Gibson AW, Edberg JC, Wu J, et al (2001). Novel single nucleotide polymorphisms in the distal IL-10 promoter affect IL-10 production and enhance the risk of systemic lupus erythematosus. J Immunol, 166, 3915-22. https://doi.org/10.4049/jimmunol.166.6.3915
  13. Guo W, Wang N, Wang YM, et al (2005). Interleukin-10-1082 promoter polymorphism is not associated with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in a population of high-incidence region of north China. World J Gastroenterol, 11, 858-62. https://doi.org/10.3748/wjg.v11.i6.858
  14. Jemal A, Center MM, Desantis C, Ward EM (2010). Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol Biomarkers Prev, 19, 1893-907. https://doi.org/10.1158/1055-9965.EPI-10-0437
  15. Justenhoven C, Hamann U, Pesch B, et al (2004). ERCC2 genotypes and a corresponding haplotype are linked with breast cancer risk in a German population. Cancer Epidem Biomar, 13, 2059-64.
  16. Kamangar F, Dores GM, Anderson WF (2006). Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol, 24, 2137-50. https://doi.org/10.1200/JCO.2005.05.2308
  17. Li Z, Zhang Z, He Z, et al (2009). A partition-ligationcombination-subdivision EM algorithm for haplotype inference with multiallelic markers: update of the SHEsis (http://analysis.bio-x.cn). Cell Res, 19, 519-23. https://doi.org/10.1038/cr.2009.33
  18. Liu J, Song B, Wang JL, et al (2011). Polymorphisms of interleukin-10 promoter are not associated with prognosis of advanced gastric cancer. World J Gastroenterol, 17, 1362-7. https://doi.org/10.3748/wjg.v17.i10.1362
  19. Loh M, Koh KX, Yeo BH, et al (2009). Meta-analysis of genetic polymorphisms and gastric cancer risk: variability in associations according to race. Eur J Cancer, 45, 2562-8. https://doi.org/10.1016/j.ejca.2009.03.017
  20. Lu W, Pan K, Zhang L, et al (2005). Genetic polymorphisms of interleukin (IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor {alpha} and risk of gastric cancer in a Chinese population. Carcinogenesis, 26, 631-6.
  21. Mccoll KE, El-Omar E, Gillen D (2000). Helicobacter pylori gastritis and gastric physiology. Gastroenterol Clin North Am, 29, 687-703, viii. https://doi.org/10.1016/S0889-8553(05)70138-2
  22. Mocellin S, Marincola FM, Young HA (2005). Interleukin-10 and the immune response against cancer: a counterpoint. J Leukoc Biol, 78, 1043-51. https://doi.org/10.1189/jlb.0705358
  23. Ni P, Xu H, Xue H, et al (2012). A meta-analysis of interleukin-10-1082 promoter polymorphism associated with gastric cancer risk. DNA Cell Biol, 31, 582-91. https://doi.org/10.1089/dna.2011.1440
  24. Niven DJ, Berthiaume LR, Fick GH, Laupland KB (2012). Matched case-control studies: a review of reported statistical methodology. Clin Epidemiol, 4, 99-110.
  25. Rad R, Dossumbekova A, Neu B, et al (2004). Cytokine gene polymorphisms influence mucosal cytokine expression, gastric inflammation, and host specific colonisation during Helicobacter pylori infection. Gut, 53, 1082-9. https://doi.org/10.1136/gut.2003.029736
  26. Salazar-Onfray F, Lopez MN, Mendoza-Naranjo A (2007). Paradoxical effects of cytokines in tumor immune surveillance and tumor immune escape. Cytokine Growth Factor Rev, 18, 171-82. https://doi.org/10.1016/j.cytogfr.2007.01.015
  27. Seno H, Satoh K, Tsuji S, et al (2007). Novel interleukin-4 and interleukin-1 receptor antagonist gene variations associated with non-cardia gastric cancer in Japan: Comprehensive analysis of 207 polymorphisms of 11 cytokine genes. J Gastroenterol Hepatol, 22, 729-37. https://doi.org/10.1111/j.1440-1746.2007.04934.x
  28. Shi YY, He L (2005). SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res, 15, 97-8. https://doi.org/10.1038/sj.cr.7290272
  29. Shin CM, Kim N, Lee HS, et al (2011). Intrafamilial aggregation of gastric cancer: a comprehensive approach including environmental factors, Helicobacter pylori virulence, and genetic susceptibility. Eur J Gastroenterol Hepatol, 23, 411-7. https://doi.org/10.1097/MEG.0b013e328343b7f5
  30. Sicinschi LA, Lopez-Carrillo L, Camargo MC, et al (2006). Gastric cancer risk in a Mexican population: role of Helicobacter pylori CagA positive infection and polymorphisms in interleukin-1 and-10 genes. Int J Cancer, 118, 649-57. https://doi.org/10.1002/ijc.21364
  31. Turner DM, Williams DM, Sankaran D, et al (1997). An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogenet, 24, 1-8. https://doi.org/10.1111/j.1365-2370.1997.tb00001.x
  32. Wang J, Ding Q, Shi Y, et al (2012). The interleukin-10-1082 promoter polymorphism and cancer risk: a meta-analysis. Mutagenesis, 27, 305-12. https://doi.org/10.1093/mutage/ger078
  33. Wen YY, Pan XF, Loh M, et al (2012). ADPRT Val762Ala and XRCC1 Arg194Trp polymorphisms and risk of gastric cancer in Sichuan of China. Asian Pac J Cancer Prev, 13, 2139-44. https://doi.org/10.7314/APJCP.2012.13.5.2139
  34. Won HH, Kim JW, Kim MJ, et al (2010). Interleukin 10 polymorphisms differentially influence the risk of gastric cancer in East Asians and Caucasians. Cytokine, 51, 73-7. https://doi.org/10.1016/j.cyto.2010.03.007
  35. Wu MS, Wu CY, Chen CJ, et al (2003). Interleukin-10 genotypes associate with the risk of gastric carcinoma in Taiwanese Chinese. Int J Cancer, 104, 617-23. https://doi.org/10.1002/ijc.10987
  36. Yuzhalin A (2011). The role of interleukin DNA polymorphisms in gastric cancer. Hum Immunol, 72, 1128-36. https://doi.org/10.1016/j.humimm.2011.08.003
  37. Zambon CF, Basso D, Navaglia F, et al (2005). Pro-and anti-inflammatory cytokines gene polymorphisms and Helicobacter pylori infection: interactions influence outcome. Cytokine, 29, 141-52. https://doi.org/10.1016/j.cyto.2004.10.013
  38. Zhou Y, Hu W, Zhuang W, Wu X (2011). Interleukin-10-1082 promoter polymorphism and gastric cancer risk in a Chinese Han population. Mol Cell Biochem, 347, 89-93. https://doi.org/10.1007/s11010-010-0616-1
  39. Zhuang W, Wu XT, Zhou Y, et al (2010). Interleukin10-592 promoter polymorphism associated with gastric cancer among Asians: a meta-analysis of epidemiologic studies. Dig Dis Sci, 55, 1525-32. https://doi.org/10.1007/s10620-009-0922-1

피인용 문헌

  1. Association Analysis of Common Genetic Variations in MUC5AC Gene with the Risk of Non-cardia Gastric Cancer in a Chinese Population vol.15, pp.10, 2014, https://doi.org/10.7314/APJCP.2014.15.10.4207
  2. Combined Effects of Six Cytokine Gene Polymorphisms and SNP-SNP Interactions on Hepatocellular Carcinoma Risk in Southern Guangxi, China vol.15, pp.16, 2014, https://doi.org/10.7314/APJCP.2014.15.16.6961
  3. Association of Cytokine Gene Polymorphisms with Gastritis in a Kazakh Population vol.15, pp.18, 2014, https://doi.org/10.7314/APJCP.2014.15.18.7763
  4. Interleukin-4 and -8 Gene Polymorphisms and Risk of Gastric Cancer in a Population in Southwestern China vol.15, pp.7, 2014, https://doi.org/10.7314/APJCP.2014.15.7.2951
  5. Exploring the role and diversity of mucins in health and disease with special insight into non-communicable diseases vol.32, pp.8, 2015, https://doi.org/10.1007/s10719-015-9606-6
  6. The -1082A>G polymorphism in promoter region of interleukin-10 and risk of digestive cancer: a meta-analysis vol.4, pp.1, 2014, https://doi.org/10.1038/srep05335
  7. Interleukin-16 polymorphisms as new promising biomarkers for risk of gastric cancer vol.37, pp.2, 2016, https://doi.org/10.1007/s13277-015-4013-y
  8. ASSOCIATION OF INTERLEUKIN-10 -1082 A/G (RS1800896) POLYMORPHISM WITH SUSCEPTIBILITY TO GASTRIC CANCER: META-ANALYSIS OF 6,101 CASES AND 8,557 CONTROLS vol.55, pp.1, 2018, https://doi.org/10.1590/s0004-2803.201800000-18