DOI QR코드

DOI QR Code

Upregulation of MicroRNA 181c Expression in Gastric Cancer Tissues and Plasma

  • Cui, Mei-Hua (Department of Gastroenterology, Aerospace Center Hospital, Aerospace Clinical Medical College, Peking University) ;
  • Hou, Xiao-Lin (Department of Gastroenterology, Aerospace Center Hospital, Aerospace Clinical Medical College, Peking University) ;
  • Lei, Xiao-Yan (Department of Gastroenterology, Aerospace Center Hospital, Aerospace Clinical Medical College, Peking University) ;
  • Mu, Fang-Hong (Department of Gastroenterology, Aerospace Center Hospital, Aerospace Clinical Medical College, Peking University) ;
  • Yang, Gui-Bin (Department of Gastroenterology, Aerospace Center Hospital, Aerospace Clinical Medical College, Peking University) ;
  • Yue, Lin (Department of Gastroenterology, Aerospace Center Hospital, Aerospace Clinical Medical College, Peking University) ;
  • Fu, Yi (Department of Gastroenterology, Aerospace Center Hospital, Aerospace Clinical Medical College, Peking University) ;
  • Yi, Guo-Xing (Department of Gastroenterology, Aerospace Center Hospital, Aerospace Clinical Medical College, Peking University)
  • 발행 : 2013.05.30

초록

Objective: To test the microRNA-181c (miR-181c) expression in tissues and plasma of gastric cancer (GC) cases, analyze any correlations, and explore the possibility of miR-181c as a potential molecular marker for GC diagnosis. Materials and Methods: Relative miR-181c expression levels in cancers and plasma from 30 GC patients was tested using reverse transcription-real-time fluorescent quantitation PCR and compared to that in samples from 30 gastric ulcer and 30 chronic gastritis patients. Results: The miR-181c expression level in the GC tissues was significantly higher than that in the gastric ulcer and chronic gastritis tissues (P = 0.000), as was the miR-181c expression level in the GC plasma (P = 0.000). We determined that miR-181c expression in GC plasma was positively correlated to its expression in the GC tissues (P = 0.000). Conclusions: The expression of miR-181c is upregulated in GC tissues and plasma, and the miR-181c expression level in GC plasma is positively correlated to that in the corresponding cancer tissues. Plasma miR-181c is possibly a new serological marker for GC diagnosis.

키워드

참고문헌

  1. Brase JC, Wuttig D, Kuner R, et al (2010). Serum microRNAs as non-invasive biomarker for cancer. Mol Cancer, 9, 306. https://doi.org/10.1186/1476-4598-9-306
  2. Cheng H, Zhang L, Cogdell DE, et al (2011). Circulating plasma MiR-141 is a novel biomarker for metastatic colon cancer and predicts poor prognosis. PLoS One, 6, e17745. https://doi.org/10.1371/journal.pone.0017745
  3. Criscitiello C, Sotiriou C, Ignatiadis M (2010). Circulating tumor cells and emerging blood biomarkers in breast cancer. Curr Opin Oncol, 22, 552-8. https://doi.org/10.1097/CCO.0b013e32833de186
  4. Ferlay J, Shin HR, Bray F, et al (2010). Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer, 127, 2893- 917. https://doi.org/10.1002/ijc.25516
  5. Habbe N, Koorstra JB, Mendell JT, et al (2009). MicroRNA miR-155 is a biomarker of early pancreatic neoplasia. Cancer Biol Ther, 8, 340-6. https://doi.org/10.4161/cbt.8.4.7338
  6. Hartgrink HH, Jansen EP, van Grieken NC, et al (2009). Gastric cancer. Lancet, 374, 477-90. https://doi.org/10.1016/S0140-6736(09)60617-6
  7. Hashimoto Y, Akiyama Y, Otsubo T, et al (2010). Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis. Carcinogenesis, 31, 777-84. https://doi.org/10.1093/carcin/bgq013
  8. Jay C, Nemunaitis J, Chen P, et al (2007). miRNA profiling for diagnosis and prognosis of human cancer. DNA Cell Biol, 26, 293- 300. https://doi.org/10.1089/dna.2006.0554
  9. Ji X, Takahashi R, Hiura Y, et al (2009). Plasma miR208 as a biomarker of myocardial injury. Clin Chem, 55, 1944-9. https://doi.org/10.1373/clinchem.2009.125310
  10. Li BS, Zhao YL, Guo G, et al (2012). Plasma microRNAs, miR-223, miR-21 and miR-218, as novel potential biomarkers for gastric cancer detection. PloS One, 7, e41629. https://doi.org/10.1371/journal.pone.0041629
  11. Liu H, Zhu L, Liu B, et al (2012). Genome-wide microRNA profiles identify miR-378 as a serum biomarker for early detection of gastric cancer. Cancer Lett, 316, 196-203. https://doi.org/10.1016/j.canlet.2011.10.034
  12. Liu H, Zhu L, Liu B, et al (2012). Genome-wide microRNA profiles identify miR-378 as a serum biomarker for early detection of gastric cancer. Cancer Lett, 316, 196-203. https://doi.org/10.1016/j.canlet.2011.10.034
  13. Liu R, Zhang C, Hu Z, et al (2011). A five-microRNA signature identified from genome-wide serum microRNA expression profiling serves as a fingerprint for gastric cancer diagnosis. Eur J Cance, 47, 784-91. https://doi.org/10.1016/j.ejca.2010.10.025
  14. Lowery AJ, Miller N, Devaney A, et al (2009). MicroRNA signatures predict oestrogen receptor, progesterone receptor and HER2/neu receptor status in breast cancer. Breast Cancer Res, 11, R27. https://doi.org/10.1186/bcr2257
  15. Mattie MD, Benz CC, Bowers J, et al (2006). Optimized highthroughput microRNA expression profiling provides novel biomarker assessment of clinical prostate and breast cancer biopsies. Mol Cancer, 5, 24. https://doi.org/10.1186/1476-4598-5-24
  16. Mitchell PS, Parkin RK, Kroh EM, et al (2008). Circulating microRNAs as stable blood based markers for cancer detection. Proc Natl Acad Sci USA, 105, 10513-8. https://doi.org/10.1073/pnas.0804549105
  17. Ng EK, Chong WW, Jin H, et al (2009). Differential expression of microRNAs in plasma of patients with colorectal cancer: a potential marker for colorectal cancer screening. Gut, 58, 1375-81. https://doi.org/10.1136/gut.2008.167817
  18. Osman A (2012). MicroRNAs in health and disease-basic science and clinical applications. Clin Lab, 58, 393-402.
  19. Resnick KE, Alder H, Hagan JP, et al (2009). The detection of differentially expressed microRNAs from the serum of ovarian cancer patients using a novel real time PCR platform. Gynecol Oncol, 112, 55-9. https://doi.org/10.1016/j.ygyno.2008.08.036
  20. Slaby O, Lakomy R, Fadrus P, et al (2010). MicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients. Neoplasma, 57, 264-9. https://doi.org/10.4149/neo_2010_03_264
  21. Tsujiura M, Ichikawa D, Komatsu S, et al (2010). Circulating microRNAs in plasma of patients with gastric cancers. Br J Cancer, 102, 1174-9. https://doi.org/10.1038/sj.bjc.6605608
  22. Valadi H, Ekstrom K, Bossios A, et al (2007). Exosomemediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol, 9, 654-9. https://doi.org/10.1038/ncb1596
  23. Wang F, Sun GP, Zou YF, et al (2012). MicroRNAs as promising biomarkers for gastric cancer. Cancer Biomark, 11, 259-67.
  24. Wong TS, Liu XB, Wong BY, et al (2008). Mature miR-184 as potential oncogenic microRNA of squamous cell carcinoma of tongue. Clin Cancer Res, 14, 2588-92. https://doi.org/10.1158/1078-0432.CCR-07-0666
  25. Yang N, Kaur S, Volinia S, et al (2008). MicroRNA microarray identifies Let-7i as a novel biomarker and therapeutic target in human epithelial ovarian cancer. Cancer Res, 68, 10307-14. https://doi.org/10.1158/0008-5472.CAN-08-1954

피인용 문헌

  1. A potential regulatory loop between Lin28B:miR-212 in androgen-independent prostate cancer vol.45, pp.6, 2014, https://doi.org/10.3892/ijo.2014.2647
  2. Differential microRNA expression in aristolochic acid-induced upper urothelial tract cancers ex vivo vol.12, pp.5, 2015, https://doi.org/10.3892/mmr.2015.4330
  3. Tumor suppressor miR-181c attenuates proliferation, invasion, and self-renewal abilities in glioblastoma vol.26, pp.2, 2015, https://doi.org/10.1097/WNR.0000000000000302
  4. Epigenetic silencing of miR-181c by DNA methylation in glioblastoma cell lines vol.16, pp.1, 2016, https://doi.org/10.1186/s12885-016-2273-6
  5. MicroRNA-181c prevents apoptosis by targeting of FAS receptor in Ewing’s sarcoma cells vol.18, pp.1, 2018, https://doi.org/10.1186/s12935-018-0536-9
  6. Decreased MicroRNA miR-181c Expression Associated with Gastric Cancer vol.49, pp.1, 2018, https://doi.org/10.1007/s12029-017-0042-7
  7. MicroRNAs as non-invasive diagnostic biomarkers for gastric cancer: Current insights and future perspectives vol.24, pp.30, 2018, https://doi.org/10.3748/wjg.v24.i30.3313