DOI QR코드

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Meta-analysis of the CYP1A2 -163C>A Polymorphism and Lung Cancer Risk

  • Deng, Sheng-Qiong (Department of Preventive Medicine, Institute of Basic Medical Sciences, Hubei University of Medicine) ;
  • Zeng, Xian-Tao (Department of Stomatology, Taihe Hospital, Hubei University of Medicine) ;
  • Wang, Yun (Department of Respiratory Medicine, Taihe Hospital, Hubei University of Medicine) ;
  • Ke, Qing (Department of Oncology, Taihe Hospital, Hubei University of Medicine) ;
  • Xu, Qiong-Li (Department of Stomatology, Taihe Hospital, Hubei University of Medicine)
  • 발행 : 2013.05.30

초록

Many published studies have concerned associations between the CYP1A2 -163 C>A polymorphism and risk of lung cancer, but the results have been inconsistent. Therefore, we performed a meta-analysis to obtain a more precise estimate. We searched the PubMed database up to March 1, 2013 for relevant cohort and case-control studies. Supplementary search was conducted manually by searching the references of the included studies and relevant meta-analyses. A meta-analysis was performed using RevMan 5.2 software for calculation of pooled odds ratios (ORs) and relevant 95% confidence intervals (CIs) after data extraction. Finally, seven case-control studies and one nested case-control study involving 1,675 lung cancer patients and 2,393 controls were included. The meta-analysis showed that there was no association of CYP1A2 -163 C>A polymorphism with risk of lung cancer overall [(OR=0.89, 95%CI= 0.74-1.07) for C vs. A; (OR=0.73, 95%CI= 0.50-1.07) for AA vs. CC ; (OR=0.82, 95%CI= 0.62-1.09) for AC vs. CC; (OR=0.79, 95%CI= 0.58-1.07) for (AC+AA) vs. CC; and (OR=0.87, 95%CI= 0.67-1.13) for AA vs. (CC+AC)]. Subgroup analysis indicated that there was an associationbetween CYP1A2 -163C>A polymorphism and lung cancer risk for population-based controls, a trend risk for SCCL (squamous cell carcinoma of lung) and Caucasians. These results suggested that -163 C>A polymorphism is likely to be associated with risk of lung cancer compared with population-based controls.

키워드

참고문헌

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피인용 문헌

  1. Four Polymorphisms in the Cytochrome P450 1A2 (CYP1A2) Gene and Lung Cancer Risk: a Meta-analysis vol.15, pp.14, 2014, https://doi.org/10.7314/APJCP.2014.15.14.5673
  2. Lack of association between polymorphisms in the CYP1A2 gene and risk of cancer: evidence from meta-analyses vol.16, pp.1, 2016, https://doi.org/10.1186/s12885-016-2096-5