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Evaluation of Human Papillomavirus Infections in Prostatic Disease: a Cross-Sectional Study in Iran

  • Ghasemian, Ehsan (Department of Microbiology, Science and Research Branch, Islamic Azad University) ;
  • Monavari, Seyed Hamid Reza (Department of Virology, Faculty of Medicine and Antimicrobial Resistance Research Center, Tehran University of Medical Sciences) ;
  • Irajian, Gholam Reza (Department of Microbiology, School of Medicine, Shahed University) ;
  • Nodoshan, Mohammad Reza Jalali (Department of Pathology, School of Medicine, Shahed University) ;
  • Roudsari, Rouhollah Vahabpour (Department of Virology, Faculty of Medicine and Antimicrobial Resistance Research Center, Tehran University of Medical Sciences) ;
  • Yahyapour, Yousef (Department of Virology, Faculty of Medicine and Antimicrobial Resistance Research Center, Tehran University of Medical Sciences)
  • 발행 : 2013.05.30

초록

Background: The role of inflammation in prostate diseases is suggested by the presence of inflammatory cells within the prostate in benign prostatic hyperplasia (BPH) and prostate cancer (PCa) patients. In addition, bacterial and viral infection may lead to chronic and recurrent inflammation of the prostate. The human papillomaviruses (HPVs) are a family of sexually transmitted viruses which have been implicated in the aetiology of cervical cancer and several other malignancies. This study evaluated the frequency of HPV infection in individuals with prostatic disease in Iran. Materials and Methods: The study included formalin fixed paraffin- embedded tissue samples of 196 primary prostate cases, including 29 PCa and 167 BPH samples. HPV DNA was purified and amplified through MY09/MY11 and GP5+/GP6+ primers with nested PCR. All patients were interviewed using a questionnaire to collect demographic information. Results: Nested PCR showed that HPV DNA was found in 17.2 percent of PCa samples and 4.8 percent of BPH samples (not significant). Conclusions: Our data do not support a significant role of HPV infection in prostatic disease in Iranian patients, but demographic data indicated a probable association between presence of HPV DNA and risk of inflammation in prostate tissue which might lead to prostate carcinoma. Further studies are required to elucidate any roles of HPV infection in prostatic disease.

키워드

참고문헌

  1. Adami HO, Kuper H, Andersson SO, Bergstrom R, Dillner J (2003). Prostate cancer risk and serologic evidence of human papilloma virus infection: a population-based case-control study. Cancer Epidemiol Biomarkers Prev, 12, 872-5.
  2. Aghakhani A, Hamkar R, Parvin M, et al (2011). The role of Human papillomavirus infection in prostate carcinoma. Scand J Infect Dis, 43, 64- 9. https://doi.org/10.3109/00365548.2010.502904
  3. Anwar K, Nakakuki K, Shiraishi T, et al (1992). Presence of ras oncogene mutations and Human papillomavirus DNA in human prostate carcinomas. Cancer Res, 52, 5991-6.
  4. Chen AC, Waterboer T, Keleher A, et al (2011). Human papillomavirus in benign prostatic hyperplasia and prostatic adenocarcinoma patients. Pathol Oncol Res, 17, 613-7. https://doi.org/10.1007/s12253-010-9357-4
  5. Dell G, Gaston K (2001). Contributions in the domain of cancer research: ReviewHuman papillomavirus es and their role in cervical cancer. CMLS, 58, 12-3.
  6. Dodd JG, Paraskevas M, McNicol PJ (1993). Detection of Human papillomavirus 16 transcription in human prostate tissue. J Urol, 149, 400-2.
  7. Gazzaz FS, Mosli HA (2009). Lack of detection of Human papillomavirus infection by hybridization test in prostatic biopsies. Saudi Med J, 30, 633-7.
  8. Goldenberg D, Begum S, Westra WH, et al (2008). Cystic lymph node metastasis in patients with head and neck cancer: An HPV-associated phenomenon. Head Neck, 30, 898-903. https://doi.org/10.1002/hed.20796
  9. Grivennikov SI, Greten FR, Karin M (2010). Immunity, inflammation, and cancer. Cell, 140, 883-99. https://doi.org/10.1016/j.cell.2010.01.025
  10. Hamid AR, Umbas R, Mochtar CA (2011). Recent role of inflammation in prostate diseases: chemoprevention development opportunity. Acta Med Indones, 43, 59-65.
  11. Hrbacek J, Urban M, Hamsikova E, et al (2011). Serum antibodies against genitourinary infectious agents in prostate cancer and benign prostate hyperplasia patients: a casecontrol study. BMC Cancer, 11, 53. https://doi.org/10.1186/1471-2407-11-53
  12. Karin AR, Joseph JC, Lori MI, et al (2003). Serologic evidence of Human papillomavirus 16 and 18 infectiond and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev, 12, 763-8.
  13. Korodi Z, Dillner J, Jellum E, et al (2005). Human papillomavirus 16, 18 and 33 infections and risk of prostate cancer: a Nordic nested case control study. Cancer Epidemiol Biomarkers Prev, 14, 2952-5. https://doi.org/10.1158/1055-9965.EPI-05-0602
  14. Prakash K, Pirozzi G, Elashoff M, et al (2002). Symptomatic and asymptomatic benign prostatic hyperplasia: Molecular differentiation by using microarrays. PNAS, 99, 7598-7603. https://doi.org/10.1073/pnas.112191399
  15. Leiros AJ, Galliano SR, Sember ME, Kahn T, Schwarz E, Eiguchi K (2005). Detection of Human papillomavirus DNA and p53 codon 72 polymorphism in prostate carcinomas of patients from Argentina. BMC Urology, 5, 15. https://doi.org/10.1186/1471-2490-5-15
  16. Maghrabi JAA (2007). The role of Human papillomavirus infection in prostate cancer. Saudi Med J, 28, 326-33.
  17. Marklund L, Hammarstedt L (2011). Impact of HPV in oropharyngeal cancer. J Oncol, 10, 509036
  18. Martinez-Fierro ML, Leach RJ, Gomez-Guerra LS, et al (2010). Identification of viral infections in the prostate and evaluation of their association with cancer. BMC Cancer, 10, 326. https://doi.org/10.1186/1471-2407-10-326
  19. McNicol PJ, Dodd JG (1991). High prevalence of Human papillomavirus in prostate tissues. J Urol,145, 850-3.
  20. Noda T, Sasagawa T, Dong Y, et al (1998). Detection of Human papillomavirus (HPV) DNA in archival specimens of benign prostatic hyperplasia and prostatic cancer using a highly sensitive nested PCR method. Urol Res, 26, 165-9. https://doi.org/10.1007/s002400050041
  21. Schindl M, Bachtiary B, Dreier B, et al (2001). Impact of Human papillomavirus infection on the expression of the KAI1 metastasis suppressor protein in invasive cervical cancer. Cancer Lett, 26, 261-6.
  22. Silvestre RVD, Leal MF, Demachki S, et al (2009). Low frequency of Human papillomavirus detection in prostate tissue from individuals from Northern Brazil. Mem Inst Oswaldo Cruz, 104, 665-7. https://doi.org/10.1590/S0074-02762009000400024
  23. Smelov V, van Moorselaar J, Startsev V, et al (2011). No high-risk Human papillomavirus infection in prostate cancer tissues. Scand J Infect Dis, 43, 399-400. https://doi.org/10.3109/00365548.2011.552071
  24. Stamatiou K (2009). Management of benign prostatic hypertrophy related urinary retention current trends and perspectives. Urology J, 6, 237-44.
  25. Tu H, Jacobs SC, Mergner WJ, Kyprianou N (1994). Rare incidence of Human papillomavirus types 16 and 18 in primary and metastatic human prostate cancer. Urology, 44, 726-31. https://doi.org/10.1016/S0090-4295(94)80215-7
  26. Webber R (2006). Benign prostatic hyperplasia. Clinical Evidence, 41, 1-31.
  27. Yahyapour Y, Shamsi-Shahrabadi M, Mahmoudi M, et al (2012). High-risk and low-risk Human papillomavirus in esophageal squamous cell carcinoma at Mazandaran, Northern Iran. Pathol Oncol Res, [Epub ahead of print].
  28. Yahyapour Y, Shamsi-Shahrabadi M, Mahmoudi M, et al (2012). Evaluation of human papilloma virus infection in patients with esophageal squamous cell carcinoma from the Caspian Sea area, north of Iran. Asian Pac J Cancer Prev, 13, 1261-6. https://doi.org/10.7314/APJCP.2012.13.4.1261

피인용 문헌

  1. Human Papillomavirus Burden in Different Cancers in Iran: a Systematic Assessment vol.15, pp.17, 2014, https://doi.org/10.7314/APJCP.2014.15.17.7029
  2. The Aetiological Role of Human Papillomavirus in Colorectal Carcinoma: An Iranian Population- Based Case Control Study vol.15, pp.4, 2014, https://doi.org/10.7314/APJCP.2014.15.4.1521
  3. Presence of Human Papillomavirus DNA in Colorectal Cancer Tissues in Shiraz, Southwest Iran vol.16, pp.17, 2015, https://doi.org/10.7314/APJCP.2015.16.17.7883
  4. Site of infections associated with human papillomavirus vol.291, pp.3, 2015, https://doi.org/10.1007/s00404-014-3480-5
  5. Lack of detection of human papillomavirus DNA in prostate carcinomas in patients from northeastern Brazil vol.39, pp.1, 2016, https://doi.org/10.1590/1678-4685-GMB-2015-0122
  6. Lack of evidence of HPV etiology of prostate cancer following radical surgery and higher frequency of the Arg/Pro genotype in turkish men with prostate cancer vol.43, pp.1, 2017, https://doi.org/10.1590/s1677-5538.ibju.2015.0429
  7. Association between human papillomavirus and prostate cancer: A meta-analysis vol.14, pp.2, 2017, https://doi.org/10.3892/ol.2017.6367
  8. Association between human papillomavirus infection and prostate cancer: A global systematic review and meta-analysis pp.17437555, 2019, https://doi.org/10.1111/ajco.13124