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Absence of EZH2 Gene Mutation in Chronic Myeloid Leukemia Patients in Blast Crisis

  • Chen, Hao-Yue (Jingjiang People's Hospital, the Seventh Affiliated Hospital of Yangzhou University) ;
  • Yao, Hong (Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University) ;
  • Wu, Ling-Yu (Jingjiang People's Hospital, the Seventh Affiliated Hospital of Yangzhou University) ;
  • Liu, Can-Jun (Jingjiang People's Hospital, the Seventh Affiliated Hospital of Yangzhou University) ;
  • Zhu, Jian-Qin (Jingjiang People's Hospital, the Seventh Affiliated Hospital of Yangzhou University) ;
  • Liu, Chun-Hua (Jingjiang People's Hospital, the Seventh Affiliated Hospital of Yangzhou University) ;
  • Wang, Wei (Jingjiang People's Hospital, the Seventh Affiliated Hospital of Yangzhou University) ;
  • Dong, Sha-Sha (Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University) ;
  • Ping, Na-Na (Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University) ;
  • Chen, Su-Ning (Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University) ;
  • Sun, Miao (Jingjiang People's Hospital, the Seventh Affiliated Hospital of Yangzhou University)
  • 발행 : 2013.05.30

초록

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참고문헌

  1. Ernst T, Chase AJ, Score J, et al (2010). Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat Genet, 42, 722-6. https://doi.org/10.1038/ng.621
  2. Ernst T, Pflug A, Rinke J, et al (2012). A somatic EZH2 mutation in childhood acute myeloid leukemia. Leukemia, 26, 1701-3. https://doi.org/10.1038/leu.2012.16
  3. Grossmann V, Bacher U, Kohlmann A, et al (2012). EZH2 mutations and their association with PICALMMLLT10 positive acute leukaemia. Br J Haematol, 157, 387-90. https://doi.org/10.1111/j.1365-2141.2011.08986.x
  4. Grossmann V, Kohlmann A, Zenger M, et al (2011). A deep-sequencing study of chronic myeloid leukemia patients in blast crisis (BC-CML) detects mutations in 76.9% of cases. Leukemia, 25, 557-60. https://doi.org/10.1038/leu.2010.298
  5. Guglielmelli P, Biamonte F, Score J, et al (2011). EZH2 mutational status predicts poor survival in myelofibrosis. Blood, 118, 5227-34. https://doi.org/10.1182/blood-2011-06-363424
  6. Jankowska AM, Makishima H, Tiu RV, et al (2011). Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A. Blood, 118, 3932-41. https://doi.org/10.1182/blood-2010-10-311019
  7. Makishima H, Jankowska AM, McDevitt MA, et al (2011). CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia. Blood, 117, e198-206. https://doi.org/10.1182/blood-2010-06-292433
  8. Makishima H, Jankowska AM, Tiu RV, et al (2010). Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies. Leukemia, 24, 1799-804. https://doi.org/10.1038/leu.2010.167
  9. Morin RD, Johnson NA, Severson TM, et al (2010). Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat Genet, 42, 181-5. https://doi.org/10.1038/ng.518
  10. Zhang SJ, Ma LY,Huang QH, et al (2008). Gain-offunction mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemia. Proc Natl Acad Sci USA, 105, 2076-81. https://doi.org/10.1073/pnas.0711824105