DOI QR코드

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Survival in Patients Treated with Definitive Chemo-Radiotherapy for Non-Metastatic Esophageal Cancer in North-West Iran

  • Mirinezhad, Seyed Kazem (Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences) ;
  • Somi, Mohammad Hossein (Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences) ;
  • Seyednezhad, Farshad (Radiation Oncology Therapy of IMAM REZA (AS) Hospital, Tabriz University of Medical Sciences) ;
  • Jangjoo, Amir Ghasemi (Radiation Oncology Therapy of IMAM REZA (AS) Hospital, Tabriz University of Medical Sciences) ;
  • Ghojazadeh, Morteza (Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences) ;
  • Mohammadzadeh, Mohammad (Radiation Oncology Therapy of IMAM REZA (AS) Hospital, Tabriz University of Medical Sciences) ;
  • Naseri, Ali Reza (Radiation Oncology Therapy of IMAM REZA (AS) Hospital, Tabriz University of Medical Sciences) ;
  • Nasiri, Behnam (Radiation Oncology Therapy of IMAM REZA (AS) Hospital, Tabriz University of Medical Sciences)
  • 발행 : 2013.03.30

초록

Background: Areas of Iran have among the highest incidences of esophageal cancer in the world. Definitive chemo-radiotherapy (DCRT) is used for locally advanced esophageal cancer and for inoperable tumors asan alternative to surgical treatment. Materials and Methods: This retrospective study was conducted in North-West Iran 2006-2011, including 267 consecutive patients with non-metastatic esophageal cancer. Eligible inoperable patients were treated with DCRT or definitive radiotherapy (DRT) alone. Radiotherapy (RT) was delivered at 1.8-2 Gy/day for five consecutive days in a given week. Chemotherapy (CT) consisted of cisplatin and 5-fluorouracil. Results: The median survival was 12.7 months with 1, 3 and 5 year survival rates of 55%, 18% and 11%, respectively. On univariate analysis, relations with age at diagnosis (p=0.015), N-stage (p=0.04), total dose of RT (p=0.001), fraction (p<0.001), Gap status (p=0.025), chemotherapeutic regimens (P=0.027), and 5-Fu $Mg/m^2$ (P=0.004) were apparent. Comparing DCRT to DRT, there was a significant difference in survival. Multivariate analysis was performed for comparison between DCRT and DRT showed significant association with age group ${\geq}65$ to <65 (P=0.02; OR: 1.46), the total RT dose (Gy) ${\geq}50$ to <50 (P=0.01; OR: 0.65) and the fraction group ${\geq}25$ to <25 (P=<0.001; OR: 0.54). Conclusions: The survival rates of esophageal cancer treated with DCRT in North West of Iran is poor; therefore, early detection and improved treatment methods, with clinical trials are a high priority.

키워드

참고문헌

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피인용 문헌

  1. Patterns of Failure after Radical Surgery among Patients with Thoracic Esophageal Squamous Cell Carcinoma: Implications for the Clinical Target Volume Design of Postoperative Radiotherapy vol.9, pp.5, 2014, https://doi.org/10.1371/journal.pone.0097225
  2. A Meta-Analysis of Concurrent Chemoradiotherapy for Advanced Esophageal Cancer vol.10, pp.6, 2015, https://doi.org/10.1371/journal.pone.0128616
  3. Feasibility and Efficacy of Concurrent Chemoradiotherapy in Elderly Patients with Esophageal Squamous Cell Carcinoma: a Respective Study of 116 Cases from a Single Institution vol.16, pp.4, 2015, https://doi.org/10.7314/APJCP.2015.16.4.1463