Asian Pacific Journal of Cancer Prevention

  • 제14권3호
  • /
  • Pages.1761-1768
  • /
  • 2013
  • /
  • 1513-7368(pISSN)
  • /
  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
권호 표지
DOI QR코드

DOI QR Code

Quality of Life and Chemotherapy-related Symptoms of Turkish Cancer Children Undergoing Chemotherapy

  • 발행 : 2013.03.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

This cross-sectional and descriptive study was designed to determine symptoms emerging due to chemotherapy treatment and their effects on children's quality of life. The research was carried out between February 2008 and February 2009 at the pediatric oncology clinics in four hospitals, focusing on 93 patients receiving chemotherapy. A survey form, the Pediatric Quality of Life Inventory (PedsQL 4.0) and the Memorial Symptom Assessment Scale (MSAS) were used as data collection tools. Chi-square and Student t tests were performed for data analysis. Some 51.6% of the children were aged 13-15 years old, and 51.8% were boys and 50.5% were diagnosed as having solid tumors. There were significant relations between: antimetabolite chemotherapeutics and feeling irritable and worrying (p=0.001, p=0.030); vinkoalkaloid and numbness/tingling in hands/feet (p=0.043); antracyclines and lack of energy and skin changes (p=0.021, p=0.004); and corticosteroids and lack of appetite, nausea and sadness (p=0.008, p=0.009, p=0.009). Several symptoms such as feeling sad, worrying and feeling irritable caused a significant decrease in the total domain of quality of life scores (p=0.034, p=0.012, p=0.010, respectively). Chemotherapeutic drugs can cause symptoms that can seriously affect quality of life in children.

키워드

참고문헌

  1. Andersen C, Adamsen L, Moeller T, et al (2006). The effect of a multidimensional exercise programme on symptoms and side-effects in cancer patients undergoing chemotherapy–the use of semi-structured diaries. Eur J Oncol Nur, 10, 247-62. https://doi.org/10.1016/j.ejon.2005.12.007
  2. Atay S, Conk Z, Bahar Z (2012). Identifying symptom clusters in paediatric cancer patients using the memorial symptom assessment scale. Eur J Cancer Care, 21, 460-8
  3. Beker B (2009). Pediatric Oncology. Chemotherapy. (eds Ozkan A.), pp. 279-29. Nobel Tip Kitabevleri, İstanbul, Turkey.
  4. Beker B (2007). Chemotherapy of childhood cancers. Klinik Gelisim, 20, 202-10.
  5. Bektas HA, Akdemir N (2006). The assessment of functional status in individual's who have cancer. Turkiye Klinikleri J Med Sci, 26, 488-99.
  6. Bergkvist K, WengstrOm Y (2006). Symptom experiences during chemotherapy treatment- with focus on nausea and vomiting. Eur J Oncol Nur, 10, 2-29.
  7. Beser GN, Oz F (2003). Anxiety-depression levels and quality of life of patients with lymphoma who are curing chemotherapy. Cumhuriyet Universitesi Hemsirelik Yuksek Okulu Dergisi, 7, 47-58.
  8. Burns DS (2001). A pilot study into the therapeutic effects of music therapy at a cancer help center. Alternative Therapies in Health and Medicine, 7, 48-56.
  9. Campbell B, Wirth A, Milner A, et al (2005). Long-term follow-up of salvage radiotherapy in Hodgkin's lymphoma after chemotherapy failure. Int J Radiation Oncol Biology Physics, 63, 1538-45. https://doi.org/10.1016/j.ijrobp.2005.05.006
  10. Can G (2005). Side effects of antineoplastic drugs and nursing approaches. Hemsirelikte Egitim ve Arastirma Dergisi, 2, 8-15.
  11. Chou F, Dodd M, Abrams D, Padilla G (2007). Symptoms, selfcare, and qualitiy of life of chinese american patients with cancer. Oncol Nur Forum, 34, 1162-7. https://doi.org/10.1188/07.ONF.1162-1167
  12. Collins JJ, Devine DT, Dick GS, et al (2002). The measurement of symptoms in young children with cancer: the validation of the memorial symptom assessment scale in children aged 7-12. J Pain Symptom Management, 23, 10-6. https://doi.org/10.1016/S0885-3924(01)00375-X
  13. Collins JJ, Byrnes ME, Dunkel IJ (2000). The measurement of symptoms in children with cancer. J Pain Symptom Management, 19, 363-77. https://doi.org/10.1016/S0885-3924(00)00127-5
  14. De Bolle M, De Clercq B, De Fruyt F, Benoit Y (2008). Selfand parental perspectives on quality of life in children with cancer. J Psychosoc Oncol, 26, 35-47. https://doi.org/10.1300/J077v26n02_03
  15. Duggleby W (2000). Enduring suffering: a grounded theory analysis of the pain experience of elderly hospice patients with cancer. Oncol Nur Forum, 27, 825-30.
  16. ElCigil A, Conk Z (2010). Determining the burden of mothers with children who have cancer. Dokuz Eylul Universitesi Hemsirelik Yuksek Okulu Elektronik Dergisi, 3, 175-81.
  17. Er M (2006). Cocuk, hastalik, anne-babalar ve kardesler (Child, illness, parent siblings). Cocuk Sagligi ve Hastaliklari Dergisi, 49, 155-68.
  18. Erdem E (2006). The evaluation of nursing interventions provided to the families of children with cancer at home. Hacettepe universitesi Saglik Bilimleri Enstitusu Yayinlanmamis Doktora Tezi, Ankara.
  19. Ferrell BR (1995). The impact of pain on quality of life: a decade of research. Nur Clinics of North Am, 30, 609-24.
  20. Fulcher CD (2006). Depression management during cancer treatment. Oncol Nur Forum, 33, 33-5. https://doi.org/10.1188/06.ONF.33-35
  21. Hansson H, Kjaergaard H, Johansen C, et al (2013). Hospitalbased home care for children with cancer: feasibility and psychosocial impact on children and their families. Pediatr Blood Cancer, 244, 74.
  22. HedstrOm M, Ljungman G, Essen L (2005). Perceptions of distress among adolescents recently diagnosed with cancer. J Hematology Oncol, 14, 15-21.
  23. Hockenberry MJ, Hooke MC, Gregurich M, et al (2010). Symptom clusters in children and adolescents receiving cisplatin, doxorubicin, or ifosfamide. Oncol Nur Forum, 37, 16-25. https://doi.org/10.1188/10.ONF.E16-E27
  24. Hockenberry MJ, Hooke MC (2007) Symptom clusters in children with cancer. Seminars in Oncol Nur, 23, 152-7. https://doi.org/10.1016/j.soncn.2007.01.001
  25. Hongo T, Watanabe C, Okada S, et al (2003). Analysis of the circumstances at the end of life in children with cancer:symptoms, suffering and acceptance. Pediatrics Int, 45, 60-4. https://doi.org/10.1046/j.1442-200X.2003.01668.x
  26. Kaleyias J, Manley P, Kothare SV (2012). Sleep disorders in children with cancer. Semin Pediatr Neurol, 19, 25-34. https://doi.org/10.1016/j.spen.2012.02.013
  27. Kantar M, Ozbaran B, Demirag, et al (2008). Development of obsessive-compulsive and psychotic symptoms in an adolescent with non-hodgkin's lymphoma: is it treatment related? Ege Pediatri Bulteni, 15, 223-7.
  28. Kerr LMJ, Harrison MB, Medves J, et al (2007). Understanding the supportive care needs of parents of children with cancer:an approach to local needs assessment. J Pediatric Oncol Nur, 24, 279-93. https://doi.org/10.1177/1043454207304907
  29. Klaassen RJ, Barr DB, Hughes JBA, et al (2010). Nurses provide valuable proxy assessment of the health-related quality of life of children with Hodgkin disease. Cancer, 116, 1602-7. https://doi.org/10.1002/cncr.24888
  30. Krull KR, Hockenberry MJ, Miketova P, et al (2013). Chemotherapy-related changes in central nervous system phospholipids and neurocognitive function in childhood acute lymphoblastic leukemia. Leuk Lymphoma, 54, 535-40. https://doi.org/10.3109/10428194.2012.717080
  31. Linder LA (2005). Measuring physical symptoms in children and adolescents with cancer. Cancer Nur, 28, 16-26. https://doi.org/10.1097/00002820-200501000-00003
  32. Matzioua V, Perdikarisb P, Felonic D, et al (2008). Cancer in childhood: children's and parents' aspects for quality of life. Eur J Oncol Nur, 12, 209-16. https://doi.org/10.1016/j.ejon.2007.10.005
  33. Meeske KA, Patel SK, Palmer SN, et al (2007). Factors associated with health-related quality of life in pediatric cancer survivors. Pediatr Blood Cancer, 49, 298-305. https://doi.org/10.1002/pbc.20923
  34. Miller MM, Kearney N (2001). Oral care for patients with cancer:a review of the literature. Cancer Nur, 24, 241-54. https://doi.org/10.1097/00002820-200108000-00001
  35. Nagel T (2004). Help patients cope with chemo. Res Nur, 67, 28-30.
  36. Paice JA (2004). Assessment of symptom clusters in people with cancer. J National Cancer Institute Monographs, 32, 98-102.
  37. Pizzo PA, Poplack DG (2001) Principles and practice of pediatric oncology. Lippincott Williams & Wilkin, USA.
  38. Pound CM, Clark C, Ni A, et al (2012). Corticosteroids, behavior, and quality of life in children treated for acute lymphoblastic leukemia; a multicentered trial. J Pediatr Hematol Oncol, 34, 517-23. https://doi.org/10.1097/MPH.0b013e318257fdac
  39. Renbarger JL, McCammack KC, Rouse CEBA, Hall SD (2008). Effect of race on vincristine-associated neurotoxicity in pediatric acute lymphoblastic leukemia patients. Pediatr Blood Cancer, 50, 769-71. https://doi.org/10.1002/pbc.21435
  40. Rodgersa CC, Hookeb MC, Hockenberry MJ (2013). Symptom clusters in children. Curr Opin Support Palliat Care, 7, 67-72 https://doi.org/10.1097/SPC.0b013e32835ad551
  41. Santucci G, Mack J (2007). Common gastrointestinal symptoms in pediatric palliative care: nausea, vomiting, constipation, anorexia, cachexia. Pediatric Clinics of North Am, 54, 673-89. https://doi.org/10.1016/j.pcl.2007.06.001
  42. Savage E, Riordan AO, Hughes M (2008) Quality of life in children with acute lymphoblastic leukemia: a systematic review. Eur J Oncol Nur, 13, 36-48.
  43. Stone P, Ream E, Richardson A, et al (2003). Cancer-, related fatigue –a difference of opinion? results of a multicentre survey of healthcare professionals, patients and caregivers. Eur J Cancer Care, 12, 20-7. https://doi.org/10.1046/j.1365-2354.2003.00329.x
  44. Tas F, Basbakkal Z (2009). Symptoms experienced by children who received chemotherapy and parental applications towords symptom management. Ege Pediatri Bulteni, 16, 33-44.
  45. Tas F, Yilmaz HB (2008). Quality of life concept in pediatric oncology patients. Turk Onkoloji Dergisi, 23, 104-7.
  46. Thatcher N, Qian W, Clark PI, et al (2005). Ifosfamide, carboplatin, and etoposide with midcycle vincristine versus standard chemotherapy in patients with small-cell lung cancer and good performance status: clinical and quality-oflife results of the british medical research council multicenter randomized LU21 trial. J Clin Oncol, 23, 8371-9. https://doi.org/10.1200/JCO.2004.00.9969
  47. Theunissen JMJ, Hoogerbrugge PM, Achterberg TV (2007). Symptoms in the palliative phase of children with cancer. Pediatr Blood Cancer, 49, 160-5. https://doi.org/10.1002/pbc.21042
  48. Tremolada M, Bonichini S, Altoè G, et al (2011). Parental perceptions of health-related quality of life in children with leukemia in the second week after the diagnosis: a quantitative model. Support Care Cancer, 19, 591-8. https://doi.org/10.1007/s00520-010-0854-5
  49. Upton P, Eiser C, Cheung I, et al (2005). Measurement properties of the un-English version of the pediatric quality of life inventory 4.0 (PedsQL) generic gore scales. Health and Quality of Life Outcomes, 3, 1-7. https://doi.org/10.1186/1477-7525-3-1
  50. Uyar M, Uslu R, Yildirim KY (2006). Cancer and palliative care. pp. 5- 405, Meta Basim, Izmir, Turkey.
  51. Waldon EG (2001). The effects of group music therapy on mood states and cohesiveness in adult oncology patients. J Music Therapy, 38, 212-38. https://doi.org/10.1093/jmt/38.3.212
  52. Wong DL, Hockenberry MJ (2003). Wong's nursing care of infants and children, pp. 905-974, 1584-1635, Mosby Inc., USA.
  53. Woodgate RL (2008). Feeling states: a new approach to understanding how children and adolescents with cancer experience symptoms. Cancer Nur, 31, 229-38. https://doi.org/10.1097/01.NCC.0000305731.95839.ca
  54. Woodgate RL, Degner LF (2003). Expectations and beliefs about children's cancer symptoms: perspective of children with cancer and their families. Oncol Nur orum, 30, 479-91. https://doi.org/10.1188/03.ONF.479-491
  55. Varni JW, Seid M, Knight TS (2002). PedsQL TM 4.0 generic core scales: sensitivity, responsiveness, and impact on clinical decisionmaking. J Behavioral Med, 25, 175-93. https://doi.org/10.1023/A:1014836921812
  56. Varn JW, Seid M, Kurtin PS (2001). The pedsQL 4.0TM: reliability and validity of the pediatric quality of life inventorytm version 4.0 generic core scales in healthy and patient populations. Medical Care, 39, 800-12. https://doi.org/10.1097/00005650-200108000-00006
  57. von Lutzau P, Otto M, Hechler T, et al (2012). Children dying from cancer: parents' perspectives on symptoms, quality of life, characteristics of death, and end-of-life decisions. J Palliat Care, 28, 274-81.
  58. Yilmaz BH, Muslu KG, Tas F, et al (2009). Parental views regarding symptoms in children with cancer and recognition of cancer-related fatigue. Turk Onkoloji Dergisi, 24, 122-7.
  59. Yoruk A, Yukselgungor H (2003). Chemotherapy induced transverse leukonychia in children. Int J Dermatology, 42, 468-9. https://doi.org/10.1046/j.1365-4362.2003.01727.x
  60. Zebrack BJ, Chesler MA (2002). Quality of life in childhood cancer survivors. Psycho-Oncology, 11, 132-41. https://doi.org/10.1002/pon.569

피인용 문헌

  1. Side Effects of Chemotherapy among Cancer Patients in a Malaysian General Hospital: Experiences, Perceptions and Informational Needs from Clinical Pharmacists vol.15, pp.13, 2014, https://doi.org/10.7314/APJCP.2014.15.13.5305
  2. Symptom Frequency of Children with Cancer and Parent Quality of Life in Turkey vol.15, pp.8, 2014, https://doi.org/10.7314/APJCP.2014.15.8.3487
  3. Developing a Scale for the Assessment of Fatigue in Pediatric Oncology Patients Aged 7-12 for Children and Parents vol.15, pp.23, 2015, https://doi.org/10.7314/APJCP.2014.15.23.10199
  4. Developing a Scale for Quality of Life in Pediatric Oncology Patients Aged 7-12 - Children and Parent Forms vol.16, pp.2, 2015, https://doi.org/10.7314/APJCP.2015.16.2.523
  5. Self-reported Pain in Adolescents With Leukemia or a Brain Tumor vol.38, pp.5, 2015, https://doi.org/10.1097/NCC.0000000000000214
  6. Quality of life in children with adverse drug reactions: a narrative and systematic review vol.80, pp.4, 2015, https://doi.org/10.1111/bcp.12423
  7. Trajectories of Symptom Clusters, Performance Status, and Quality of Life During Concurrent Chemoradiotherapy in Patients With High-Grade Brain Cancers pp.0162-220X, 2016, https://doi.org/10.1097/NCC.0000000000000435
  8. The effect of symptom frequency on the fatigue and sleep quality of adolescent cancer patients vol.46, pp.4, 2017, https://doi.org/10.1080/02739615.2016.1227936
  9. Aprepitant in pediatric patients using moderate and highly emetogenic protocols: a systematic review and meta-analyses of randomized controlled trials vol.83, pp.5, 2017, https://doi.org/10.1111/bcp.13193