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Study of Autoantibody Concentration Distribution by Thyroid Fine Needle Aspiration Biopsy

갑상선 조직 검사에 따른 자가 항체 농도 분포 연구

  • Kim, Jean-Soo (Dept. of Clinical Pathology, Gwangyang Health College)
  • 김진수 (광양보건대학교 임상병리과)
  • Received : 2013.06.11
  • Accepted : 2013.09.06
  • Published : 2013.09.30

Abstract

This study was investigated the correlation between thyroid fine needle aspiration biopsy and serological test's concentrations. I examined fifty patients who were diagnosed with thyroid cancer from June 2012 to December 2012 in Pathology of a certain university hospital. Healthy fifty people were selected as a control group. Thyroid function tests were used as variables. In conclusion, The thyroglobulin and autoantibody was showed positive correlations in cancer groups. also Thyroglobulin Ab was showed a little correlation. If we examine this study items, we will get help in early diagnosis.

이 연구는 갑상선 조직 검사에 따른 갑상선 암 진단 시 선행되는 혈청학적 검사와 연관성을 보고자 실시하였다. 대상은 2012년 6월부터 2012년 12월까지 모 대학병원 병리과에 의뢰 받은 조직 검체 중 갑상선암 판정 받은 실험군 50명과 정상으로 판정 받은 대조군 50명으로 하였으며 변수는 갑상선 기능검사와 자가 항체 검사항목을 이용하였다. 결과는 Thyroglobulin는 물론이고 Thyroglobulin Ab도 어느 정도 유의성이 있는 것으로 나타났으며 이는 실험군의 자가 항체 존재를 의심할 수 있었으며 Calcitonin검사 항목도 유의성은 낮지만 유의성이 있는 것으로 나타났다. 연구를 토대로 관련 있는 검사항목을 중점적으로 검사 한다면 갑상선 암 초기 진단에 도움이 되는 검사 결과를 얻을 수 있을 것이다.

Keywords

References

  1. Van Herle, A. J., Vassart, G. and Dumont, J. E. 1979. Control of thyroglobulin synthesis and secretion(second of two parts). N Engl J Med. 301 : 307 - 314. DOI: http://dx.doi.org/10.1056/NEJM197908093010605
  2. B.K Kim, M.S Lee, M.C. Lee "Clinical significance of serum Thyroglobulin value of thyroid cancer", Nuclear Medicine Molecular Imaging/17, 1983., 41-47, Society of Nuclear Medicine
  3. K.S Jung, "Usefulness of tea globulin measurement of fine needle cleaning solution for the diagnosis of lymph node metastasis over the nipple thyroid cancer patients", Kosin University College of Medicine Journals /24, 2009., 131-134, kosin university college of medcine
  4. Grant CS, Hay ID, Gough IR, Bergstralh EJ, Goellner JR, McConahey WM. Local recurrence in papillary thyoid carcinoma: is extent of surgical resection important? Surgery 104:954-962, 1988
  5. McDougall IR: Graves' disease: Current Concept MCNA 75:79-95,1991.
  6. S.K Joon, J.T. Lee, K.B Lee, "Stu요 of serum thyroglobulin value in autoimmune thyroid disease", Kyungpook University School of Medicine Journals/33, 1992., 261-273, Kyungpook National University School of Medicine
  7. hashimoto H: Zur Kentnis der lymphomatosen veranderung der shilddruse(Struma Lymphomatosa). Arch klin chir, 97:219-248, 1912
  8. H.K No, K.S Lee, K.Y Sung, "Significance of Direct Assay of Anti Mic Ab and Anti Tg Ab in thyroid disease", Chungnam University School of Medicine Journals/17, 1990., 267-272, Chungnam University School of Medicine Regional Medical Research Institute
  9. Rose NR, Witebsky E: Studies in organ-specificity V. changes
  10. Doniach D, Roitt IM: Autoimmunity in Hashimoto's disease and its implication. J clin Endocrinol metab, 77: 1293, 1957 DOI: http://dx.doi.org/10.1210/jcem-17-11-1293
  11. Aizawa T, Ishihara M, Koizumi Y, Hahizume K, Takasu N, Yamada T, Kobatashi I, Watanabe T, Shimizu Z: Serum thyroglobulin concentration ans an indicator for assessing thyroid stimulation in patients with Graves' sisease during antithyroid drug therapy.
  12. Chang Soon Koh, Mun Ho Lee, Seon Yang Park, In Sohn, Bo Youn Cho, Hwi Joong Yoon, "Study on serum Thyroglobulin value of thyroid various diseases", The Korean Journal of Internal Medicine/26, 1983., 219-227, The Korean Association of Internal Medicine
  13. Lo Gerfo, P, Li Volsi, and Colacchio, D.: Thyrogrobulin production by thyroid cncers J. Surg. Res., 24: 1, 1978 DOI: http://dx.doi.org/10.1016/0022-4804(78)90014-8
  14. Van Herle, A. J. and UILer, R.. P.: Elevated serum throgloulin : A marker of metastases in differentiated thyroid carcinomas. J. Clin. Invest., 56:272, 1975 DOI: http://dx.doi.org/10.1172/JCI108090
  15. Lewis, E., Braverman, Robert D. and Utiger.(2005). Werner & Ingbar's the thyroid. In Carcinoma of follicular epithelium: Surgical therapy(Robert, M, beazley). Lippincott Williams & Wilkins, 1 : 956 - 958.
  16. Van Herle, A. J., Uller, R. P., Matthews, N. I. and Brown, J. 1973. Radioimmunoassay for measurement of thyroglobulin in human serum. J Clin Invest. 52 : 1320- 1327. DOI: http://dx.doi.org/10.1172/JCI107303
  17. Whitley, R. J. and Ain, K. B. 2004. Thyroglobulin: a specific serum marker for the management of thyroid carcinoma. Clin Lab Med. 24 : 29 - 47. DOI: http://dx.doi.org/10.1016/j.cll.2004.01.001
  18. Baloch, Z., Carayon, P., Conte-Devolx, B., Demers, L. M., Feldt-Rasmussen, U., Henry, J. F., LiVosli, V. A., Niccoli-Sire, P., John, R., Ruf, J., Smyth, P. P., Spencer, C. A. and Stockigt, J. R. 2003. Guidelines Committee, National Academy of Clinical Biochemistry. Laboratory medicine practice guidelines. Laboratory support for the diagnosis and monitoring of thyroid disease. Thyroid. 13 : 3 - 126. DOI: http://dx.doi.org/10.1089/105072503321086962
  19. M.J Lee, "Clinicopathologic features in papillary thyroid carcinoma patients with chronic lymphocytic thyroiditis", 2013., master's degree, Inje University Graduate School
  20. H.W. Jang, "the factors of Clinical characteristics and survival rate in thyroid cancer ", 2008., master's degree, Sungkyunkwan University Graduate School.