Asian Pacific Journal of Cancer Prevention

  • 제14권8호
  • /
  • Pages.4549-4552
  • /
  • 2013
  • /
  • 1513-7368(pISSN)
  • /
  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
권호 표지
DOI QR코드

DOI QR Code

Lymphangiogenic and Angiogenic Microvessel Density in Chinese Patients with Gastric Carcinoma: Correlation with Clinicopathologic Parameters and Prognosis

  • Cao, Fang (Department of Surgery, the Affiliated Kunshan First People's Hospital, Jiangsu University) ;
  • Hu, Yong-Wei (Department of Surgery, the Affiliated Kunshan First People's Hospital, Jiangsu University) ;
  • Li, Ping (Department of Medical Oncology, Changzheng Hospital) ;
  • Liu, Ying (Department of Medical Oncology, Changzheng Hospital) ;
  • Wang, Kuo (Department of Surgery, the Affiliated Kunshan First People's Hospital, Jiangsu University) ;
  • Ma, Lei (Department of Surgery, the Affiliated Kunshan First People's Hospital, Jiangsu University) ;
  • Li, Peng-Fei (Department of Surgery, the Affiliated Kunshan First People's Hospital, Jiangsu University) ;
  • Ni, Can-Rong (Department of Pathology, Changhai Hospital) ;
  • Ding, Hou-Zhong (Department of Surgery, the Affiliated Kunshan First People's Hospital, Jiangsu University)
  • 발행 : 2013.08.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

The incidence of gastric cancer worldwide, and in particular in developing countries, has shown a marked increase. Poor prognosis of gastric cancer patients occurs due to the rapid metastasis of the disease via the lymphatic and blood vessels. The aim of this study was to investigate the expression and the clinical significance of D2-40 and CD34 in human gastric cancer. D2-40 and CD34 expression wasdetected in 1,072 cases of Chinese patients with gastric carcinoma using immunohistochemistry. The lymphatic vessel density (LVD) and microvessel density (MVD) were calculated and analyzed and the correlation with the clinicopathological factors and prognosis was determined. The LVD and MVD of the gastric cancer cases were significantly higher compared to those of normal tissues (P < 0.05). The expression of D2-40-LVD and CD34-MVD in the malignancies were positively related to the age, tumor size, invasion depth, lymphatic metastasis and pathological tumor-node-metastasis (pTNM) (P < 0.05); However, no statistically significant difference was identified between them with the patient gender (P > 0.05). Up-regulation of D2-40 and CD34 expression was significantly correlated with the poor survival rate in univariate and multivariate analyses. The LVD marked by D2-40 and the MVD marked by CD34 were positively correlated to the clinicopathological factors of the malignancies and may play important role in the development and progression of gastric cancer.

키워드

참고문헌

  1. Breiteneder-Geleff S, Soleiman A, Kowalski H, et al (1999). Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium. Am J Pathol, 154, 385-94. https://doi.org/10.1016/S0002-9440(10)65285-6
  2. Del Casar JM, Corte MD, Alvarez A, et al (2008). Lymphatic and/or bloodvessel invasion in gastric cancer: relationship with clinicopathological parameters, biological factors and prognostic significance. J Cancer Res Clin oncol, 134, 153-61. https://doi.org/10.1007/s00432-007-0264-3
  3. Du CY, Chen JG, Zhou Y, et al (2012). Impact of lymphatic and/or blood vessel invasion in stage II gastric cancer. World J Gastroenterol, 18, 3610-6. https://doi.org/10.3748/wjg.v18.i27.3610
  4. El-Gohary YM, Metwally G, Saad RS, et al (2008). Prognostic significance of intratumoral and peritumoral lymphatic density and blood vessel density in invasive breast carcinomas. Am J Clin Pathol, 129, 578-86. https://doi.org/10.1309/2HGNJ1GU57JMBJAQ
  5. Inal A, Kaplan Ma, Kucukoner M, et al (2012). Prognostic factors in first-line chemotherapy treated metastatic gastric cancer patients: a retrospective study. Asian Pac J Cancer Prev, 13, 3869-72. https://doi.org/10.7314/APJCP.2012.13.8.3869
  6. Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  7. Kaiserling E (2004). Immunohistochemieal identification of lymph vessels,with D2-40 in diagnostic pathology. Pathology, 25, 362-74.
  8. Kim JH, Park SS, Park SH, et al (2010). Clinical significance of immunohistochemically-identified lymphatic and/or blood vessel tumor invasion in gastric cancer. J Surg Res, 162, 177-83. https://doi.org/10.1016/j.jss.2009.07.015
  9. Marks A, Sutherland DR, Bailey D, et al (1999). Characterization and distribution of an oncofetal antigen (M2A antigen) expressed on testicular germ cell tumours. Br J Cancer, 80, 569-78. https://doi.org/10.1038/sj.bjc.6690393
  10. Milne AN, Carneiro F, O Morain C, Offerhaus GJ (2009). Nature meets nurture: Molecular genetics of gastric cancer. Hum Genet, 126, 615 28. https://doi.org/10.1007/s00439-009-0722-x
  11. Padera TP, Kadambi A, di Tomaso E, et al (2002). Lymphatic metastasis in the absence offunctional intratumor lymphatics. Science, 296, 1883-6. https://doi.org/10.1126/science.1071420
  12. Saad RS, Kordunsky L, Liu YL, et al (2006). Lymphatic microvessel density as prognostic marker in colorectal cancer. Mod Pathol, 19, 1317-23. https://doi.org/10.1038/modpathol.3800651
  13. Teo NB, Shoker BS, Jarvis C, et al (2003). Angiogenesis and invasive recurrence in ductal carcinoma in situ of the breast. Eur J Cancer, 39, 38-44. https://doi.org/10.1016/S0959-8049(02)00248-4
  14. Vieira SC, Silva BB, Pinto GA, et al (2005). CD34 as a marker for evaluating angiogenesis in cervical cancer. Pathol Res Pract, 201, 313-8. https://doi.org/10.1016/j.prp.2005.01.010
  15. Weidner N (1995). Current pathologic methods for measuring intratumoral micro vessel density within breast carcinoma and other soild tumors. Breast Cancer Res Treat, 36, 169-80. https://doi.org/10.1007/BF00666038
  16. Zhang SQ, Yu H, Zhang LL (2009). Clinical implications of increased lymph vessel density in the lymphatic metastasis of early-stage invasive cervical carcinoma: a clinical immunohistochemical method study. BMC Cancer, 9, 64. https://doi.org/10.1186/1471-2407-9-64

피인용 문헌

  1. Experimental Study on Residual Tumor Angiogenesis after Cryoablation vol.15, pp.6, 2014, https://doi.org/10.7314/APJCP.2014.15.6.2491
  2. Expression of Annexin A3 in Gastric Cancer and its Correlation with Proliferation and Apoptosis vol.15, pp.7, 2014, https://doi.org/10.7314/APJCP.2014.15.7.3001
  3. The different role of intratumoral and peritumoral lymphangiogenesis in gastric cancer progression and prognosis vol.15, pp.1, 2015, https://doi.org/10.1186/s12885-015-1501-9
  4. Microvessel Density as a Prognostic Factor in Ovarian Cancer: a Systematic Review and Meta-analysis vol.16, pp.3, 2015, https://doi.org/10.7314/APJCP.2015.16.3.869
  5. Prognostic value of microvessel density in cervical cancer vol.18, pp.1, 2018, https://doi.org/10.1186/s12935-018-0647-3
  6. The prognostic significance of lymphovascular invasion in patients with resectable gastric cancer: a large retrospective study from Southern China vol.15, pp.1, 2015, https://doi.org/10.1186/s12885-015-1370-2