The Korean Journal of Physiology and Pharmacology

  • 제17권5호
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  • Pages.405-409
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  • 2013
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  • 1226-4512(pISSN)
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  • 2093-3827(eISSN)
대한약리학회 (The Korean Society of Pharmacology)
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Sex Differences in Hippocampal Neuronal Sensitization by Nicotine in M. gerbils

  • Hur, Young-Na (Department of Pharmacology, Korea University College of Medicine) ;
  • Lee, Joon (Department of Pharmacology, Korea University College of Medicine) ;
  • Sohn, Seung-Chan (Department of Pharmacology, Korea University College of Medicine) ;
  • Won, Chung-Gil (Department of Anatomy, College of Veterinary Medicine, Gyeongsang National University) ;
  • Lee, Hyung-Ha (Department of Pharmacology, Korea University College of Medicine) ;
  • Kim, Dong-Hoon (Department of Pharmacology, Korea University College of Medicine) ;
  • Choi, Sang-Hyun (Department of Pharmacology, Korea University College of Medicine) ;
  • Shin, Kyung-Ho (Department of Pharmacology, Korea University College of Medicine) ;
  • Chun, Boe-Gwun (Department of Pharmacology, Korea University College of Medicine)
  • 투고 : 2013.05.02
  • 심사 : 2013.08.13
  • 발행 : 2013.10.30
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초록

We studied the sex different nicotine effect on evoked population spike amplitudes (ePSA) and connexin (Cx) expression in the hippocampus CA1 area of gerbils. Acute doses of nicotine bitartrate (0.5 mg/kg: NT-0.5) slightly reduced ePSA in males but markedly augmented that in females. Acute NT (5.0 mg/kg) markedly increased the ePSA in all gerbils. Unlike acute NT-0.5, repeated NT-0.5 injection (twice a day for 7 days) significantly increased the ePSA in males and slightly affected the NT-0.5 effect in females. The Cx36 and Cx43 expression levels as well as Cx expressing neuronal populations were significantly increased by repeated NT-0.5 in in both male and female gerbils, and particularly, Cx43 expression was somewhat prominent in females. These results demonstrated a sex difference with respect to the nicotine effect on hippocampal bisynaptic excitability, irrelevant to connexin expression.

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참고문헌

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