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Evaluation of Treatment Outcomes of Early-Stage Endometrial Cancer Radiotherapy: A Single Center Experience

  • Demiral, S. (Department of Radiation Oncology, Division of Epidemiology, Gulhane Military Medical Academy) ;
  • Beyzadeoglu, M. (Department of Radiation Oncology, Division of Epidemiology, Gulhane Military Medical Academy) ;
  • Sager, O. (Department of Radiation Oncology, Division of Epidemiology, Gulhane Military Medical Academy) ;
  • Dincoglan, F. (Department of Radiation Oncology, Division of Epidemiology, Gulhane Military Medical Academy) ;
  • Uysal, B. (Department of Radiation Oncology, Division of Epidemiology, Gulhane Military Medical Academy) ;
  • Gamsiz, H. (Department of Radiation Oncology, Division of Epidemiology, Gulhane Military Medical Academy) ;
  • Akin, M. (Department of Radiation Oncology, Division of Epidemiology, Gulhane Military Medical Academy) ;
  • Turker, T. (Department of Public Health, Division of Epidemiology, Gulhane Military Medical Academy) ;
  • Dirican, B. (Department of Radiation Oncology, Division of Epidemiology, Gulhane Military Medical Academy)
  • 발행 : 2014.12.18

초록

Background: Postoperative adjuvant radiotherapy (RT) in the management of early stage endometrial cancer (EC) is still controversial. Here we report our institutional experience with patients who received postoperative RT for stage I-II EC over a period of 35 years and assess potential predictors of local recurrence (LR), distant metastasis (DM), and overall survival (OS). Materials and Methods: A total of 188 patients undergoing postoperative RT for stage IA-II EC between 1977 and 2012 were evaluated. Some 96 received median 46 Gy whole pelvic radiotherapy (WPRT) (range: 40-60 Gy), 37 were given WPRT with vaginal cuff therapy (VCT), and 55 received only VCT either with brachytherapy (BT) or stereotactic body radiotherapy (SBRT). Chemotherapy was given to 5 patients with uterine papillary serous carcinoma (UPSC). Logistic regression analysis was used to assess the effect of clinicopathological factors on LR, DM, and OS. Results: Median follow-up time was 11 years (range: 1-35 years). At the time of analysis, 34 patients were not alive. Of the 15 patients with LR, 7 (46.7%) recurred in the vaginal stump, 5 (33.3%) in the pelvic region, and 3 (20%) in the paraaortic nodal region, while 12 had distant metastasis. UPSC histology (p=0.027), sole VCT (p=0.041), high histologic grade (p=0.034), and age ${\geq}71$ (p=0.04) were poor prognostic factors on univariate analysis. Conclusions: In our patients receiving radiotherapy for early-stage EC, grade III disease and age ${\geq}71$ were associated with shorter OS whereas UPSC histology was an independent predictor for both LR and DM.

키워드

참고문헌

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  3. A Retrospective Study of the Treatment Results & Patterns of Failure of Type II Endometrial Cancer Patients Treated at Radiotherapy Department, NCI, Cairo University during the Period from January 2000 till December 2012 vol.07, pp.08, 2016, https://doi.org/10.4236/jct.2016.78063