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Prognostic Value of PLCE1 Expression in Upper Gastrointestinal Cancer: a Systematic Review and Meta-analysis

  • Cui, Xiao-Bin (Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology) ;
  • Peng, Hao (Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology) ;
  • Li, Su (Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology) ;
  • Li, Ting-Ting (Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology) ;
  • Liu, Chun-Xia (Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine) ;
  • Zhang, Shu-Mao (Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology) ;
  • Jin, Ting-Ting (Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology) ;
  • Hu, Jian-Ming (Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology) ;
  • Jiang, Jin-Fang (Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology) ;
  • Liang, Wei-Hua (Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology) ;
  • Li, Na (Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology) ;
  • Li, Li (Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology) ;
  • Chen, Yun-Zhao (Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology) ;
  • Li, Feng (Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology)
  • 발행 : 2014.12.18

초록

Background: A number of studies have identified a shared susceptibility locus in phospholipase C epsilon 1 (PLCE1) for esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinomas (GCA). However, the results of PLCE1 expression in esophageal and gastric cancer remain inconsistent and controversial. Moreover, the effects on clinicopathological features remain undetermined. This study aimed to provide a precise quantification of the association between PLCE1 expression and the risk of ESCC and GCA through meta-analysis. Materials and Methods: Eligible studies were identified from PubMed, Wanfang Data, ISI Web of Science, and the Chinese National Knowledge Infrastructure databases. Using RevMan5.2 software, pooled odds ratios (ORs) with 95% confidence intervals (CIs) were employed to assess the association of PLCE1 expression with clinicopathological features relative to ESCC or GCA. Results: Seven articles were identified, including 761 esophageal and gastric cancer cases and 457 controls. Overall, we determined that PLCE1 expression was associated with tumor progression in both esophageal cancers (pooled OR=5.93; 95%CI=3.86 to 9.11) and gastric cancers (pooled OR=9.73; 95%CI=6.46 to 14.7). Moreover, invasion depth (pooled OR=3.62; 95%CI=2.30 to 5.70) and lymph node metastasis (pooled OR=4.21; 95%CI=2.69 to 6.59) were linked with PLCE1 expression in gastric cancer. However, no significant associations were determined between PLCE1 overexpression and the histologic grade, invasion depth, and lymph node metastasis in esophageal cancer. Conclusions: Our metaanalysis results indicated that upregulated PLCE1 is significantly associated with an increased risk of tumor progression in ESCC and GCA. Therefore, PLCE1 expression can be appropriately regarded as a promising biomarker for ESCC and GCA patients.

키워드

참고문헌

  1. Abnet CC, Freedman ND, Hu N, et al (2010). A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. Nature genetics, 42, 764-7. https://doi.org/10.1038/ng.649
  2. Baertschiger RM, Serre-Beinier V, Morel P, et al (2009). Fibrogenic potential of human multipotent mesenchymal stromal cells in injured liver. PloS one, 4, 6657. https://doi.org/10.1371/journal.pone.0006657
  3. Bai Y, Edamatsu H, Maeda S, et al (2004). Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development. Cancer Res, 64, 8808-10. https://doi.org/10.1158/0008-5472.CAN-04-3143
  4. Bergers G, Benjamin LE (2003). Tumorigenesis and the angiogenic switch. Nature Reviews Cancer, 3, 401-10. https://doi.org/10.1038/nrc1093
  5. Bourguignon LY, Gilad E, Brightman A, et al (2006). Hyaluronan-CD44 interaction with leukemia-associated RhoGEF and epidermal growth factor receptor promotes Rho/Ras co-activation, phospholipase C epsilon-Ca2+ signaling, and cytoskeleton modification in head and neck squamous cell carcinoma cells. J Biol Chem, 281, 14026-40. https://doi.org/10.1074/jbc.M507734200
  6. Bunney TD, Baxendale RW, Katan M (2009). Regulatory links between PLC enzymes and Ras superfamily GTPases: Signalling via PLCe. Adv Enzyme Regul, 49, 54-8. https://doi.org/10.1016/j.advenzreg.2009.01.004
  7. Bye H, Prescott NJ, Lewis CM, et al (2012). Distinct genetic association at the PLCE1 locus with oesophageal squamous cell carcinoma in the South African population. Carcinogenesis, 33, 2155-61. https://doi.org/10.1093/carcin/bgs262
  8. Wu C, Wang Z, Song X, et al (2011). Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. Nat Genet, 43, 79-84 https://doi.org/10.1038/ng.727
  9. Carmeliet P, Jain RK (2000). Angiogenesis in cancer and other diseases. Nature, 407, 249-57. https://doi.org/10.1038/35025220
  10. Chen YZ, Cui XB, Hu JM, et al (2013). Overexpression ofPLCE1in Kazakh esophageal squamous cell carcinoma: implications in cancer metastasis and aggressiveness. Apmis, 121, 908-18. https://doi.org/10.1111/apm.12095
  11. Cui XB, Chen YZ, Pang XL, et al (2013). Multiple polymorphisms within the PLCE1 are associated with esophageal cancer via promoting the gene expression in a Chinese Kazakh population. Gene, 530, 315-22. https://doi.org/10.1016/j.gene.2013.08.057
  12. Cui XB, Zhao ZM, Liu D, et al (2014a), Inactivation of miR- 34a by aberrant CpG methylation in Kazakh patients with esophageal carcinoma. J Exp Clin Canc Res, 33, 20. https://doi.org/10.1186/1756-9966-33-20
  13. Cui XB, Pang XL, Li S, et al (2014b). Elevated expression patterns and tight correlation of the PLCE1 and NF-${\kappa}B$ signaling in Kazakh patients with esophageal carcinoma. Medical Oncol, 31, 791 https://doi.org/10.1007/s12032-013-0791-5
  14. Danielsen SA, Cekaite L, Agesen TH, et al (2011). Phospholipase C isozymes are deregulated in colorectal cancer-insights gained from gene set enrichment analysis of the transcriptome. PloS one, 6, 24419. https://doi.org/10.1371/journal.pone.0024419
  15. Gonzalez-Garcia A, Pritchard CA, Paterson HF, et al (2005). RalGDS is required for tumor formation in a model of skin carcinogenesis. Cancer cell, 7, 219-26. https://doi.org/10.1016/j.ccr.2005.01.029
  16. Gu H, Ding G, Zhang W, et al (2012). Replication study of PLCE1 and C20orf54 polymorphism and risk of esophageal cancer in a Chinese population. Mol Biol Rep, 39, 9105-11. https://doi.org/10.1007/s11033-012-1782-x
  17. Hu H (2012). Roles of genetic polymorphism and mutation in esophageal squamous cell carcinoma (ESCC) and non-small cell lung cancer (NSCLC)[D]. CHINA: Fudan University, 28-41.
  18. Hu H, Yang J, Sun Y, et al (2012). Putatively functional PLCE1 variants and susceptibility to esophageal squamous cell carcinoma (ESCC): a case-control study in eastern Chinese populations. Ann Surg Oncol, 19, 2403-10. https://doi.org/10.1245/s10434-011-2160-y
  19. Islami F, Boffetta P, Ren J-S, et al (2009). High-temperature beverages and foods and esophageal cancer risk-A systematic review. Int J Cancer, 125, 491-524. https://doi.org/10.1002/ijc.24445
  20. Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  21. Li M, Edamatsu H, Kitazawa R, et al (2009). Phospholipase Cepsilon promotes intestinal tumorigenesis of Apc (Min/+) mice through augmentation of inflammation and angiogenesis. Carcinogenesis, 30, 1424-32. https://doi.org/10.1093/carcin/bgp125
  22. Liang Q (2012). Expression of PLCE1 in gastric cancer and its effect on cell cycle and apoptosis of gastric cancer cells. CHINA:Huazhong University of Science & Technology, 14-22.
  23. Luo D, Gao Y, Wang S, et al (2011). Genetic variation in PLCE1 is associated with gastric cancer survival in a Chinese population. J Gastroenterol, 46, 1260-6. https://doi.org/10.1007/s00535-011-0445-3
  24. Luo XP (2014). Phospholipase C epsilon-1 inhibits p53 expression in lung cancer. Cell Biochem Funct, 32, 294-8. https://doi.org/10.1002/cbf.3015
  25. Ma H, Wang LE, Liu Z, et al (2011). Association between novel PLCE1 variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck. BMC Cancer, 11, 258. https://doi.org/10.1186/1471-2407-11-258
  26. Malik MA, Umar M, Gupta U, et al (2014). Phospholipase C epsilon 1 (PLCE1 rs2274223A>G, rs3765524C>T and rs7922612C>T) polymorphisms and esophageal cancer risk in the Kashmir valley. Asian Pac J Cancer Prev, 15, 4319-23. https://doi.org/10.7314/APJCP.2014.15.10.4319
  27. Mbulaiteye SM, Hisada M, El-Omar EM (2009). Helicobacter pylori associated global gastric cancer burden. Frontiers in Bioscience: a J Virtual Library, 14, 1490.
  28. Ou L, Guo Y, Luo C, et al (2010). RNA interference suppressing PLCE1 gene expression decreases invasive power of human bladder cancer T24 cell line. Cancer genetics and cytogenetics, 200, 110-9. https://doi.org/10.1016/j.cancergencyto.2010.01.021
  29. Ren J (2011). Family history and genetic susceptibility to gastric cardia adenocarcinoma of Chinese Han population. CHINA:Zhengzhou University, 43-7.
  30. Rhee SG (2001). Regulation of phosphoinositide-specific phospholipase $C^*$. Ann Review Biochemistry, 70, 281-312. https://doi.org/10.1146/annurev.biochem.70.1.281
  31. Song C, Hu CD, Masago M, et al (2001). Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras. J Biol Chem, 276, 2752-7. https://doi.org/10.1074/jbc.M008324200
  32. Tran GD, Sun XD, Abnet CC, et al (2005). Prospective study of risk factors for esophageal and gastric cancers in the Linxian general population trial cohort in China. Int J Cancer, 113, 456-63. https://doi.org/10.1002/ijc.20616
  33. Wang L-D, Zhou F-Y, Li X-M, et al (2010). Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. Nature Genetics, 42, 759-63. https://doi.org/10.1038/ng.648
  34. Wang M, Zhang R, He J, et al (2012). Potentially functional variants of PLCE1 identified by GWASs contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population. PLoS One, 7, 31932. https://doi.org/10.1371/journal.pone.0031932
  35. Wang X, Zbou C, Qiu G, et al (2007). Screening of new tumor suppressor genes in sporadic colorectal cancer patients. Hepato-gastroenterol, 55, 2039-44.
  36. Wang X, Zhou C, Qiu G, et al (2011). Phospholipase C epsilon plays a suppressive role in incidence of colorectal cancer. Medical Oncology, 29, 1051-8.
  37. Wing MR, Bourdon DM, Harden TK (2003). PLC-epsilon: a shared effector protein in Ras-, Rho-, and G alpha beta gamma-mediated signaling. Molecular Interventions, 3, 273-80. https://doi.org/10.1124/mi.3.5.273
  38. Wu L (2011). The expression and significance of PLCE1 in gastric cancer.[D]. CHINA:Huazhong University of Science and Technology, 11-23.
  39. Wu M, Liu AM, Kampman E, et al (2009). Green tea drinking, high tea temperature and esophageal cancer in high-and lowrisk areas of Jiangsu Province, China: A population-based case-control study. Int J Cancer, 124, 1907-13. https://doi.org/10.1002/ijc.24142
  40. Yu S, Wu F, Guo K, et al (2014). Expression of phospholipase C epsilon-1 in gastric cancer and its association with prognosis. Zhonghua Wei Chang Wai Ke Za Zhi, 17, 378-82.
  41. Zhang W, Su L, Jun-hui C, et al (2012). Expression of phospholipase C epsilon-1 in locations of different parts gastric cancers. henan medical research, 21, 399-402.
  42. Zhao L, Wei Z-B, Yang C-Q, et al (2014). Effects of PLCE1 gene silencing by RNA interference on cell cycling and apoptosis in esophageal carcinoma cells. Asian Pac J Cancer Prev, 15, 5437-42. https://doi.org/10.7314/APJCP.2014.15.13.5437
  43. Zhao X, Zhou F, Zhang L, et al (2012). Expression of PLCE1 protein in esophageal multistage carcinogenesis. J Henan University:Med Sci, 31, 203-5.
  44. Zhu J, Yin L, Hou L, et al (2012). Expression characteristics and significance of PLCE1 in esophageal squamous cell carcinoma of xinjiang kazakh. J Nongken Med, 5-8.

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