DOI QR코드

DOI QR Code

Association of Urinary Cesium with Breast Cancer Risk

  • Qin, Ya-Chao (School of Public Health, Sun Yat-Sen University) ;
  • Tang, Lu-Ying (The Third Affiliated Hospital, Sun Yat-Sen University) ;
  • Su, Yi (School of Public Health, Sun Yat-Sen University) ;
  • Chen, Li-Juan (School of Public Health, Sun Yat-Sen University) ;
  • Su, Feng-Xi (The Second Affiliated Hospital, Sun Yat-Sen University) ;
  • Lin, Ying (The First Affiliated Hospital, Sun Yat-Sen University) ;
  • Zhang, Ai-Hua (Guangdong Prevention and Treatment Center for Occupational Diseases) ;
  • Ren, Ze-Fang (School of Public Health, Sun Yat-Sen University)
  • 발행 : 2014.12.18

초록

Background: The aim of this study is to examine the association of urinary cesium with breast cancer risk. Materials and Methods: We collected survey data and urine specimens from 240 women with incident invasive breast cancer before their treatment and 246 age-matched female controls between October 2009 and July 2010. Urinary concentrations of cesium were determined by inductively coupled plasma mass spectrometry. Interviews were conducted by face-to-face to obtain information on potential breast cancer risk factors. Logistic regression analysis was used to estimate the associations. Results: Creatinine-adjusted levels [median ($25^{th}$, $75^{th}$) ug/g] of cesium in cases and controls were 17.6 (13.1, 24.0) and 19.3 (15.3, 25.7), respectively. After adjustment for potential risk factors, women in the second and highest tertile of cesium showed a decreased risk of breast cancer in a dose-dependent manner as compared with those in the lowest tertile [ORs and 95% CIs: 0.75 (0.46-1.22) and 0.50 (0.30-0.82), respectively]. This decrease was more evident in women with ER positive or localized clinical stage in an exploratory stratification analysis. Conclusions: These findings suggest that cesium may have anticancer efficacy and urinary cesium has potential as a biomarker for breast cancer risk assessment.

키워드

참고문헌

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