DOI QR코드

DOI QR Code

Genetic Epidemiological Analysis of Esophageal Cancer in High-incidence Areas of China

  • Wang, Kai-Juan (Department of Epidemiology, College of Public Health, Zhengzhou University) ;
  • Yang, Jun-Xia (Department of Epidemiology, College of Public Health, Zhengzhou University) ;
  • Shi, Jia-Chen (Department of Epidemiology, College of Public Health, Zhengzhou University) ;
  • Deng, Song-Yuan (Henan Key Laboratory of Tumor Epidemiology) ;
  • Cao, Xiao-Qin (Department of Epidemiology, College of Public Health, Zhengzhou University) ;
  • Song, Chun-Hua (Department of Epidemiology, College of Public Health, Zhengzhou University) ;
  • Wang, Peng (Department of Epidemiology, College of Public Health, Zhengzhou University)
  • 발행 : 2014.12.18

초록

Genetic epidemiological studies have shown that genetic susceptibility to esophageal cancer (EC) is an important cause of its high incidence within families in some areas of China. The purpose of this study was to obtain evidence of a genetic basis of EC in Xin-an and Xin-xiang counties in China. Familial aggregation and complex segregation analyses were performed of 79 EC families in these counties. The heritability of EC was examined using Falconer's method and complex segregation analysis was conducted with the SEGREG program in Statistical Analysis for Genetic Epidemiology (SAGE version 5.3.1). The results showed that the distribution of EC in families did not fit well into a binomial distribution. The heritability of EC among first-degree and second-degree relatives was $67.0{\pm}7.31%$ and $43.1%{\pm}9.80%$, respectively, and the summing up powered heritability was $53.2{\pm}6.74%$. The segregation ratio was 0.045. Complex segregation analysis showed that the genetic model of EC was additive. The current results provide evidence for an inherited propensity to EC in certain high-risk groups in China, and support efforts to identify the genes that confer susceptibility to this disease.

키워드

참고문헌

  1. Carter CL, Hu N, Wu M, et al (1992). Segregation analysis of esophageal cancer in 221 high-risk Chinese families. J Natl Cancer Inst, 84, 771-6. https://doi.org/10.1093/jnci/84.10.771
  2. Chen W, He Y, Zheng R, et al (2013). Esophageal cancer incidence and mortality in China, 2009. J Thorac Dis, 5, 19-26.
  3. Dawsey SM, Fagundes RB, Jacobson BC, et al (2014). Diet and esophageal disease. Ann N Y Acad Sci, 1325, 127-37. https://doi.org/10.1111/nyas.12528
  4. Demeester SR (2009). Epidemiology and biology of esophageal cancer. Gastrointest Cancer Res, 3, 2-5.
  5. Dong LM, Potter JD, White E, et al (2008). Genetic susceptibility to cancer: the role of polymorphisms in candidate genes. JAMA, 299, 2423-36. https://doi.org/10.1001/jama.299.20.2423
  6. Douglas S. Falconer 1981. Introduction to Quantitative Genetics . Longman Press.
  7. Engel LS, Chow WH, Vaughan TL, et al (2003). Population attributable risks of esophageal and gastric cancers. J Natl Cancer Inst, 95, 1404-13. https://doi.org/10.1093/jnci/djg047
  8. Feng XS, Yang YT, Gao SG, et al (2014). Prevalence and age, gender and geographical area distribution of esophageal squamous cell carcinomas in North China from 1985 to 2006. Asian Pac J Cancer Prev, 15, 1981-7. https://doi.org/10.7314/APJCP.2014.15.5.1981
  9. Guohong Z, Min S, Duenmei W, et al (2010). Genetic heterogeneity of oesophageal cancer in high-incidence areas of southern and northern China. PLoS One, 5, 9668. https://doi.org/10.1371/journal.pone.0009668
  10. Hanna GL, Fingerlin TE, Himle JA, et al (2005). Complex segregation analysis of obsessive-compulsive disorder in families with pediatric probands. Hum Hered, 60, 1-9. https://doi.org/10.1159/000087135
  11. Hu N, Dawsey SM, Wu M, et al (1992). Familial aggregation of oesophageal cancer in Yangcheng County, Shanxi Province, China. Int J Epidemiol, 21, 877-82. https://doi.org/10.1093/ije/21.5.877
  12. Kollarova H, Machova L, Horakova D, et al (2007). Epidemiology of esophageal cancer--an overview article. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 151, 17-20. https://doi.org/10.5507/bp.2007.003
  13. Layke JC, Lopez PP (2006). Esophageal cancer: a review and update. Am Fam Physician, 73, 2187-94.
  14. Lee JH, Barral S, Cheng R, et al (2008). Age-at-onset linkage analysis in Caribbean Hispanics with familial late-onset Alzheimer's disease. Neurogenetics, 9, 51-60. https://doi.org/10.1007/s10048-007-0103-3
  15. Li CC, Mantel N (1968). A simple method of estimating the segregation ratio under complete ascertainment. Am J Hum Genet, 20, 61-81.
  16. Kanamori, M Schnell AH, Inoue M, et al (2001). Segregation analysis of gastric cancer in a Japanese population. Int J Hum Genet, 1, 263-70.
  17. Olopade OI, Pichert G (2001). Cancer genetics in oncology practice. Ann Oncol, 12, 895-908. https://doi.org/10.1023/A:1011176107455
  18. Pennathur A, Gibson MK, Jobe BA, et al (2013). Oesophageal carcinoma. Lancet, 381, 400-12. https://doi.org/10.1016/S0140-6736(12)60643-6
  19. Qiao YL, Hou J, Yang L, et al (2001). [The trends and preventive strategies of esophageal cancer in high-risk areas of Taihang Mountains, China]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 23, 10-4.
  20. Stricker C, Fernando RL, Elston RC (1995). Linkage analysis with an alternative formulation for the mixed model of inheritance: the finite polygenic mixed model. Genetics, 141, 1651-6.
  21. Sun X, Chen W, Chen Z, et al (2010a). Population-based casecontrol study on risk factors for esophageal cancer in five high-risk areas in China. Asian Pac J Cancer Prev, 11, 1631-6.
  22. Sun X, Elston R, Barnholtz-Sloan J, et al (2010b). A segregation analysis of Barrett's esophagus and associated adenocarcinomas. Cancer Epidemiol Biomarkers Prev, 19, 666-74. https://doi.org/10.1158/1055-9965.EPI-09-1136
  23. Tang WR, Fang JY, Wu KS, et al (2014). Epidemiological characteristics and prediction of esophageal cancer mortality in China from 1991 to 2012. Asian Pac J Cancer Prev, 15, 6929-34. https://doi.org/10.7314/APJCP.2014.15.16.6929
  24. Tarone R E (1979). Testing the goodness of fit of the binomial distribution. Biometrika, 66, 585-90. https://doi.org/10.1093/biomet/66.3.585
  25. Tran GD, Sun XD, Abnet CC, et al (2005). Prospective study of risk factors for esophageal and gastric cancers in the Linxian general population trial cohort in China. Int J Cancer, 113, 456-63. https://doi.org/10.1002/ijc.20616
  26. Wang AH, Liu Y, Wang B, et al (2014). Epidemiological studies of esophageal cancer in the era of genome-wide association studies. World J Gastrointest Pathophysiol, 5, 335-43.
  27. Wu M, Zhang ZF, Kampman E, et al (2011). Does family history of cancer modify the effects of lifestyle risk factors on esophageal cancer? A population-based case-control study in China. Int J Cancer, 128, 2147-57. https://doi.org/10.1002/ijc.25532
  28. Zhang W, Bailey-Wilson JE, Li W, et al (2000). Segregation analysis of esophageal cancer in a moderately high-incidence area of northern China. Am J Hum Genet, 67, 110-9. https://doi.org/10.1086/302970

피인용 문헌

  1. Candidate susceptibility variants for esophageal squamous cell carcinoma vol.56, pp.6, 2017, https://doi.org/10.1002/gcc.22448
  2. Plasma Riboflavin Level is Associated with Risk, Relapse, and Survival of Esophageal Squamous Cell Carcinoma vol.69, pp.1, 2017, https://doi.org/10.1080/01635581.2017.1247890