Asian Pacific Journal of Cancer Prevention

  • 제15권22호
  • /
  • Pages.9949-9953
  • /
  • 2014
  • /
  • 1513-7368(pISSN)
  • /
  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Long-Term Treatment Results in Soft Tissue Sarcomas of the Thoracic Wall Treated with Pre-or-Postoperative Radiotherapy - a Single Institution Experience

  • Oksuz, Didem Colpan (Department of Radiation Oncology, Istanbul University Cerrahpasa Medical Faculty) ;
  • Ozdemir, Sevim (Department of Radiation Oncology, Istanbul University Cerrahpasa Medical Faculty) ;
  • Kaydihan, Nuri (Department of Radiation Oncology, Istanbul University Cerrahpasa Medical Faculty) ;
  • Dervisoglu, Sergulen (Department of Pathology, Istanbul University Cerrahpasa Medical Faculty) ;
  • Hiz, Murat (Department of Orthopedic Surgery, Istanbul University Cerrahpasa Medical Faculty) ;
  • Tuzun, Hasan (Department of Cardiovascular Surgery, Istanbul University Cerrahpasa Medical Faculty) ;
  • Mandel, Nil Molinas (Department of Medical Oncology, Istanbul University, Cerrahpasa Medical Faculty) ;
  • Koca, Sedat (Department of Radiation Oncology, Istanbul University Cerrahpasa Medical Faculty) ;
  • Dincbas, Fazilet Oner (Department of Radiation Oncology, Istanbul University Cerrahpasa Medical Faculty)
  • 발행 : 2014.12.18
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초록

Objective: To evaluate the long term results among patients with soft tissue sarcoma of the thoracic wall. Materials and Methods: Twenty-six patients who were treated with pre-or postoperative radiotherapy between December 1980-December 2007, with a diagnosis of soft tissue sarcoma of the thoracic wall were retrospectively evaluated. Results: The median age was 44 years (14-85 years) and 15 of them were male. A total of 50% of patients were grade 3. The most common histologic type of tumor was undifferentiated pleomorphic sarcoma (26.9%). Tumor size varied between 2-25 cm (median 6.5 cm). Seventeen of the cases had marginal and 9 had wide local resection. Four cases received preoperative radiotherapy and 22 postoperative radiotherapy. Six of the patients with large and high grade tumors received chemotherapy. Median follow-up time was 82 months (9-309 months). Local recurrence and metastasis was detected in 34.6% and 42.3% of patients, respectively. Five-year local control (LC), disease-free survival (DFS), overall survival (OS), and disease-specific survival (DSS) were 62%, 38%, 69%, and 76% respectively. On univariate analysis, the patients with positive surgical margins had a markedly lower 5-year LC rate than patients with negative surgical margin, but the difference was not significant (43% vs 78%, p=0.1). Five-year DFS (66% vs 17%) and DSS (92% vs 60%) rates were significantly worse for the patients who had high grade tumors (p=0.01, p=0.008 respectively). Conclusions: Tumor grade and surgical margin are essential parameters for determining the prognosis of thoracic wall soft tissue sarcoma both in our series and the literature.

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피인용 문헌

  1. Radiation-Induced Sarcoma following Prolonged Coronary Stent Placement vol.2018, pp.2090-6919, 2018, https://doi.org/10.1155/2018/2903801