The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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Regular Exercise Training Increases the Number of Endothelial Progenitor Cells and Decreases Homocysteine Levels in Healthy Peripheral Blood

  • Choi, Jeong Kyu (Department of Physiology, School of Medicine, Medical Research Institute, Pusan National University) ;
  • Moon, Ki Myung (Department of Surgery, Pusan National University Yangsan Hospital) ;
  • Jung, Seok Yun (Department of Physiology, School of Medicine, Medical Research Institute, Pusan National University) ;
  • Kim, Ji Yong (Department of Physiology, School of Medicine, Medical Research Institute, Pusan National University) ;
  • Choi, Sung Hyun (Department of Physiology, School of Medicine, Medical Research Institute, Pusan National University) ;
  • Kim, Da Yeon (Department of Physiology, School of Medicine, Medical Research Institute, Pusan National University) ;
  • Kang, Songhwa (Department of Physiology, School of Medicine, Medical Research Institute, Pusan National University) ;
  • Chu, Chong Woo (Department of Surgery, Pusan National University Yangsan Hospital) ;
  • Kwon, Sang Mo (Department of Physiology, School of Medicine, Medical Research Institute, Pusan National University)
  • Received : 2014.01.15
  • Accepted : 2014.02.19
  • Published : 2014.04.30
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Abstract

Endothelial progenitor cells (EPCs) are known to play an important role in the repair of damaged blood vessels. We used an endothelial progenitor cell colony-forming assay (EPC-CFA) to determine whether EPC numbers could be increased in healthy individuals through regular exercise training. The number of functional EPCs obtained from human peripheral blood-derived AC133 stem cells was measured after a 28-day regular exercise training program. The number of total endothelial progenitor cell colony-forming units (EPC-CFU) was significantly increased compared to that in the control group (p=0.02, n=5). In addition, we observed a significant decrease in homocysteine levels followed by an increase in the number of EPC-CFUs (p=0.04, n=5), indicating that the 28-day regular exercise training could increase the number of EPC colonies and decrease homocysteine levels. Moreover, an inverse correlation was observed between small-endothelial progenitor cell colony-forming units (small-EPC-CFUs) and plasma homocysteine levels in healthy men (r=-0.8125, p=0.047). We found that regular exercise training could increase the number of EPC-CFUs and decrease homocysteine levels, thus decreasing the cardiovascular disease risk in men.

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References

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