Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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A Genetic Variant in MiR-146a Modifies Digestive System Cancer Risk: a Meta-analysis

  • Li, Ying-Jun (Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health) ;
  • Zhang, Zhen-Yu (Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health) ;
  • Mao, Ying-Ying (Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health) ;
  • Jin, Ming-Juan (Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health) ;
  • Jing, Fang-Yuan (Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health) ;
  • Ye, Zhen-Hua (Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health) ;
  • Chen, Kun (Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health)
  • Published : 2014.01.15
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Abstract

MicroRNAs (miRNAs) negatively regulate gene expression and act as tumor suppressors or oncogenes in oncogenesis. The association between a single nucleotide polymorphism (SNP) in miR-146a rs2910164 and susceptibility to digestive system cancers was inconsistent in previous studies. In this study, we conducted a literature search of PubMed to identify all relevant studies published before August 31, 2013. A total of 21 independent case-control studies were included in this updated meta-analysis with 9,558 cases and 10,614 controls. We found that the miR-146a rs2910164 polymorphism was significantly associated with decreased risk of digestive system cancers in an allele model (OR=0.90, 95%CI 0.87-0.94), homozygote model (OR=0.84, 95%CI 0.77-0.91), dominant model (OR=0.90, 95%CI 0.84-0.96), and recessive model (OR=0.85, 95%CI 0.79-0.91), while in a heterozygous model (OR = 0.99, 95% CI 0.89-1.11) the association showed marginal significance. Subgroup analysis by cancer site revealed decreased risk in colorectal cancer above allele model (OR=0.90, 95%CI 0.83-0.97) and homozygote model (OR=0.85, 95%CI 0.72-1.00). Similarly, decreased cancer risk was observed when compared with allele model (OR=0.87, 95%CI 0.81-0.93) and recessive model (OR=0.81, 95%CI 0.72-0.90) in gastric cancer. When stratified by ethnicity, genotyping methods and quality score, decreased cancer risks were also observed. This current meta-analysis indicated that miR-146a rs2910164 polymorphism may decrease the susceptibility to digestive system cancers, especially in Asian populations.

Keywords

References

  1. Ahn DH, Rah H, Choi Y-K, et al (2012). Association of the miR-146aC>G, miR-149T>C, miR-196a2T>C, and miR-499A>G polymorphisms with gastric cancer risk and survival in the Korean population. Mol Carcinogen, 52, 39-51.
  2. Ambros V (2004). The functions of animal microRNAs. Nature, 431, 350-5. https://doi.org/10.1038/nature02871
  3. Brennecke J, Hipfner DR, Stark A, et al (2003). Bantam encodes a developmentally regulated microRNA that controls cell poliferation and regulates the proapoptotic gene hid in Drosophila. Cell, 113, 25-36. https://doi.org/10.1016/S0092-8674(03)00231-9
  4. Chu Y-H, Tzeng S-L, Lin C-W, et al (2012). Impacts of microRNA gene polymorphisms on the susceptibility of environmental factors leading to carcinogenesis in oral cancer. PLoS One, 7, e39777. https://doi.org/10.1371/journal.pone.0039777
  5. Dick DM (2011). Gene-environment interaction in psychological traits and disorders. Annu Rev Clin Psycho, 7, 383. https://doi.org/10.1146/annurev-clinpsy-032210-104518
  6. Gao L-B, Pan X-M, Sun H, et al (2010). The association between ATM D1853N polymorphism and breast cancer susceptibility: a meta-analysis. J Exp Clin Cancer Res, 29, 117. https://doi.org/10.1186/1756-9966-29-117
  7. Guo H, Wang K, Xiong G, et al (2010). A functional varient in microRNA-146a is associated with risk of esophageal squamous cell carcinoma in Chinese Han. Fam Cancer, 9, 599-603. https://doi.org/10.1007/s10689-010-9370-5
  8. Hezova R, Kovarikova A, Bienertova-Vasku J, et al (2012). Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer. World J Gastroenterol, 18, 2827-31. https://doi.org/10.3748/wjg.v18.i22.2827
  9. Jazdzewski K, Murray EL, Franssila K, et al (2008). Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma. P Natl A Sci, 105, 7269-74. https://doi.org/10.1073/pnas.0802682105
  10. Kim WH, Min KT, Jeon YJ, et al (2012). Association study of microRNA polymorphisms with hepatocellular carcinoma in Korean population. Gene, 504, 92-7. https://doi.org/10.1016/j.gene.2012.05.014
  11. Kwak PB, Iwasaki S, Tomari Y (2010). The microRNA pathway and cancer. Cancer Sci, 101, 2309-15. https://doi.org/10.1111/j.1349-7006.2010.01683.x
  12. Landi D, Gemignani F, Landi S (2012). Role of variations within microRNA-binding sites in cancer. Mutagenesis, 27, 205-10. https://doi.org/10.1093/mutage/ger055
  13. Lau J, Ioannidis JP, Schmid CH (1997). Quantitative synthesis in systematic reviews. Ann Intern Med, 127, 820-6. https://doi.org/10.7326/0003-4819-127-9-199711010-00008
  14. Lu LF, Boldin MP, Chaudhry A, et al (2010). Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell, 142, 914-29. https://doi.org/10.1016/j.cell.2010.08.012
  15. Lv M, Dong W, Li L, et al (2013). Association between genetic variants in pre-miRNA and colorectal cancer risk in a Chinese population. J Cancer Res Clin Oncol, 139, 1405-10. https://doi.org/10.1007/s00432-013-1456-7
  16. Ma L, Zhu L, Gu D, et al (2013). A genetic variant in miR-146a modifies colorectal cancer susceptibility in a Chinese population. Arch Toxicol, 87, 825-33. https://doi.org/10.1007/s00204-012-1004-2
  17. Mihalache F, Hoblinger A, Acalovschi M, et al (2012). A common variant in the precursor miR-146a sequence does not predispose to cholangiocarcinoma in a large European cohort. Hbpd Int, 11, 412-7.
  18. Okubo M, Tahara T, Shibata T, et al (2010). Association between common genetic variants in pre-microRNAs and gastric cancer risk in Japanese population. Helicobacter, 15, 524-31. https://doi.org/10.1111/j.1523-5378.2010.00806.x
  19. Paik JH, Jang J-Y, Jeon YK, et al (2011). MicroRNA-146a downregulates NF${\kappa}$B activity via targeting TRAF6 and functions as a tumor suppressor having strong prognostic implications in NK/T cell lymphoma. Clin Cancer Res, 17, 4761-71. https://doi.org/10.1158/1078-0432.CCR-11-0494
  20. Pavlakis E, Papaconstantinou I, Gazouli M, et al (2013). MicroRNA gene polymorphisms in pancreatic cancer. Pancreatology, 13, 273-8. https://doi.org/10.1016/j.pan.2013.02.005
  21. Peters JL, Sutton AJ, Jones DR, et al (2006). Comparison of two methods to detect publication bias in meta-analysis. JAMA, 295, 676-80. https://doi.org/10.1001/jama.295.6.676
  22. Qu KZ, Zhang K, Li H, et al (2011). Circulating microRNAs as biomarkers for hepatocellular carcinoma. J Clin Gastroenterol, 45, 355-60. https://doi.org/10.1097/MCG.0b013e3181f18ac2
  23. Ruan K, Fang X, Ouyang G (2009). MicroRNAs: novel regulators in the hallmarks of human cancer. Cancer Lett, 285, 116-26. https://doi.org/10.1016/j.canlet.2009.04.031
  24. Saunders MA, Liang H, Li W-H (2007). Human polymorphism at microRNAs and microRNA target sites. P Natl A Sci, 104, 3300-5. https://doi.org/10.1073/pnas.0611347104
  25. Shastry BS (2009). SNPs: impact on gene function and phenotype. In Single Nucleotide Polymorphisms, Humana Press, 3-22.
  26. Shen J, Ambrosone CB, DiCioccio RA, et al (2008). A functional polymorphism in the miR-146a gene and age of familial breast/ovarian cancer diagnosis. Carcinogenesis, 29, 1963-6. https://doi.org/10.1093/carcin/bgn172
  27. Srivastava K, Srivastava A, Mittal B (2010). Common genetic variants in pre-microRNAs and risk of gallbladder cancer in North Indian population. J Hum Genet, 55, 495-9. https://doi.org/10.1038/jhg.2010.54
  28. Tapia T, Sanchez A, Vallejos M, et al (2008). ATM allelic variants associated to hereditary breast cancer in 94 Chilean women: susceptibility or ethnic influences? Breast Cancer Res Tr, 107, 281-8. https://doi.org/10.1007/s10549-007-9544-5
  29. Thakkinstian A, McElduff P, D'Este C, et al (2005). A method for meta-analysis of molecular association studies. Stat Med, 24, 1291-306. https://doi.org/10.1002/sim.2010
  30. Wallace TA, Martin DN, Ambs S (2011). Interactions among genes, tumor biology and the environment in cancer health disparities: examining the evidence on a national and global scale. Carcinogenesis, 32, 1107-21. https://doi.org/10.1093/carcin/bgr066
  31. Wei J, Zheng L, Liu S, et al (2013). MiR-196a2 rs11614913 T > C polymorphism and risk of esophageal cancer in a Chinese population. Hum Immunol, 74, 1199-205. https://doi.org/10.1016/j.humimm.2013.06.012
  32. Wu D, Wang F, Dai WQ, et al (2013). The miR-146a rs2910164 G> C polymorphism and susceptibility to digestive cancer in Chinese. Asian Pac J Cancer P, 14, 399-403. https://doi.org/10.7314/APJCP.2013.14.1.399
  33. Xu Y, Li L, Xiang X, et al (2013). Three common functional polymorphisms in microRNA encoding genes in the susceptibility to hepatocellular carcinoma: A systematic review and meta-analysis. Gene, 527, 584-93. https://doi.org/10.1016/j.gene.2013.05.085
  34. Yin Z, Yan L, Cui Z, et al (2013). Effects of common polymorphisms rs2910164 in miR-146a and rs3746444 in miR-499 on cancer susceptibility: a meta-analysis. Mol Biol Rep, 1-11.
  35. Zeng Y, Sun QM, Liu NN, et al (2010). Correlation between pre-miR-146a C/G polymorphism and gastric cancer risk in Chinese population. World J Gastroenterol, 16, 3578-83. https://doi.org/10.3748/wjg.v16.i28.3578
  36. Zhou F, Zhu H, Luo D, et al (2012). A functional polymorphism in Pre-miR-146a is associated with susceptibility to gastric cancer in a Chinese population. DNA Cell Biol, 31, 1290-5. https://doi.org/10.1089/dna.2011.1596

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