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A Genetic Variant in MiR-146a Modifies Digestive System Cancer Risk: a Meta-analysis

  • Li, Ying-Jun (Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health) ;
  • Zhang, Zhen-Yu (Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health) ;
  • Mao, Ying-Ying (Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health) ;
  • Jin, Ming-Juan (Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health) ;
  • Jing, Fang-Yuan (Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health) ;
  • Ye, Zhen-Hua (Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health) ;
  • Chen, Kun (Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health)
  • 발행 : 2014.01.15

초록

MicroRNAs (miRNAs) negatively regulate gene expression and act as tumor suppressors or oncogenes in oncogenesis. The association between a single nucleotide polymorphism (SNP) in miR-146a rs2910164 and susceptibility to digestive system cancers was inconsistent in previous studies. In this study, we conducted a literature search of PubMed to identify all relevant studies published before August 31, 2013. A total of 21 independent case-control studies were included in this updated meta-analysis with 9,558 cases and 10,614 controls. We found that the miR-146a rs2910164 polymorphism was significantly associated with decreased risk of digestive system cancers in an allele model (OR=0.90, 95%CI 0.87-0.94), homozygote model (OR=0.84, 95%CI 0.77-0.91), dominant model (OR=0.90, 95%CI 0.84-0.96), and recessive model (OR=0.85, 95%CI 0.79-0.91), while in a heterozygous model (OR = 0.99, 95% CI 0.89-1.11) the association showed marginal significance. Subgroup analysis by cancer site revealed decreased risk in colorectal cancer above allele model (OR=0.90, 95%CI 0.83-0.97) and homozygote model (OR=0.85, 95%CI 0.72-1.00). Similarly, decreased cancer risk was observed when compared with allele model (OR=0.87, 95%CI 0.81-0.93) and recessive model (OR=0.81, 95%CI 0.72-0.90) in gastric cancer. When stratified by ethnicity, genotyping methods and quality score, decreased cancer risks were also observed. This current meta-analysis indicated that miR-146a rs2910164 polymorphism may decrease the susceptibility to digestive system cancers, especially in Asian populations.

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참고문헌

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  7. Effects of Two Common Polymorphisms rs2910164 in miR-146a and rs11614913 in miR-196a2 on Gastric Cancer Susceptibility vol.2015, pp.1687-630X, 2015, https://doi.org/10.1155/2015/764163
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  9. Quercetin inhibits proliferation and invasion acts by up-regulating miR-146a in human breast cancer cells vol.402, pp.1-2, 2015, https://doi.org/10.1007/s11010-014-2317-7
  10. Associations of Polymorphisms in mir-196a2, mir-146a and mir-149 with Colorectal Cancer Risk: A Meta-Analysis vol.22, pp.2, 2016, https://doi.org/10.1007/s12253-014-9843-1
  11. MicroRNA gene polymorphisms and the risk of colorectal cancer vol.13, pp.5, 2017, https://doi.org/10.3892/ol.2017.5885