Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Kojic Acid Protects C57BL/6 Mice from Gamma-irradiation Induced Damage

  • Wang, Kai (School of Graduate Studies, Anhui Medical University) ;
  • Liu, Chao (Department of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine) ;
  • Di, Chan-Juan (Department of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine) ;
  • Ma, Cong (Department of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine) ;
  • Han, Chun-Guang (Department of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine) ;
  • Yuan, Mei-Ru (Department of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine) ;
  • Li, Peng-Fei (Department of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine) ;
  • Li, Lu (Department of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine) ;
  • Liu, Yong-Xue (Department of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine)
  • Published : 2014.01.15
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Abstract

The radioprotective effects of a single administration of kojic acid (KA) against ionizing radiation were evaluated via assessment of 30-day survival and alterations of peripheral blood parameters of adult C57BL/6 male mice. The 30-day survival rate of mice pretreated with KA (75 or 300 mg/kg body weight, KA75 or KA300) subcutaneously 27 h prior to a lethal dose (8 Gy, 153.52 cGy/min) of gamma irradiation was higher than that of mice irradiated alone (40% or 60% vs 0%). It was observed that the white blood cell (WBC) count/the red blood cell (RBC) count, haemoglobin content, haematocrit and platelet count of mice with or without KA pretreatment as exposed to a sub-lethal dose (4 Gy, 148.14 cGy/min) of gamma irradiation decreased maximally at day 4/day 8 post-irradiation. Although the initial WBC values were low in KA300 or WR-2721 (amifostine) groups, they significantly recovered to normal at day 19, whereas in the control group they did not. The results from the cytotoxicity and cell viability assays demonstrated that KA could highly protect Chinese hamster ovary (CHO) cells against ionizing radiation with low toxicity. In summary, KA provides marked radioprotective effects both in vivo and in vitro.

Keywords

References

  1. Andrievsky GV, Bruskov VI, Tykhomyrov AA, et al (2009). Peculiarities of the antioxidant and radioprotective effects of hydrated C60 fullerene nanostuctures in vitro and in vivo. Free Radic Biol Med, 47, 786-93. https://doi.org/10.1016/j.freeradbiomed.2009.06.016
  2. Aytemir MD, Septioglu E, Calis U (2010). Synthesis and anticonvulsant activity of new kojic acid derivatives. Arzneimittelforschung, 60, 22-9.
  3. Bentley R (2006). From miso, sake and shoyu to cosmetics: a century of science for kojic acid. Nat Prod Rep, 23, 1046-62. https://doi.org/10.1039/b603758p
  4. Byon YY, Kim MH, Yoo ES, et al (2008). Radioprotective effects of fucoidan on bone marrow cells: improvement of the cell survival and immunoreactivity. J Vet Sci, 9, 359-65. https://doi.org/10.4142/jvs.2008.9.4.359
  5. Carbonneau CL, Despars G, Rojas-Sutterlin S, et al (2012). Ionizing radiation-induced expression of INK4a/ARF in murine bone marrow-derived stromal cell populations interferes with bone marrow homeostasis. Blood, 119, 717-26. https://doi.org/10.1182/blood-2011-06-361626
  6. Cassatt DR, Fazenbaker CA, Bachy CM, et al (2002). Preclinical modeling of improved amifostine (Ethyol) use in radiation therapy. Semin Radiat Oncol, 12, 97-102. https://doi.org/10.1053/srao.2002.31382
  7. Chisvert A, Sisternes J, Balaguer A, et al (2010). A gas chromatography-mass spectrometric method to determine skin-whitening agents in cosmetic products. Talanta, 81, 530-6. https://doi.org/10.1016/j.talanta.2009.12.037
  8. Chua HL, Plett PA, Sampson CH, et al (2012). Long-term hematopoietic stem cell damage in a murine model of the hematopoietic syndrome of the acuteradiation syndrome. Health Phys, 103, 356-6. https://doi.org/10.1097/HP.0b013e3182666d6f
  9. Cressier D, Prouillac C, Hernandez P, et al (2009). Synthesis, antioxidant properties and radioprotective effects of new benzothiazoles and thiadiazoles. Bioorg Med Chem, 17, 5275-84. https://doi.org/10.1016/j.bmc.2009.05.039
  10. Dhaker AS, Marwah R, Damodar R, et al (2011). In vitro evaluation of antioxidant and radioprotective properties of a novel extremophile from mud volcano: implications for management of radiation emergencies. Mol Cell Biochem, 353, 243-50. https://doi.org/10.1007/s11010-011-0792-7
  11. Emami S, Hosseinimehr SJ, Taghdisi SM, et al (2007). Kojic acid and its manganese and zinc complexes as potential radioprotective agents. Bioorg Med Chem Lett, 17, 45-8. https://doi.org/10.1016/j.bmcl.2006.09.097
  12. Floratou K, Giannopoulou E, Antonacopoulou A, et al (2012). Oxidative syress due to radiation in CD34(+) hematopoietic progenitor cells: protection by IGF-1. J Radiat Res, 53, 672-85. https://doi.org/10.1093/jrr/rrs019
  13. Hosseinimehr SJ, Emami S, Zakaryaee V, et al (2009). Radioprotectvie effects of kojic acid against mortality induced by gamma irradiation in mice. Saudi Med J, 30, 490-3.
  14. Hosseinimehr SJ, Tavakoli H, Pourheidari G, et al (2003). Radioprotective effects of citrus extract against ${\gamma}$-irradiation in mouse bone marrow cells. J Radiat Res, 44, 237-41. https://doi.org/10.1269/jrr.44.237
  15. Hosseinimehr SJ (2010). Flavonoids and genomic instability induced by ionizing radiation. Drug Discovery Today, 15, 907-18. https://doi.org/10.1016/j.drudis.2010.09.005
  16. Koukourakis MI, Kyrias G, Kakolyris S, et al (2000). Subcutaneous administration of amifostine during fractionated radiotherapy: a randomized phase II study. J Clin Oncol, 18, 2226-33.
  17. Kwak SY, Choi HR, Park KC, et al (2011). Kojic acid-amino acid amide metal complexes and their melanogenesis inhibitory activities. J Pept Sci, 17, 791-7. https://doi.org/10.1002/psc.1404
  18. Landauer MR, Davis HD, Dominitz JA, et al (1987). Dose and time relationships of the radioprotector WR-2721 on locomotor activity in mice. Pharmacol Biochem Behav, 27, 573-6. https://doi.org/10.1016/0091-3057(87)90370-4
  19. Landauer MR, Srinivasan V, Seed TM (2003). Genistein treatment protects mice from ionizing radiation injury. J Appl Toxicol, 23, 379-85. https://doi.org/10.1002/jat.904
  20. Niwa Y, Akamatsu H (1991). Kojic acid scavenges free radicals while potentiating leukocyte functions including free radical generation. Inflammation, 15, 303-15. https://doi.org/10.1007/BF00917315
  21. Nohynek GJ, Kirkland D, Marzin D, et al (2004). An assessment of the genotoxicity and human health risk of topical use of kojic acid [5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one]. Food Chem Toxicol, 42, 93-105. https://doi.org/10.1016/j.fct.2003.08.008
  22. Parrish FW, Wiley BJ, Simmons EG, et al (1966). Production of aflatoxins and kojic acid by species of Aspergillus and Penicillium. Appl Microbiol, 14, 139.
  23. PuchaIa M, Szweda-Lewandowska Z, Kiefer J (2004). The influence of radiation quality on radiation-induced hemolysis and hemoglobin oxidation of human erythrocytes. J Radiat Res, 45, 275-9. https://doi.org/10.1269/jrr.45.275
  24. Samarth RM, Goyal PK, Kumar A (2004). Protection of swiss albino mice against whole-body gamma irradiation by menthe piperita(Linn.). Phytother Res, 18, 546-50. https://doi.org/10.1002/ptr.1483
  25. Samarth RM, Panwar M, Kumar M, et al (2008). Evaluation of antioxidant and radical-scavenging activities of certain radioprotective plant extracts. Food Chemistry, 106, 868-73. https://doi.org/10.1016/j.foodchem.2007.05.005
  26. Sebastia N, Almonacid M, Villaescusa JI, et al (2013). Radioprotective activity and cytogenetic effect of resveratrol in human lymphocytes: An in vitro evaluation. Food Chem Toxicol, 51, 391-5. https://doi.org/10.1016/j.fct.2012.10.013
  27. Sebastia N, Montoro A, Montoro A, et al (2011). Assessment in vitro of radioprotective efficacy of curcumin and resveratrol. Radiation Measurements, 46, 962-6. https://doi.org/10.1016/j.radmeas.2011.05.009
  28. Suman S, Maniar M, Fornace AJ Jr, et al (2012). Administration of ON 01210.Na after exposure to ionizing radiation protects bone marrow cells by attenuating DNA damage response. Radiat Oncol, 7, 6. https://doi.org/10.1186/1748-717X-7-6
  29. Sutherland BM, Bennett PV, Cintron-Torres N, et al (2002). Clustered DNA damages induced in human hematopoietic cells by low doses of ionizing radiation. J Radiat Res, 43, 149-52. https://doi.org/10.1269/jrr.43.S149
  30. Tanaka R, Tsujii H, Yamada T, et al (2009). Novel 3alpha -methoxyse rrat-14-en-21beta-ol (PJ-1) and 3betamethoxyserrat -14-en-21beta-ol (PJ-2)-curcumin, kojic acid, quercetin, and baicalein conjugates as HIV agents. Bioorg Med Chem, 17, 5238-46. https://doi.org/10.1016/j.bmc.2009.05.049
  31. Wang Y, Schulte BA, LaRue AC, et al (2006). Total body irradiation selectively induces murine hematopoietic stem cell senescence. Blood, 107, 358-66. https://doi.org/10.1182/blood-2005-04-1418
  32. Wei Y, Zhang C, Zhao P, et al (2011). A new salicylic acidderivatized kojic acid vanadyl complex: synthesis, characterization and anti-diabetic therapeutic potential. J Inorg Biochem, 105, 1081-1085. https://doi.org/10.1016/j.jinorgbio.2011.05.008
  33. Williams JP, McBride WH (2011). After the bomb drops: a new look at radiation-induced multiple organ dysfunction syndrome (MODS). Int J Radiat Biol, 87, 851-68. https://doi.org/10.3109/09553002.2011.560996
  34. Yankelevitz DF, Henschke CI, Knapp PH, et al (1991). Effect of radiation therapy on thoracic and lumbar bone marrow: evaluation with MR imaging. AJR Am J Roentgenol, 157, 87-92. https://doi.org/10.2214/ajr.157.1.1904679

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