Asian Pacific Journal of Cancer Prevention

  • 제15권1호
  • /
  • Pages.381-384
  • /
  • 2014
  • /
  • 1513-7368(pISSN)
  • /
  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
권호 표지
DOI QR코드

DOI QR Code

Dickkopf-1 Levels in Turkish Patients with Bladder Cancer and its Association with Clinicopathological Features

  • Kaba, Mehmet (Department of Urology, Faculty of Medicine, Yuzuncu Yil University) ;
  • Pirincci, Necip (Department of Urology, Faculty of Medicine, Yuzuncu Yil University) ;
  • Benli, Erdal (Department of Urology, Faculty of Medicine, Ordu University) ;
  • Gecit, Ilhan (Department of Urology, Faculty of Medicine, Yuzuncu Yil University) ;
  • Gunes, Mustafa (Department of Urology, Faculty of Medicine, Yuzuncu Yil University) ;
  • Yuksel, Mehmet Bilgehan (Department of Urology, Faculty of Medicine, Celal Bayar University) ;
  • Tok, Adem (Department of Urology, Faculty of Medicine, Bulent Ecevit University) ;
  • Kemik, Ahu Sarbay (Department of Biochemistry, Faculty of Medicine, Istanbul University)
  • 발행 : 2014.01.15
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Background: Evidence indicates that Dickkopf-1 (DKK-1) levels may be a biomarker for cancer risk. The aim of this study was to assess DKK-1 and its correlation with clinic-pathological features in patients with bladder cancer. Materials and Methods: DKK-1 levels were determined in serum samples from 90 patients with bladder cancer before transurethral tumor resection. The concentrations of DKK-1 were determined by using enzyme linked immune-sorbent assay (ELISA). Results: Elevated preoperative DKK-1 levels were associated with tumor stage (p<0.001), grade (p<0.001) and histological grade (p<0.001). Conclusions: The results of our study demonstrated that the level of serum DKK-1 is correlated with both disease progression and increase in the tumor grade. Preoperative serum DKK-1 elevation may thus represent a novel marker for the determination of bladder cancer and the detection of patients with a likely poor clinical outcome.

키워드

참고문헌

  1. Glinka A, Wu W, Onichtchouk D, Blumenstock C, Niehrs C. (1997) Head induction by simultaneous repression of Bmp and Wnt signaling in Xenopus. Nature, 389, 517-19. https://doi.org/10.1038/39092
  2. Glinka A, Wu W, Delius H, et al (1998). Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature, 391, 357-62. https://doi.org/10.1038/34848
  3. Gomceli I, Bostanci EB, Ozer I, et al (2012). A novel screening biomarker in gastric cancer:serum Dickkopf-1. Hepatogastroenterology, 59, 1661-64.
  4. Jemal A, Murray T, Samuels A, et al (2003). Cancer statistics. CA Cancer J Clin, 53, 5-26. https://doi.org/10.3322/canjclin.53.1.5
  5. Jiang T, Wang S, Huang L, Zhang S (2009). Clinical significance of serum DKK-1 in patients with gynecological cancer. Int J Gynecol Cancer, 19, 1177-81. https://doi.org/10.1111/IGC.0b013e31819d8b2d
  6. Jiang T, Huang L, Zhang S (2013). Jun DKK-1 is a serum as a clinical and prognostic factor in patients with cervical cancer. Int J Biol Markers, 28, 221-25. https://doi.org/10.5301/jbm.5000005
  7. Kemik O, Kemik AS, Sumer A, et al (2011 Aug). Relationship between clinicopathologic variables and serum and tissue levels of Dickkopf-1 in patients with rectal cancer. J Investig Med, 59, 947-50.
  8. Lee HS, Lee HE, Park do J, et al (2012). Clinical significance of serum and tissue Dickkopf-1 levels in patients with gastric cancer. Clin Chim Acta, 413, 1753-60. https://doi.org/10.1016/j.cca.2012.07.003
  9. Niehrs C (2006). Function and biological roles of the Dickkopf family of Wnt modulators. Oncogene, 25, 7469-81. https://doi.org/10.1038/sj.onc.1210054
  10. Patil MA, Cua MS, Pan KH, et al (2005). An integrated data analysis approach to characterize genes highly expressed in hepatocellular carcinoma. Oncogene, 24, 3737-47. https://doi.org/10.1038/sj.onc.1208479
  11. Sato N, Yamabuki T, Takano A, et al (2010). Wnt inhibitor Dickopf-1 as a target for passive cancer immunotherapy. Cancer Research, 70, 5326-36. https://doi.org/10.1158/0008-5472.CAN-09-3879
  12. Soydinc HO, Duranyildiz D, Camlica H, Oral EN, Yasasever V (2011). Lack of diagnostic potential f Dickkopf-1 in colon and rectum cancers. Asian Pac J Cancer Prev, 12, 3187-9.
  13. Tung EK, Mak CK, Fatima S, et al (2011). Clinicopathological and prognostic significance of serum and tissue Dicckopf-1 levels in human hepatocellular carcinoma. Liver Int, 31, 1494-504. https://doi.org/10.1111/j.1478-3231.2011.02597.x
  14. Wirths O, Waha A, Weggen S, et al (2003). Overexpression of human Dickkopf-1, an antagonist of wingless/Wnt signaling, in human hepatoblastomas and Wilms' tumors. Lab Invest, 83, 429-34. https://doi.org/10.1097/01.LAB.0000059926.66359.BD
  15. Yang S, Chen GD, Fang F, et al (2013). Dickkopf-1: as a diagnostic and prognostic serum marker for early hepatocellular carcinoma. Int J Biol Markers, 8, 286-97.