Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Multicenter Analysis of Gestational Trophoblastic Neoplasia in Turkey

  • Ozalp, Sabit Sinan (Department of Obstetrics and Gynecology, School of Medicine, Eskisehir Osmangazi University) ;
  • Telli, Elcin (Department of Obstetrics and Gynecology, School of Medicine, Eskisehir Osmangazi University) ;
  • Oge, Tufan (Department of Obstetrics and Gynecology, School of Medicine, Eskisehir Osmangazi University) ;
  • Tulunay, Gokhan (Department of Obstetrics and Gynecology, Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital) ;
  • Boran, Nurettin (Department of Obstetrics and Gynecology, Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital) ;
  • Turan, Taner (Department of Obstetrics and Gynecology, Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital) ;
  • Yenen, Mufit (Department of Obstetrics and Gynecology, Gulhane Military Medical Academy and Medical School) ;
  • Kurdoglu, Zehra (Department of Obstetrics and Gynecology, School of Medicine, Yuzuncu Yil University) ;
  • Ozler, Ali (Department of Obstetrics and Gynecology, School of Medicine, Dicle University) ;
  • Yuce, Kunter (Department of Obstetrics and Gynecology, Hacettepe University, School of Medicine) ;
  • Ulker, Volkan (Department of Obstetrics and Gynecology, Kanuni Sultan Suleyman Teaching and Research Hospital) ;
  • Arvas, Macit (Department of Obstetrics and Gynecology, School of Medicine, Cerrahpasa University) ;
  • Demirkiran, Fuat (Department of Obstetrics and Gynecology, School of Medicine, Cerrahpasa University) ;
  • Bese, Tugan (Department of Obstetrics and Gynecology, School of Medicine, Cerrahpasa University) ;
  • Tokgozoglu, Nedim (Department of Obstetrics and Gynecology, School of Medicine, Cerrahpasa University) ;
  • Onan, Anil (Department of Obstetrics and Gynecology, School of Medicine, Gazi University) ;
  • Sanci, Muzaffer (Department of Obstetrics and Gynecology, Ege Gynecology and Maternity Training and Research Hospital) ;
  • Gokcu, Mehmet (Department of Obstetrics and Gynecology, Ege Gynecology and Maternity Training and Research Hospital) ;
  • Tosun, Gokhan (Department of Obstetrics and Gynecology, Ege Gynecology and Maternity Training and Research Hospital) ;
  • Dikmen, Yilmaz (Department of Obstetrics and Gynecology, School of Medicine, Ege University) ;
  • Ozsaran, Aydin (Department of Obstetrics and Gynecology, School of Medicine, Ege University) ;
  • Terek, Mustafa Cosan (Department of Obstetrics and Gynecology, School of Medicine, Ege University) ;
  • Akman, Levent (Department of Obstetrics and Gynecology, School of Medicine, Ege University) ;
  • Yetimalar, Hakan (Department of Obstetrics and Gynecology, Izmir Ataturk Training and Research Hospital) ;
  • Kilic, Derya Sakarya (Department of Obstetrics and Gynecology, Izmir Ataturk Training and Research Hospital) ;
  • Gungor, Tayfun (Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital) ;
  • Ozgu, Emre (Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital) ;
  • Yildiz, Yunus (Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital) ;
  • Kokcu, Arif (Department of Obstetrics and Gynecology, School of Medicine, Ondokuz Mayis University) ;
  • Kefeli, Mehmet (Department of Obstetrics and Gynecology, School of Medicine, Ondokuz Mayis University) ;
  • Kuruoglu, Serkan (Department of Obstetrics and Gynecology, School of Medicine, Ondokuz Mayis University) ;
  • Yuksel, Hasan (Department of Obstetrics and Gynecology, School of Medicine, Adnan Menderes University) ;
  • Guvenal, Tevfik (Department of Obstetrics and Gynecology, School of Medicine, Celal Bayar University) ;
  • Hasdemir, Pinar Solmaz (Department of Obstetrics and Gynecology, School of Medicine, Celal Bayar University) ;
  • Ozcelik, Bulent (Department of Obstetrics and Gynecology, School of Medicine, Erciyes University) ;
  • Serin, Serdar (Department of Obstetrics and Gynecology, School of Medicine, Erciyes University) ;
  • Dolanbay, Mehmet (Department of Obstetrics and Gynecology, School of Medicine, Erciyes University) ;
  • Arioz, Dagistan Tolga ;
  • Tuncer, Nadire (Department of Obstetrics and Gynecology, School of Medicine, Afyon Kocatepe University) ;
  • Bozkaya, Hasan (Department of Obstetrics and Gynecology, School of Medicine, Karadeniz Technical University) ;
  • Guven, Suleyman (Department of Obstetrics and Gynecology, School of Medicine, Karadeniz Technical University) ;
  • Kulaksiz, Deniz (Department of Obstetrics and Gynecology, School of Medicine, Karadeniz Technical University) ;
  • Varol, Fusun (Department of Obstetrics and Gynecology, School of Medicine, Trakya University) ;
  • Ali, Yanik (Department of Obstetrics and Gynecology, School of Medicine, Cumhuriyet University) ;
  • Ogurlu, Gonca (Department of Obstetrics and Gynecology, School of Medicine, Cumhuriyet University) ;
  • Simsek, Tayyup (Department of Obstetrics and Gynecology, School of Medicine, Akdeniz University) ;
  • Toptas, Tayfun (Department of Obstetrics and Gynecology, School of Medicine, Akdeniz University) ;
  • Dogan, Selen (Department of Obstetrics and Gynecology, School of Medicine, Akdeniz University) ;
  • Camuzoglu, Hakan (Department of Obstetrics and Gynecology, School of Medicine, Harran University) ;
  • Api, Murat (Department of Obstetrics and Gynecology, Research and Training Hospital, Zeynep Kamil Maternity and Pediatric) ;
  • Guzin, Kadir (Department of Obstetrics and Gynecology, Goztepe Training and Research Hospital, Istanbul Medeniyet University) ;
  • Eray, Caliskan (Department of Obstetrics and Gynecology, School of Medicine, Kocaeli University) ;
  • Doger, Emek (Department of Obstetrics and Gynecology, School of Medicine, Kocaeli University)
  • Published : 2014.04.30
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Abstract

Background: To evaluate the incidence, diagnosis and management of GTN among 28 centers in Turkey. Materials and Methods: A retrospective study was designed to include GTN patients attending 28 centers in the 10-year period between January 2003 and May 2013. Demographical characteristics of the patients, histopathological diagnosis, the International Federation of Gynecology and Obstetrics (FIGO) anatomical and prognostic scores, use of single-agent and multi-agent chemotherapy, surgical interventions and prognosis were evaluated. Results: From 2003-2013, there were 1,173,235 deliveries and 456 GTN cases at the 28 centers. The incidence was calculated to be 0.38 per 1,000 deliveries. According to the evaluated data of 364 patients, the median age at diagnosis was 31 years (range, 15-59 years). A histopathological diagnosis was present for 45.1% of the patients, and invasive mole, choriocarcinoma and PSTTs were diagnosed in 22.3% (n=81), 18.1% (n=66) and 4.7% (n=17) of the patients, respectively. Regarding final prognosis, 352 (96.7%) of the patients had remission, and 7 (1.9%) had persistence, whereas the disease was mortal for 5 (1.4%) of the patients. Conclusions: Because of the differences between countries, it is important to provide national registration systems and special clinics for the accurate diagnosis and treatment of GTN.

Keywords

References

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