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Risk Factors for Lung Cancer in the Pakistani Population

  • 발행 : 2014.04.01

초록

Background: Lung cancer is one of the most prevalent malignancies in the world and both incidence and mortality rates are continuing to rise in Pakistan. However, epidemiological studies to identify common lung cancer determinants in the Pakistani population have been limited. Materials and Methods: In this retrospective case-control study, 400 cases and 800 controls were enrolled from different hospitals of all provinces of Pakistan. Information about socio-demographic, occupational, lifestyle and dietary variables was extracted by questionnaire from all subjects. Odd ratios (ORs) and 95% confidence intervals (CIs) were calculated. and dose-response associations were also assessed for suitable factors. Results: Strong associations were observed for smoking (OR=9.4, 95%CI=6.9-12.8), pesticide exposure (OR=5.1, 95%CI=3.1-8.3), exposure to diesel exhaust (OR=3.1, 95%CI=2.1-4.5), red meat consumption (OR=2.9, 95%CI=1.8-4.7) and chicken consumption (OR=2.8, 95%CI=1.7-49). Other associated factors observed were welding fumes (OR=2.5, 95%CI=1.0-6.5), sedentary living (OR=2.0, 95%CI=1.6-2.6), family history (OR=2.0, 95%CI=0.8-4.9), wood dust (OR=1.9, 95%CI=1.2-3.1), tea consumption (OR=1.8, 95%CI=1.2-2.6), coffee consumption (OR=1.8, 95%CI=1.1-2.8), alcoholism (OR=1.7, 95%CI=1.1-2.5) and asbestos exposure(OR=1.5, 95%CI=0.5-4.4). Consumption of vegetables (OR=0.3, 95%CI=0.2-0.4), juices (OR=0.3, 95%CI=0.3-0.4), fruits (OR=0.7, 95%CI=0.5-0.9) and milk (OR=0.6, 95%CI=0.5-0.8) showed reduction in risk of lung cancer. Strongest dose-response relationships were observed for smoking ($X^2=333.8$, $p{\leq}0.0000001$), pesticide exposure ($X^2=50.9$, $p{\leq}0.0000001$) and exposure to diesel exhaust ($X^2=51.8$, $p{\leq}0.0000001$). Conclusions: Smoking, pesticide exposure, diesel exhaust and meat consumption are main lung cancer determinants in Pakistan. Consuming vegetables, fruits, milk and juices can reduce the risk of lung cancer risk, as in other countries.

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참고문헌

  1. Ahmed K, Abdullah-Al-Emran, Jesmin T, et al (2013). Early detection of lung cancer risk using data mining, Asian Pac J Cancer Prev, 14, 595-8. https://doi.org/10.7314/APJCP.2013.14.1.595
  2. Ahn J, Albanes D, Peters U, et al (2007). Dairy products, calcium intake, and risk of prostate cancer in the prostate, lung, colorectal and ovarian cancer screening trial. Cancer Epidemiol Biomarkers, 16, 2623-30. https://doi.org/10.1158/1055-9965.EPI-07-0601
  3. Alam, SE (1998). Prevalence and pattern of smoking in Pakistan. journal of Pakistan. Medical Association, 48, 64-6.
  4. Alavanja MC, Field RW, Sinha R, et al (2001). Lung cancer risk and red meat consumption among Iowa women. Lung Cancer, 34, 37-46.
  5. Alavanja MC, Ross MK, Bonner MR (2013). Reply to Increased cancer burden among pesticide applicators and others due to pesticide exposure. CA Cancer J Clin, 63, 366-7. https://doi.org/10.3322/caac.21193
  6. Attfield MD, Schleiff PL, Lubin JH, et al (2012). The diesel exhaust in miners study: a cohort mortality study with emphasis on lung cancer. J Natl Cancer Inst, 104, 869-83. https://doi.org/10.1093/jnci/djs035
  7. Axelsson G, Rylander R (2002). Diet as risk for lung cancer: a swedish case-control study. Nutr Cancer, 44, 145-51. https://doi.org/10.1207/S15327914NC4402_04
  8. Bagnardi V, Randi G, Lubin J, et al (2010). Alcohol consumption and lung cancer risk in the environment and genetics in lung cancer etiology. Am J Epidemiol, 171, 36-44. https://doi.org/10.1093/aje/kwp332
  9. Bailey WJE, Amos CI, Pinney SM, et al, (2004). A major lung cancer susceptibility locus maps to chromosome 6q23-25. Am J Hum Genet, 75, 460-74. https://doi.org/10.1086/423857
  10. Baker JA, McCann SE, Reid ME, et al, (2005). Associations between black tea and coffee consumption and risk of lung cancer among current and former smokers. Nutr Cancer. 52, 15-21. https://doi.org/10.1207/s15327914nc5201_2
  11. Bhaskarapillai B, Kumar SS, Balasubramanian S (2013). Lung cancer in malabar cancer center in kerala-a descriptive analysis. Asian Pac J Cancer Prev, 13, 4639-43. https://doi.org/10.7314/APJCP.2012.13.9.4639
  12. Bhatti P, Newcomer L, Onstad L, et al (2011). Wood dust exposure and risk of lung cancer. Occup Environ Med, 68, 599-604. https://doi.org/10.1136/oem.2010.060004
  13. Bruske HI, Mohner M, Pohlabeln H, et al (2000). Occupational lung cancer risk for men in Germany, results from a pooled case-control study. Am J Epidemiol, 151, 384-95. https://doi.org/10.1093/oxfordjournals.aje.a010218
  14. Cote ML, Liu M, Bonassi S, et al (2012). Increased risk of lung cancer in individuals with a family history of the disease: a pooled analysis from the international lung cancer consortium. Eur J Cancer, 48, 1957-68. https://doi.org/10.1016/j.ejca.2012.01.038
  15. Davoodi H, Esmaeili S, Mortazavian AM, (2013). Effects of milk and milk products consumption on cancer: a review-comprehensive reviews in food science and food safety, 12, 249-64. https://doi.org/10.1111/1541-4337.12011
  16. Ferreccio C, Gonzalez C, Milosavjlevic V, et al (2000). Lung cancer and arsenic concentrations in drinking water in Chile. Epidemiology, 11, 673-9. https://doi.org/10.1097/00001648-200011000-00010
  17. Ganesh B, Sushama S, Monika S, Suvarna P (2011 ). A case-control study of risk factors for lung cancer in Mumbai, India. Asian Pacific J Cancer Prev, 12, 357-62.
  18. Garshick E, Schenker MB, Munoz A, eta al (1987). A case-control study of lung cancer and diesel exhaust exposure in railroad workers. Am Rev Respir Dis, 135, 1242-8. https://doi.org/10.1164/arrd.1987.135.6.1242
  19. Gnagnarella P, Maisonneuve p, Bellomi M, et al (2013). Red meat, mediterranean diet and lung cancer risk among heavy smokers in the cosmos screening study. Ann Oncol, 10, 2606-11.
  20. Hashibe M, Siwakoti B, Wei1 M, et al (2010). Socioeconomic status and lung cancer risk in Nepal. Asian Pacific J Cancer Prev, 12, 1083-8.
  21. Hussain MR, Khan SA, Bukhari MH (2009). Role of smoking in primary pulmonary malignancies in central punjab. Annals, 17, 18-21.
  22. International Agency for Research on Cancer, IARC (2012). diesel engine exhaust carcinogenic (press release no 213), Lyon, France.
  23. International Agency for Research on Cancer, IARC (1994). Tobacco smoking and involuntary tobacco smoke, IARC monographs on the evaluation of the carcinogenic risk to human, Lyon, France.
  24. Kwong SL, Chen MS, Snipes KP, Bal DG, Wright WE (2005). Asian subgroups and cancer incidence and mortality rates in California. Cancer, 12, 2975-598
  25. Lam TK, Cross AJ, Consonni D, et al (2009). Intakes of red meat, processed meat, and meat mutagens increase lung cancer risk. Cancer Res, 69, 932-9. https://doi.org/10.1158/0008-5472.CAN-08-3162
  26. Lam WK (2005). Lung cancer in Asian women, the environment and genes. Respirology, 4, 408-17.
  27. Lim WY, Chuah KL, Eng P, et al (2011). Meat consumption and risk of lung cancer among never-smoking women. Nutr Cancer, 63, 850-9. https://doi.org/10.1080/01635581.2011.589961
  28. Mannetje A, Brennan P, Zaridze D, et al (2012). Welding and lung cancer in central and eastern Europe and the United Kingdom. Am J Epidemiol, 10, 706-4.
  29. Mannisto S, Smith-Warner SA, Spiegelman D, et al (2004). Dietary carotenoids and risk of lung cancer in a pooled analysis of seven cohort studies. Cancer Epidemiol Biomarkers Prev, 13, 40-8. https://doi.org/10.1158/1055-9965.EPI-038-3
  30. Markowitz SB, Levin SM, Miller A, Morabia A (2013). Asbestos, asbestosis, smoking, and lung cancer, new findings from the north American insulator cohort. Am J Respir Crit Care Med, 188, 90-6. https://doi.org/10.1164/rccm.201302-0257OC
  31. Matteis DS, Consonni D, Pesatori AC, et al (2013). Are women who smoke at higher risk for lung cancer than men who smoke?. Am J Epidemiol, 7, 601-12.
  32. Mauderly JL, Jones RK, Griffith WC, Henderson RF, McClellan RO (1987). Diesel exhaust is a pulmonary carcinogen in rats exposed chronically by inhalation. Fundam Appl Toxicol, 9, 208-21. https://doi.org/10.1016/0272-0590(87)90044-3
  33. Menvielle G, Luce D, Fevotte J, et al (2003). Occupational exposures and lung cancer in new caledonia. Occup Environ Med, 60, 584-9. https://doi.org/10.1136/oem.60.8.584
  34. Michael CR, Alavanja MK, Ross MR, Bonner (2013). Increased cancer burden among pesticide applicators and others due to pesticide exposure. A Cancer J Clin, 63, 120-2. https://doi.org/10.3322/caac.21170
  35. Michael CR, Alavanja, Dosemeci M, et al (2004). Pesticides and lung cancer risk in the agricultural health study cohort. Am J Epidemiol, 160, 876-85. https://doi.org/10.1093/aje/kwh290
  36. Pesatori AC, Sontag JM, Lubin JH, Consonni D, Blair A (1994). Cohort mortality and nested case-control study of lung cancer among structural pest control workers in Florida (United States). Cancer Causes Control, 5, 310-8. https://doi.org/10.1007/BF01804981
  37. Sergeant, ESG (2014). Epitools Epidemiological Calculators. Ausvet animal health services and A ustralian biosecurity cooperative research centre for emerging infectious disease.
  38. Steenland K, Deddens J, Stayner L (1998). Diesel exhaust and lung cancer in the trucking industry: exposure-response analyses and risk assessment. Am J Ind Med, 34, 220-8. https://doi.org/10.1002/(SICI)1097-0274(199809)34:3<220::AID-AJIM3>3.0.CO;2-Z
  39. Steenland K, Silverman DT, Hornung RW (1990). Case-control study of lung cancer and truck driving in the Teamsters Union. Am J Public Health, 80, 670-4. https://doi.org/10.2105/AJPH.80.6.670
  40. Stellman SD, Takezaki T, Wang L, et al (2001). Smoking and lung cancer risk in American and Japanese men: an international case-control study. Cancer Epidemiol Biomarkers Prev, 11, 1193-9.
  41. Sun S, Schiller JH, Gazdar AF (2007). Lung cancer in never smokers, a different disease. Nature Rev, 7, 778-90.
  42. Tang N, Wu Y, Ma J, Wang B, Yu R (2010). Coffee consumption and risk of lung cancer: a meta-analysis. Lung Cancer, 67, 17-22. https://doi.org/10.1016/j.lungcan.2009.03.012
  43. Tang N, Wu Y, Zhou B, Wang B, Yu R (2009). Green tea, black tea consumption and risk of lung cancer, a meta-analysis. Lung Cancer, 65, 274-83. https://doi.org/10.1016/j.lungcan.2008.12.002
  44. Tas D, Okutan O, Kaya H, Kartaloglu Z, Kunter, E (2008). Analysis of 138 cases of lung cancer in a training hospital compared to the data of lung cancer cases diagnosed ten years previously. Marmara Med J, 213, 231-7.
  45. Wahab M, Boroumand N, Castro C, El-Zeky F, Eltorky M (2007). Changing trends in the distribution of the histologic types of lung cancer, a review of 4,439 cases. Ann Diagn Pathol, 112, 89-96.
  46. Wright ME, Mayne ST, Swanson CHA, Sinha R (2003). Dietary carotenoids, vegetables and lung cancer risk in women: the missouri women's health study (United States). Cancer Causes Control, 14, 85-96. https://doi.org/10.1023/A:1022565601937
  47. Wu AH, Yu MC (2006). Tea, hormone related cancers and endogenous hormone levels. Mol Nutr Food Res, 50, 160-9. https://doi.org/10.1002/mnfr.200500142
  48. Yang M, Saiyi P, Shi WW, Kenneth C, Johnson (2003). Canadian cancer registries epidemiology research group. Am J Epidemiol, 158, 564-75. https://doi.org/10.1093/aje/kwg186
  49. Yang WS, Wong MY, Vogtmann E, et al (2012). Meat consumption and risk of lung cancer: evidence from observational studies. Ann Oncol, 23, 3163-70. https://doi.org/10.1093/annonc/mds207
  50. Yin ZH, Cui ZG, Ren YW, et al (2013). TP63 gene polymorphisms, cooking oil fume exposure and risk of lung adenocarcinoma in Chinese non-smoking females. Asian Pacific J Cancer Prev, 14, 6519-22. https://doi.org/10.7314/APJCP.2013.14.11.6519

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