Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Counts of Slackia sp. strain NATTS in Intestinal Flora are Correlated to Serum Concentrations of Equol both in Prostate Cancer Cases and Controls in Japanese Men

  • Sugiyama, Yukiko (Department of Public Health, Sapporo Medical University School of Medicine) ;
  • Nagata, Yoshie (Department of Nursing, Sapporo Medical University School of Medicine) ;
  • Fukuta, Fumimasa (Department of Urology, Sapporo Medical University School of Medicine) ;
  • Takayanagi, Akio (Department of Urology, Sapporo Medical University School of Medicine) ;
  • Masumori, Naoya (Department of Urology, Sapporo Medical University School of Medicine) ;
  • Tsukamoto, Taiji (Department of Urology, Sapporo Medical University School of Medicine) ;
  • Akasaka, Hiroshi (Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine) ;
  • Ohnishi, Hirofumi (Department of Public Health, Sapporo Medical University School of Medicine) ;
  • Saito, Shigeyuki (Department of Nursing, Sapporo Medical University School of Medicine) ;
  • Miura, Tetsuji (Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine) ;
  • Moriyama, Kaoru (Yakult Central Institute for Microbiological Research) ;
  • Tsuji, Hirokazu (Yakult Central Institute for Microbiological Research) ;
  • Akaza, Hideyuki (Research Center for Advanced Science and Technology, University of Tokyo) ;
  • Mori, Mitsuru (Department of Public Health, Sapporo Medical University School of Medicine)
  • Published : 2014.03.30
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Abstract

Background: Isoflavones, which are included in soybeans, have been suggested to protect against prostate cancer. Equol, one of isoflavones, is an intestinally derived bacterial metabolite of daidzein. A newly identified equol-producing bacterium, Slackia sp. strain NATTS, with a high equol-producing activity was isolated from human feces in Japanese adults. Counts of Slackia sp. strain NATTS in intestinal flora have not been assessed with regard to prostate cancer risk. In this study, we investigated the association of serum isoflavones and counts of Slackia sp. strain NATTS with prostate cancer risk in a case-control study. Materials and Methods: Concentrations of isoflavones and counts of Slackia sp. strain NATTS in feces were measured from 44 patients with prostate cancer and 28 hospital controls. The risk of prostate cancer was evaluated in terms of odds ratios (ORs) and 95% confidence intervals (CIs) by the logistic regression analysis. Results: The detection proportions of Slackia sp. strain NATTS in cases and controls were 34.1% and 25.0%, respectively. Counts of Slackia sp. strain NATTS were significantly correlated with serum concentrations of equol both in cases and controls (Spearman correlation coefficients, $r_s$=0.639 and $r_s$=0.572, p<0.01, respectively). Serum concentrations of genistein, daidzein, glycitein, and equol were not significantly associated with risk of prostate cancer. Conclusions: This study found that counts of Slackia sp. strain NATTS correlated with serum concentrations of equol both in prostate cancer cases and controls, but serum isoflavone concentrations were not associated with risk of prostate cancer in our patients.

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References

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