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Computer Tomography and Magnetic Resonance Image Manifestations of Primary Hepatic Neuroendocrine Cell Carcinomas

  • Huang, Juan (Department of Radiology, West China Hospital, Sichuan University) ;
  • Yu, Jian-Qun (Department of Radiology, West China Hospital, Sichuan University) ;
  • Sun, Jia-Yu (Department of Radiology, West China Hospital, Sichuan University)
  • Published : 2014.03.30

Abstract

Aim: This study aims to investigate the manifestation of CT, MRI and dynamic enhanced scans for primary hepatic neuroendocrine cell carcinoma. Methods: CT or MRI arterial and venous phase scan images of 19 cases of pathologically confirmed PHNEC were retrospectively analyzed. Results: 14 cases (73.68%) with single lesion, 5 cases (26.3%) with multiple lesions, with an average diameter of 13.2 cm. Some 12 cases (63.16%) showed inhomogeneous enhancement, seven cases (36.8%) showed homogeneous enhancement, 13 cases (68.4%) demonstrated significant enhancement in the arterial phase, 13 cases (68.4%) had significantly enhanced portal venous phase including 7 cases (36.8 %) with portal venous phase density or signal above the arterial phase and 5 cases (26.3%) with the portal vein density or signal below the arterial phase. Seven cases (36.8%) had continued strengthened separate shadows in the center of the lesion. Thrombosis were not seen in portal veins. Conclusion: CT and MRI images of liver cell neuroendocrine carcinoma have certain characteristics that can provide valuable information for diagnosis and differential diagnosis.

Keywords

References

  1. Bader TR, Semelka RC, Chiu VC, Armao DM, Woosley JT (2001). MRI of carcinoid tumors: spectrum of appearances in the gastrointestinal tract and liver. J Magn Reson Imaging, 14, 261-9. https://doi.org/10.1002/jmri.1182
  2. Baek SH, Yoon JH, Kim KW (2013). Primary hepatic neuroendocrine tumor: gadoxetic acid (Gd-EOB-DTPA)- enhanced magnetic resonance imaging. Acta Radiol, 2, 2-6.
  3. Chang S, Choi D, Lee SJ, et al (2007). Neuroendocrine neoplasms of the gastrointestinal tract: classification, pathologic basis, and imaging features. Radiographics, 27, 1667-79 https://doi.org/10.1148/rg.276075001
  4. Hamanaka M, Nakahira S, Takeda Y, et al (2012). A case of primary neuroendocrine carcinoma of the bile duct. Gan To Kagaku Ryoho, 39, 2125-7.
  5. Huang YQ, Xu F, Yang JM, Huang B (2010). Primary hepatic neuroendocrine carcinoma: clinical analysis of 11 cases. Hepatobiliary Pancreat Dis Int, 9, 44-8.
  6. Kim JE, Lee WJ, Kim SH, et al (2011). Three-phase helical computed tomographic findings of hepatic neuroendocrine tumors: pathologic correlation with revised WHO classification. J Comput Assist Tomogr, 35, 697-702. https://doi.org/10.1097/RCT.0b013e318231c6d8
  7. Krohn M, Grieser C, Weichert W, Pascher A, Denecke T (2011). Well-differentiated neuroendocrine carcinoma mimicking an echinococcus cyst ofthe liver in CT-MRI findings with hepatocyte specific contrast material. J Gastrointestin Liver Dis, 20, 439-42.
  8. Li RK, Zhao J, Rao SX, et al (2013). Primary hepatic neuroendocrine carcinoma: MR imaging findings including preliminary observation on diffusion-weighted imaging. Abdom Imaging, 38, 1269-76. https://doi.org/10.1007/s00261-013-0029-1
  9. Modlin IM, Oberg K, Chung DC, et al (2008). Gastroenteropancreatic neuroendocrine tumours. Lancet Oncol, 9, 61-72. https://doi.org/10.1016/S1470-2045(07)70410-2
  10. Park CH, Chung JW, Jang SJ, et al (2012). Clinical features and outcomes of primary hepatic neuroendocrine carcinomas. J Gastroenterol Hepatol, 27, 1306-11 https://doi.org/10.1111/j.1440-1746.2012.07117.x
  11. Pilichowska M, Kimura N, Ouchi A, et al (1999). Primary hepatic carcinoid and neuroendocrine carcinoma: clinicopathological and immunohistochemical study of five cases. Pathol Int, 49, 318-24. https://doi.org/10.1046/j.1440-1827.1999.00866.x
  12. Rufini V, Calcagni ML, Baum PR (2006). Imaging of neuroendocrine tumors. Sem Nucl Med, 36, 228-47. https://doi.org/10.1053/j.semnuclmed.2006.03.007
  13. Schwartz G, Colanta A, Gaetz H, Olichney J, Attiyeh F (2008). Primary carcinoid tumors of the liver. World J Surg Oncol, 6, 91. https://doi.org/10.1186/1477-7819-6-91
  14. Solcia E, Kloppel G, Sobin LH (2000). WHO histologic typing of endocrine tumours. 2nd ed. Springer: Berlin.
  15. Tohyama T, Matsui K, Kitagawa K (2005). Primary hepatic carcinoid tumor with carcinoid syndrome and carcinoid heart disease: A case report of a patient on long-term follow-up. Intern Med, 44, 958-62. https://doi.org/10.2169/internalmedicine.44.958
  16. Ulusan S, Kizilkilic O, Yildirim T, et al (2005). Primary hepatic carcinoid tumor: dynamic CT findings. Abdom Imaging, 30, 281-5. https://doi.org/10.1007/s00261-004-0241-0
  17. Yalav O, Ulku A, Akcam TA, Demiryurek H, Doran F (2012). Primary hepatic neuroendocrine tumor: Five cases with different preoperative diagnoses. Turk J Gastroenterol, 23, 272-8.
  18. Yao JC, Hassan M, Phan A, et al (2008). One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35, 825 cases in the United States. J Clin Oncol, 26, 3063-72. https://doi.org/10.1200/JCO.2007.15.4377
  19. Zeng YJ, Liu L, Wu H, et al (2013). Clinicopathological features and prognosis of gastroenteropancreatic neuroendocrine tumors: analysis from a single-institution. Asian Pac J Cancer Prev, 14, 5775-81. https://doi.org/10.7314/APJCP.2013.14.10.5775

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