Asian Pacific Journal of Cancer Prevention

  • 제15권5호
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  • Pages.1943-1948
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  • 2014
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Clinical Determinants of Weight Loss in Patients with Esophageal Carcinoma During Radiotherapy: a Prospective Longitudinal View

  • Jiang, Nan (School of Nursing, Tianjin Medical University) ;
  • Zhao, Jin-Zhi (School of Nursing, Tianjin Medical University) ;
  • Chen, Xiao-Cen (Department of Radiotherapy, Tianjin Medical University Cancer Hospital) ;
  • Li, Li-Ya (School of Nursing, Tianjin Medical University) ;
  • Zhang, Li-Juan (School of Nursing, Tianjin Medical University) ;
  • Zhao, Yue (School of Nursing, Tianjin Medical University)
  • 발행 : 2014.03.01
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초록

Purpose: The prevalence of weight loss in esophageal carcinoma patients is high and associated with impairment of physical function, increased psychological distress and low quality of life. It is not known which factors may contribute to weight loss in patients with esophageal carcinoma during radiotherapy in China. The objective of this study was to identify the associated demographic and clinical factors influencing weight loss. Methods: We evaluated 159 esophageal carcinoma patients between August 2010 and August 2013 in a crosssectional, descriptive study. Patient characteristics, tumor and treatment details, psychological status, adverse effects, and dietary intake were evaluated at baseline and during radiotherapy. A multivariate logistic regression analyss was performed to identify the potential factors leading to weight loss. Results: 64 (40.3%) patients had weight loss ${\geq}5%$ during radiotherapy. According to logistic regression analysis, depression, esophagitis, and loss of appetite were adverse factors linked to weight loss. Dietary counseling, early stage disease and total energy intake ${\geq}1441.3$ (kcal/d) were protective factors. Conclusions It was found that dietary counseling, TNM stage, total energy intake, depression, esophagitis, and loss of appetite were the most important factors for weight loss. The results underline the importance of maintaining energy intake and providing dietary advice in EC patients during RT. At the same time, by identifying associated factors, medical staff can provide appropriate medical care to reduce weight loss. Further studies should determine the effect of these factors on weight loss and propose a predictive model.

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  2. Cachexia in patients with oesophageal cancer vol.13, pp.3, 2015, https://doi.org/10.1038/nrclinonc.2015.200
  3. Oral Glutamine Supplementation Reduces Radiotherapy-induced Esophagitis in Lung Cancer Patients vol.16, pp.1, 2015, https://doi.org/10.7314/APJCP.2015.16.1.53
  4. Prediction model of critical weight loss in cancer patients during particle therapy pp.1465-3621, 2018, https://doi.org/10.1093/jjco/hyx145
  5. The Prediction of Deterioration of Nutritional Status during Chemoradiation Therapy in Patients with Esophageal Cancer vol.70, pp.2, 2018, https://doi.org/10.1080/01635581.2018.1412481
  6. Enteral Nutrition Support Does Not Improve PNI in Radiotherapy Patients with Locally Advanced Esophageal Cancer pp.1532-7914, 2019, https://doi.org/10.1080/01635581.2018.1559939