Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Glutathione-S-Transferase Polymorphisms (GSTM1, GSTT1 and GSTP1) and Acute Leukemia Risk in Asians: a Meta-analysis

  • Tang, Zhen-Hai (Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University) ;
  • Zhang, Chi (Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University) ;
  • Cheng, Pan (Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University) ;
  • Sun, Hong-Min (Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University) ;
  • Jin, Yu (Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University) ;
  • Chen, Yuan-Jing (Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University) ;
  • Huang, Fen (Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University)
  • Published : 2014.03.01
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Abstract

The association between glutathione-S-transferase polymorphisms (GSTM1, GSTT1 and GSTP1) and risk of acute leukemia in Asians remains controversial. This study was therefore designed to evaluate the precise association in 23 studies identified by a search of PubMed and several other databases, up to December 2013. Using random or fixed effects models odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were calculated. Heterogeneity across studies was assessed, and funnel plots were constructed to test for publication bias. The meta-analysis showed positive associations between GST polymorphisms (GSTM1 and GSTT1 but not GSTP1) and acute leukemia risk [(OR=1.47, 95% CI 1.18-1.83); (OR=1.32, 95% CI 1.07-1.62); (OR=1.01, 95% CI 0.84-1.23), respectively] and heterogeneity between the studies. The results suggested that the GSTM1 null genotype and GSTT1null genotype, but not the GSTP1 polymorphism, might be a potential risk factors for acute leukemia. Further well-designed studies are needed to confirm our findings.

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References

  1. Alves S, Amorim A, Ferreira F, Norton L, Prata MJ (2002). The GSTM1 and GSTT1 genetic polymorphisms and susceptibility to acute lymphoblastic leukemia in children from north Portugal. Leukemia, 16, 1565-7. https://doi.org/10.1038/sj.leu.2402543
  2. Arruda VR, Lima CS, Grignoli CR, et al (2001). Increased risk for acute myeloid leukaemia in individuals with glutathione S-transferase mu 1 (GSTM1) and theta 1 (GSTT1) gene defects. Eur J Haematol, 66, 383-388. https://doi.org/10.1034/j.1600-0609.2001.066006383.x
  3. Aydin-Sayitoglu M, Hatirnaz O, Erensoy N, Ozbek U (2006). Role of CYP2D6, CYP1A1, CYP2E1, GSTT1, and GSTM1 genes in the susceptibility to acute leukemias. Am J Hematol, 81, 162-70. https://doi.org/10.1002/ajh.20434
  4. Balta G, Yuksek N, Ozyurek E, et al (2003). Characterization of MTHFR, GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes in childhood acute leukemia. Am J Hematol, 73, 154-60. https://doi.org/10.1002/ajh.10339
  5. Begg CB, Mazumdar M (1994). Operating characteristics of a rank correlation test for publication bias. Biometrics, 50, 1088-1101. https://doi.org/10.2307/2533446
  6. Bonaventure A, Goujon-Bellec S, Rudant J, et al (2012). Maternal smoking during pregnancy, genetic polymorphisms of metabolic enzymes, and childhood acute leukemia: the ESCALE study (SFCE). Cancer Causes Control, 23, 329-45. https://doi.org/10.1007/s10552-011-9882-9
  7. Chan JY, Ugrasena DG, Lum DW, Lu Y, Yeoh AE (2011). Xenobiotic and folate pathway gene polymorphisms and risk of childhood acute lymphoblastic leukaemia in Javanese children. Hematol Oncol, 29, 116-23. https://doi.org/10.1002/hon.965
  8. Chauhan PS, Ihsan R, Yadav DS, et al (2011). Association of glutathione S-transferase, EPHX, and p53 codon 72 gene polymorphisms with adult acute myeloid leukemia. DNA Cell Biol, 30, 39-46. https://doi.org/10.1089/dna.2010.1092
  9. Das P, Shaik AP, Bammidi VK (2009). Meta-analysis study of glutathione-S-transferases (GSTM1, GSTP1, and GSTT1) gene polymorphisms and risk of acute myeloid leukemia. Leuk Lymphoma, 50, 1345-51. https://doi.org/10.1080/10428190903003236
  10. DerSimonian, R., Laird, N (1986). Meta-analysis in clinical trials. Control Clin Trials, 7, 177-88. https://doi.org/10.1016/0197-2456(86)90046-2
  11. Deschler B, Lubbert M (2006). Acute myeloid leukemia: epidemiology and etiology. Cancer, 107, 2099-2107. https://doi.org/10.1002/cncr.22233
  12. Dunna NR, Vure S, Sailaja K, et al (2013). Deletion of GSTM1 and T1 genes as a risk factor for development of acute leukemia. Asian Pac J Cancer Prev, 14, 2221-4. https://doi.org/10.7314/APJCP.2013.14.4.2221
  13. Dunna NR, Vuree S, Kagita S, et al (2012). Association of GSTP1 gene (I105V) polymorphism with acute leukaemia. J Genet, 91, e60-3.
  14. Egger M, Davey Smith G, Schneider M, Minder C (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315, 629-63. https://doi.org/10.1136/bmj.315.7109.629
  15. Feng JF, Wang J, Zhang L, Yi B, Wang H (2004). [Analysis on GSTM1, T1 genetic polymorphisms in children with AML]. Laboratory Medicine, 3, 260-262.
  16. Gatedee J, Pakakassama S, Muangman S, Pongstaporn W (2007). Glutathione S-transferase P1 genotypes, genetic susceptibility and outcome of therapy in thai childhood acute lymphoblastic leukemia. Asian Pac J Cancer Prev, 8, 294-6.
  17. Haranatha RP, Jamil K (2006). Polymorphisms in the GST (M1 andT1) gene and their possible association with susceptibility tochildhood acute lymphocytic leukemia in Indian population. African Journal of Biotechnology, 5, 1454-1456.
  18. Higgins J.P., Thompson, S.G., Deeks, J.J. Altman, D.G. (2003). Measuring inconsistency in meta-analyses. BMJ, 327, 557-560. https://doi.org/10.1136/bmj.327.7414.557
  19. Jiang LJ, Chen M, Tan GF (2008). The association between polymorphism of cytochrome P4501A1 and glutathione S-transferase M1, T1 genes and acute lymphoblastic leukemia. JYoujiang Medical College for Nationalities, 5, 721-3 (in Chinese).
  20. Jiang LJ, Tan GF (2010). [The association between polymorphism of cytochrome P4501A1 and glutathione S-transferase M1, T1 genes and acute lymphoblastic leukemia]. Chinese Journal of New Clinical Medicine, 3, 810-13.
  21. Joseph T, Kusumakumary P, Chacko P, Abraham A, Radhakrishna Pillai M (2004). Genetic polymorphism of CYP1A1, CYP2D6, GSTM1 and GSTT1 and susceptibility to acute lymphoblastic leukaemia in Indian children. Pediatr Blood Cancer, 43, 560-7. https://doi.org/10.1002/pbc.20074
  22. Kim HN, Kim NY, Yu L, et al (2012). Association of GSTT1 polymorphism with acute myeloid leukemia risk is dependent on smoking status. Leuk Lymphoma, 53, 681-7. https://doi.org/10.3109/10428194.2011.625576
  23. Li YH, Wen FQ, Xiao ZH, et al. (2012). Genetic polymorphism of GST gene in children with infectious mononucleosis and acute lymphoblastic leukemia. Chin J Contemp Pediatr, 4, 260-63.
  24. Liu QX, Chen HC, Liu XF, et al. (2005). Study on the relationship between polymorphisms of CYP1A1, GSTM1, GSTT1 genes and the susceptibility to acute leukemia in the general population of Hunan province. Chin J Epidemiol, 12, 975-79 (in Chinese).
  25. Lohmueller KE, Pearce CL, Pike M, Lander ES, Hirschhorn JN (2003). Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet, 33, 177-82. https://doi.org/10.1038/ng1071
  26. Majumdar S, Mondal BC, Ghosh M, et al (2008). Association of cytochrome P450, glutathione S-transferase and N-acetyl transferase 2 gene polymorphisms with incidence of acute myeloid leukemia. Eur J Cancer Prev, 17, 125-32. https://doi.org/10.1097/CEJ.0b013e3282b6fd68
  27. Mantel, N., Haenszel, W (1959). Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst, 22, 719-48.
  28. Naoe T, Takeyama K, Yokozawa T, et al (2000). Analysis of genetic polymorphism in NQO1, GST-M1, GST-T1, and CYP3A4 in 469 Japanese patients with therapy-related leukemia/ myelodysplastic syndrome and de novo acute myeloid leukemia. Clin Cancer Res, 6, 4091-5.
  29. Ntais C, Polycarpou A, Ioannidis JP (2005). Association of GSTM1, GSTT1 and GSTP1 gene polymorphisms with the risk of prostate cancer: A meta-analysis. Cancer Epidemiol Biomarkers Prev, 14, 176-81.
  30. Sasai Y, Horiike S, Misawa S, et al (1999). Genotype of glutathione S-transferase and other genetic configurations in myelodysplasia. Leuk Res, 23, 975-81. https://doi.org/10.1016/S0145-2126(99)00119-8
  31. Sundberg K, Johansson AS, Stenberg G, et al (1998). Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons. Carcinogenesis, 19, 433-6. https://doi.org/10.1093/carcin/19.3.433
  32. Suneetha KJ, Nancy KN, Rajalekshmy KR, et al. (2011). Role of glutathione-s-transferase and CYP1A1*2A polymorphisms in the therapy outcome of south Indian acute lymphoblastic leukemia patients. Indian J Med Paediatr Oncol, 32, 25-9. https://doi.org/10.4103/0971-5851.81886
  33. Suneetha KJ, Nancy KN, Rajalekshmy KR, Sagar TG, Rajkumar T (2008). Role of GSTM1 (Present/Null) and GSTP1 (Ile105Val) polymorphisms in susceptibility to acute lymphoblastic leukemia among the South Indian population. Asian Pac J Cancer Prev, 9, 733-6.
  34. Tang Q, Li J, Zhang S, et al (2013). GSTM1 and GSTT1 null polymorphisms and childhood acute leukemia risk: evidence from 26 case-control studies. PLoS One, 8, e78810. https://doi.org/10.1371/journal.pone.0078810
  35. Wang J, Zhang L, Feng JF, et la (2004). Genetic polymorphisms analysis of Glutathione s-transferase m1 and ti in children with acute lymphoblastic leukemia. JHuazhong University of Science and Technology [Med Sci], 24, 243-4 (in Chinese). https://doi.org/10.1007/BF02832001
  36. Wong O, Harris F, Armstrong TW, Hua F (2010). A hospitalbased case-control study of acute myeloid leukemia in Shanghai: analysis of environmental and occupational risk factors by subtypes of the WHO classification. Chem Biol Interact, 184, 112-28. https://doi.org/10.1016/j.cbi.2009.10.017
  37. Xu LY, Cao LF (2013). GSTT1 genetic polymorphism and susceptibility to childhood acute lymphoblastic leukemia: a meta-analysis. Tumour Biol, [Epub ahead of print].
  38. Ye Z, Song H (2005). Glutathione s-transferase polymorphisms (GSTM1, GSTP1 and GSTT1) and the risk of acute leukaemia: a systematic review and meta-analysis. Eur J Cancer, 41, 980-9. https://doi.org/10.1016/j.ejca.2005.01.014
  39. Yuan XJ, Gu LJ, Xue HL, et al (2003). Analysis on GSTP genetic polymorphism in children with acute leukemia. Natl Med J China, 21, 1863-66 (in Chinese).
  40. Zhang L, Zhang XX, Wang J (2003). Glutathione S-transferase M1, T1 genetic polymorphisms in childhood leukemia Zhengzhou University ??.
  41. Zhou L, Zhu YY, Zhang XD, Li Y, Liu ZG (2013). Risk effects of GST gene polymorphisms in patients with acute myeloid leukemia: a prospective study. Asian Pac J Cancer Prev, 14, 3861-4. https://doi.org/10.7314/APJCP.2013.14.6.3861
  42. Zou LL, Lin GF, Ma QW, Zhang DS, Shen JH (2004). Glutathione S-transferase T1, M1 genetic polymorphisms in leukemia patients in Shanghai area. Chin J Oncol, 11, 649-51 (in Chinese).

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