Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Fructus Piperis Longi Extracts on Glucose Uptake in Adipocyte

필발 추출물의 포도당 흡수능에 대한 효과

  • Kim, Mi Seong (Center for Metabolic Function Regulation, Wonkwang University School of Medicine) ;
  • Kwon, Kang Beom (Center for Metabolic Function Regulation, Wonkwang University School of Medicine) ;
  • Song, Je Ho (Department of Sports Industry & Welfare, College of Natural Science, Wonkwang University)
  • 김미성 (원광대학교 의과대학 대사기능제어 연구센터) ;
  • 권강범 (원광대학교 의과대학 대사기능제어 연구센터) ;
  • 송제호 (원광대학교 자연과학대학 스포츠산업복지학과)
  • Received : 2013.12.30
  • Accepted : 2014.02.09
  • Published : 2014.02.25
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Abstract

Glucose uptake plays a pivotal role in maintaining whole body glucose homeostasis in adipocytes and skeletal muscles. In the present study we have shown that Fructus Piperis Longi Extracts (FPLE) can stimulate glucose uptake in OP9 adipocytes. The increasing effects of FPLE on glucose uptake were inhibited by compound C pretreatment, which means that the glucose uptake effects by FPLE were carried out by AMP-activated protein kinase (AMPK) activation. Further studies revealed that FPLE stimulated glucose transport occurs through a mechanism involving extracellular signal-regulated kinase (ERK1/2) activation.

Keywords

References

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