Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Case of Suspected Drug-Induced Liver Injury after Intravenous Wild Ginseng Pharmacopuncture

산삼약침 시술 후 발생한 것으로 의심되는 약인성 간손상 : 증례 보고

  • Received : 2013.10.23
  • Accepted : 2014.01.28
  • Published : 2014.02.25
Download PDF
⟨ Previous Next ⟩

Abstract

Wild ginseng pharmacopuncture is a partly used Traditional Korean Medicine's therapy with no previously well documented hepatotoxicity. We report the the first case of suspected drug-induced liver injury (DILI) after intravenous Wild ginseng Pharmacopuncture therapy. Our clinical observation based on patient's laboratory studies, medical history, detailed drug history and ruling out other possible causes. Our patient's suspected diagnosis was wild ginseng pharmacopuncture-induced liver injury with correlation between detailed drug history and laboratory studies. This diagnosis was supported by the Council for International Organizations of Medical Sciences-Roussel Uclaf Causality Assessment Method(RUCAM). This report represents the first documented cases of suspected DILI after intravenous wild ginseng pharmacopuncture therapy, highlighting the need for future research regarding potential hepatotoxicity of Wild ginseng Pharmacopuncture.

Keywords

References

  1. Lazarou, J., Pomeranz, B.H., Corey, P.N. Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. JAMA 279(15):1200-1205, 1998. https://doi.org/10.1001/jama.279.15.1200
  2. Kim, K.A. Current status of liver diseases in Korea: Toxic and alcoholic liver diseases. Korean J Hepatol 15(Suppl 6):29-33, 2009. https://doi.org/10.3350/kjhep.2009.15.S6.S29
  3. Kim, Y.J., Park, D.I., Kwon, K.R. Case report on the Improvement of Liver Functions by Mountain Cultivated Wild Ginseng Pharmacopuncture. J of KPI. 12(2):107-112, 2009.
  4. Kwon, K.R., Park, C.W., La, M.S., Cho, J.K. Clinical Observation of Multiple Metastatic Cancer Patient with Hepatocellular Carcinoma treated with Cultivated Wild Ginseng Herbal Acupucnture Therapy. J of Korean Acupuncture & Moxibustion Society 22(2):211-217, 2005.
  5. Stickel, F., Patsenker, E., Schuppan, D. Herbal hepatotoxicity. J Hepatol. 43(5):901-910, 2005. https://doi.org/10.1016/j.jhep.2005.08.002
  6. Kim, D.J. Toxic hepatitis induced by various plant preparations and healthy foods. Seoul, National Institute of Toxicological Research. 2003.
  7. Jang, I.S. A Review on the Report about Drug-induced Hepatitis published by the National Institute of Toxicological Research. J Korean Oriental Med 25(3):78-89, 2004.
  8. Ahn, B.M. Do Natural Health Products Cause Toxic Hepatitis? J Korean Med Assoc 48(5):448-455, 2005. https://doi.org/10.5124/jkma.2005.48.5.448
  9. Lee, W.M, Senior JR. Recognizing drug-induced liver injury: current problems, possible solutions. Toxicol Pathol 33(1):155-164, 2005. https://doi.org/10.1080/01926230590522356
  10. Kim, D.J. The Assessment of Toxic Liver Injury. Korean J Gastroenterol 53: 5-14, 2009.
  11. Danan, G., Benichou, C. Causality assessment of adverse reactions to drugs - I. A novel method based on the conclusions of international consensus meetings; applications to drug induced liver injuries. J Clin Epidemol 46(11):1323-1330, 1993. https://doi.org/10.1016/0895-4356(93)90101-6
  12. Maria, V.A., Victorino, R.M. Development and validation of a clinical scale for the diagnosis of drug-induced hepatitis. Hepatology 26(3):664-669, 1997. https://doi.org/10.1002/hep.510260319
  13. Lucena, M.I., Camargo, R., Andrade, R.J., Perez-Sanchez, C.J., Sanchez, De La Cuesta F. Comparison of two clinical scales for causality assessment in hepatotoxicity. Hepatology 33(1):123-130, 2001. https://doi.org/10.1053/jhep.2001.20645
  14. Kwon, K.R. A Clinical Study on the Effects of Intravenous Wild ginseng Herbal Acupuncture on the Human Body. J of KPI 7(1):15-22, 2004.
  15. Miller, L.G. Herbal medicinals. Selected clinical considerations focusing on known or potential drug-herb interactions. Arch Intern Med 158: 2200-2211, 1998. https://doi.org/10.1001/archinte.158.20.2200
  16. Posadzki, P., Watson, L., Ernst, E. Herb-drug interactions: an overview of systematic reviews. Br J Clin Pharmacol 75(3):603-618, 2013.