The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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Chronic Non-Social Stress Affects Depressive Behaviors But Not Anxiety in Mice

  • Yoon, Sang Ho (Department of Physiology, Seoul National University College of Medicine) ;
  • Kim, Byung-Hak (Department of Pharmacology, Seoul National University College of Medicine) ;
  • Ye, Sang-Kyu (Department of Pharmacology, Seoul National University College of Medicine) ;
  • Kim, Myoung-Hwan (Department of Physiology, Seoul National University College of Medicine)
  • Received : 2014.03.26
  • Accepted : 2014.04.15
  • Published : 2014.06.30
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Abstract

The etiology of most psychiatric disorders is still incompletely understood. However, growing evidence suggests that stress is a potent environmental risk factor for depression and anxiety. In rodents, various stress paradigms have been developed, but psychosocial stress paradigms have received more attention than non-social stress paradigms because psychosocial stress is more prevalent in humans. Interestingly, some recent studies suggest that chronic psychosocial stress and social isolation affects mainly anxiety-related behaviors in mice. However, it is unclear whether chronic non-social stress induces both depression- and anxiety-related phenotypes or induces one specific phenotype in mice. In the present study, we examined the behavioral consequences of three chronic non-social stress paradigms: chronic predictable (restraint) stress (CPS), chronic unpredictable stress (CUS), and repeated corticosterone-HBC complex injection (RCI). Each of the three paradigms induced mild to severe depression/despair-like behaviors in mice and resulted in increased immobility in a tail suspension test. However, anxiety-related phenotypes, thigmotaxis and explorative behaviors, were not changed by the three paradigms. These results suggest that depression- and anxiety-related phenotypes can be dissociated in mouse stress models and that social and non-social stressors might affect brain circuits and behaviors differently.

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