Asian Pacific Journal of Cancer Prevention

  • 제15권10호
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  • Pages.4129-4133
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  • 2014
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Immune and Anti-oxidant Functions of Ethanol Extracts of Scutellaria baicalensis Georgi in Mice Bearing U14 Cervical Cancers

  • Peng, Yong (Department of Biomedical Engineering, College of Electrical Engineering, Yanshan University) ;
  • Guo, Cong-Shan (Department of Biomedical Engineering, College of Electrical Engineering, Yanshan University) ;
  • Li, Pan-Xia (Department of Biomedical Engineering, College of Electrical Engineering, Yanshan University) ;
  • Fu, Zhan-Zhao (Department of Oncology, the First Hospital of Qinhuangdao City) ;
  • Gao, Li-Ming (Department of Oncology, the First Hospital of Qinhuangdao City) ;
  • Di, Ya (Department of Oncology, the First Hospital of Qinhuangdao City) ;
  • Ju, Ya-Kun (Department of Biomedical Engineering, College of Electrical Engineering, Yanshan University) ;
  • Tian, Ru (Department of Biomedical Engineering, College of Electrical Engineering, Yanshan University) ;
  • Xue, Jia-Jia (Department of Biomedical Engineering, College of Electrical Engineering, Yanshan University)
  • 발행 : 2014.05.30
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초록

Background: The objective was to study the effect of Scutellaria baicalensis Georgi ethanol extracts (SBGE) on immune and anti-oxidant function in U14 tumor-bearing mice. Materials and Methods: U14 tumor-bearing mice were randomly divided into eight groups: a control group, a cyclophosphamide (CTX) group, three dose groups of SBGEI (high, medium, low), and three dose groups of SBGEII (high, medium, low). After two weeks, the thymus and spleen weight indices of mice bearing U14 cervical cancer were calculated. Enzyme linked immunosorbent assays (ELISA) was used to determine the levels of serum IL-2, TNF-${\alpha}$, IL-8, and PCNA. MDA activity and SOD activity in plasma were measured with detection kits. Results: In the SBGE groups, thymus weight and spleen weight indices of U14 tumor-bearing mice were significantly higher than in the control group or CTX group (p<0.05). Compared to control group, the levels of serum IL-2 and TNF-${\alpha}$ in U14 tumor-bearing mice increased significantly, whereas the contents of serum IL-8 and PCNA decreased (p<0.05). The activity of SOD increased with the growing dose of SBGE, while the activity of MDA decreased significantly in the highe-rdose groups of SBGE. Conclusions: These findings suggested that SBGE, especially at high dose, 1000 mg/kg, showed significant immune and anti-oxidant effects infU14 tumor-bearing mice, which might be the mechanisms of SBGE inhibition of tumor growth.

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  2. Synergistic cytotoxic effects of a combined treatment of a Pinellia pedatisecta lipid-soluble extract and cisplatin on human cervical carcinoma in vivo vol.13, pp.6, 2017, https://doi.org/10.3892/ol.2017.6091
  3. MicroRNA-92a promotes tumor growth and suppresses immune function through activation of MAPK/ERK signaling pathway by inhibiting PTEN in mice bearing U14 cervical cancer vol.7, pp.7, 2018, https://doi.org/10.1002/cam4.1329