Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Anti-Depressive Effects of OnDam-Tang with Addition of Linderae Radix (ODT-L) after Chronic Immobilization Stress in C57BL/6 Mice

우울증 유발 생쥐에서 온담탕가오약(溫膽湯加烏藥)의 항우울 효과

  • Lee, Eun Hee (Department of Neuropsychiatry, College of Korean Medicine, Daejeon University) ;
  • Jung, In Chul (Department of Neuropsychiatry, College of Korean Medicine, Daejeon University)
  • 이은희 (대전대학교 한의과대학 신경정신과학교실) ;
  • 정인철 (대전대학교 한의과대학 신경정신과학교실)
  • Received : 2014.05.29
  • Accepted : 2014.08.12
  • Published : 2014.08.25
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Abstract

The purpose of this study was to examine the anti-depressive effects of OnDam-Tang with addition of Linderae Radix (ODT-L) on the animal model of depression induced by chronic immobilization stress. Depression model was made by chronic immobilization stress for 2 hours for 21 days. And we performed forced swimming test, analysis of the neurotransmitter and immunohistochemical staining, measured expression levels of serotonin in the brain. ODT-L has decreased immobilization time in forced swimming test. ODT-L has increased amount of melatonin in the brain. ODT-L has increased expression levels of serotonin in the brain. ODT-L prevented damage in the hippocampal region. ODT-L has reduced the expression level of CRF receptors in in hippocampus region. These results suggest that ODT-L may have anti-depressive effects on depression.

Keywords

References

  1. The Textbook Compliation Committee of Neuropshychiatry of Oriental Schools in Nation. The Neuropsychiatry of Oriental Medicine. Seoul, Jipmoon-Dang, pp 472-475, 477-478, 2007.
  2. Keller, M.B., Bolland, R.J. Implications of failing to achieve successful long-term maintenance treatment of recurrent unipolar major depressoion. Biological Psychiatry 44: 348-360, 1998. https://doi.org/10.1016/S0006-3223(98)00110-3
  3. Greenberg, P.E., Kessler, R., Birnbaum, H.G., Leong, S.A., Lowe, S.W., Berglund, P.A. The economic burden of depression in the United States: How did it change between 1990 and 2000. J Clin Psychiatry 64: 1465-1475, 2003. https://doi.org/10.4088/JCP.v64n1211
  4. Ministry for Health, Welfare and Family Affairs. The Epidemiological Survey of Mental Disorders in Korea, 2011.
  5. Choi, E.M., Koo, S.J. Possibility of regulation by food in depression and mood disorders. Food science and industry, 34(4):53-69, 2001.
  6. Lee, S.H., Kim, B.Y., Kee, J.I., Kwen, S.J., Chung, D.K. A case of Mixed anxiety and depressive disorder. Journal of oriental neuropsychiatry 14(2):127-134, 2003.
  7. Kang, H.W., Jang, H.H., Kang, I.S., Moon, H.C., Hwang, Y.J., Lyu, Y.S. A Study on The Oriental-medical Understanding of Depression. Journal of oriental neuropsychiatry, 12(2):1-15, 2011.
  8. Som, S.M. Bigeub cheon geum yo bang. Seoul, Daeseong munhwasa, p 217, 1984.
  9. Seo, S.H., Jung, I.C., Lee, S.R. The Literature Study of Ondamtng, Guibitang, Soyosan & Their Gagambang Recording in Dong-Eui-Bo-Gam. Journal of institute of oriental medicine, Daejeon univ. 14(1):129-140, 2005.
  10. Heo, J. Dong ui bo gam. Seoul, Beob-in munhwasa, p 238, 303, 428, 2005.
  11. Eom, S.H. Experimental Study on the Effect of the Administration of Gamiondamtang on the Sleep Time. Master's Thesis of Graduate School of Kyunghee University, 1983.
  12. Kim, C.D. Studies on Central Nervous Depressive Action of Ondam Tang Aqueous Extracts. Korean J Pharmacogn 12(1):66, 1981.
  13. Kang, T.L. Effect of Gami-Ondamtang(GO) on brain neuronal transmitters in immobilized rats. Korean journal of oriental preventive medical society 5(2):114-121, 2001.
  14. Kim, D.P., Choi, Y.S., Park, Y.H., Keum, D.H. A Case Report by Heart Rate Variability on the Patient with Dysfunction of Autonom ic Nervous System. Journal of oriental rehabilitation medicine 14(3):173-185, 2004.
  15. Lim, J.M., Moon, B.S., Kim, S.G. Effects of Ondamtang Water Extract on the Heart Function. The Journal of Traditional Korean Medicine 3: 99-113, 1993.
  16. Seol, S.H., Lee, S.R., Jung, I.C. The Effects of OnDam-tang-Kami-bang (ODK) in Antioxidant and Serotonin Metabolism Testing on P815 Cell. Journal of oriental neuropsychiatry 24(2):189-200, 2013. https://doi.org/10.7231/jon.2013.24.2.189
  17. Ju, Y.S. Ungok Herbology. Jeonju, Woosuk Press, p 827, 2013.
  18. Voorhees, J.L., Tarr, A.J., Wohleb, E.S., Godbout, J.P., Mo, X., Sheridan, J.F., Eubank, T.D., Marsh, C.B. Prolonged Restraint Stress Increases IL-6, Reduces IL-10, and Causes Persistent Depressive-Like Behavior That Is Reversed by Recombinant IL-10. PLoS ONE 8(3):1-11, 2013.
  19. Rodrigues, A.L., da Silva, G.L., Mateussi, A.S., Fernandes, E.S., Miguel, O.G., Yunes, R.A., Calixto, J.B., Santos, A.R. Involvement of monoaminergic system in the antidepressant-like effect of the hydroalcoholic extract of Siphocampylus verticillatus. Life sciences 70(12):1347-1358, 2002. https://doi.org/10.1016/S0024-3205(01)01498-9
  20. Cryan, J.F., McGrath, C., Leonard, B.E., Norman, T.R. Combining Pindolol and Paroxetine in an Animal Model of Chronic Antidepressant Action. Can Early Onset of Action Be Detected? Eur J Pharmacol 352: 23-28, 1998. https://doi.org/10.1016/S0014-2999(98)00402-6
  21. Kang, S.S. Baleun Bangjehag. Seoul, Daeseong munhwasa, p 128, 1996.
  22. Lucki, I. The spectrum of behaviors influenced by serotonin. Biol Psychiatry 44: 151-162, 1998. https://doi.org/10.1016/S0006-3223(98)00139-5
  23. Lee, H.S. Clinical Neuropsycopharmacology. Seoul, MLcommunication, 2009.
  24. Koob, G.F. Corticotropin-releasing factor, Norepinephrine, and stress. Biol Psychiatry 46: 1167-1180, 1999. https://doi.org/10.1016/S0006-3223(99)00164-X
  25. Arborelius, L., Owens, M.J., Plotsky, P.M., Nemeroff, C.B. The role of corticotropin-releasing factor in depression and anxiety disorders. J Endocrin 160: 1-12, 1999. https://doi.org/10.1677/joe.0.1600001
  26. Lee, K.W., Kang, S.K., Chun, Y.H., Hong, J.P. The Effect of Repeated Restraint Stress on Clusterin Change of the Rat Salivary Glands. The Journal of Korean Academy of Oral Medicine 37(2):81-91, 2012.
  27. Ro, S.K. The Effect of Binding Stressed White Rats by Chijashitang and Chijashitang+Bambusea Caulis. Dept of Neuropsychiatry Graduate School Kyungsan University pp 1-36, 1995.
  28. Yun, H.Y. Bupleurum Falcatum Prevents Depression Andanxiety-Like Behaviors in the Rats Exposed to Repeated Restraint Stress. Graduate School of Oriental Medicine KyungHee University pp 1-41, 2012.
  29. Woon, F.L., Sood, S., Hedges, D.W. Hippocampal volume deficits associated with exposure to psychological trauma and posttraumatic stress disorder in adults: a meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry 34: 1181-1188, 2010. https://doi.org/10.1016/j.pnpbp.2010.06.016
  30. Nestler, E.J., Barrot, M., DiLeone, R.J., Eisch, A.J., Gold, S.J., Monteggia, L.M. Neurobiology of depression. Neuron 34: 13-25, 2002. https://doi.org/10.1016/S0896-6273(02)00653-0
  31. McKinnon, M.C., Yucel, K., Nazarov, A., MacQueen, G.M.. A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder. J Psychiatry Neurosci 34: 41-54, 2009.
  32. Lee, I.A., Yoganarasimha, D., Rao, G., Knierim, J.J. Comparison of population coherence of place cells in hippocampal subfields CA1 and CA3. Nature 430(6998):456-459, 2004. https://doi.org/10.1038/nature02739