Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Acupuncture for Chemotherapy-induced Peripheral Neuropathy : a Pilot Study

항암화학요법 유발 말초신경병증에 대한 침치료의 효과 : 파일럿 연구

  • 한창우 (부산대학교병원 통합의학센터) ;
  • 황의형 (부산대학교병원 통합의학센터) ;
  • 김효정 (부산대학교병원 혈액종양내과) ;
  • 신호진 (부산대학교병원 혈액종양내과)
  • Received : 2014.06.05
  • Accepted : 2014.07.18
  • Published : 2014.08.25
Download PDF
⟨ Previous Next ⟩

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) which is one of the common chemotherapy related toxicity poses a significant clinical challenge. Here we conducted a prospective pilot study to evaluate the efficacy of acupuncture on CIPN. Patients with CIPN were administered acupuncture procedure with continuation of previous conventional medication. Acupuncture procedures were conducted three times per week for 3 weeks. We assessed patients with Common Terminology Criteria for Adverse Events (CTCAE) v4.0, Visual Analog Scale (VAS), Functional Assessment of Cancer Therapy/Gynecologic Oncology Group Neurotoxicity (FACT/GOG-Ntx) at the time of baseline and every week after the acupuncture procedures. Total 5 patients were included and treated with acupuncture. CTCAE grades were the same of 2 in all patients. VAS mean value changed from 5.2 to 3.2, and FACT/GOG-Ntx total score that suggests the higher relates to better quality of life changed from 93.3 to 110 as mean value at the end of the 3rd week, though this index difference did not show any statistically significant difference. This pilot study suggests that acupuncture procedure may have a role for CIPN treatment. Launching a more larger and properly controlled study will be required to ascertain the efficacy of acupuncture.

Keywords

References

  1. Tofthagen, C.S., McMillan, S.C., Kip, K.E. Development and psychometric evaluation of the chemotherapy-induced peripheral neuropathy assessment tool. Cancer Nurs 34(4):E10-20, 2011.
  2. Hausheer, F.H., Schilsky, R.L., Bain, S., Berghorn, E.J., Lieberman, F. Diagnosis, management, and evaluation of chemotherapy-induced peripheral neuropathy. Semin Oncol 33(1):15-49, 2006.
  3. Postma, T.J., Heimans, J.J. Grading of chemotherapyinduced peripheral neuropathy. Ann Oncol 11(5):509-513, 2000. https://doi.org/10.1023/A:1008345613594
  4. Pachman, D.R., Barton, D.L., Watson, J.C., Loprinzi, C.L. Chemotherapy-induced peripheral neuropathy: prevention and treatment. Clin Pharmacol Ther 90(3):377-387, 2011. https://doi.org/10.1038/clpt.2011.115
  5. 孙伟芬, 李晓峰, 张旭岗, 刘玉, 李毅俊, 李金涛. 补阳还五汤浸洗治疗化疗致周围神经病变30 例. 福建中医药大学学报 20(5):8-9, 2010.
  6. Kim, J.H., Kim, E.J., Seo, B.K., Lee, S., Jung, S.Y., Lee, M.H., Kim, A.R., Park, H.J., Shin, M.S., Choi, S.M. Electroacupuncture for chemotherapy-induced peripheral neuropathy: study protocol for a pilot multicentre randomized, patient-assessor-blinded, controlled trial. Trials 14: 254, 2013. https://doi.org/10.1186/1745-6215-14-254
  7. Bao, T., Zhang, R., Badros, A., Lao, L. Acupuncture treatment for bortezomib-induced peripheral neuropathy: a case report. Pain Res Treat 2011: 920807, 2011.
  8. Wong, R., Sagar, S. Acupuncture treatment for chemotherapy-induced peripheral neuropathy--a case series. Acupunct Med 24(2):87-91, 2006. https://doi.org/10.1136/aim.24.2.87
  9. Donald, G.K., Tobin, I., Stringer, J. Evaluation of acupuncture in the management of chemotherapy-induced peripheral neuropathy. Acupunct Med 29(3):230-233, 2011. https://doi.org/10.1136/acupmed.2011.010025
  10. Schroeder, S., Meyer-Hamme, G., Epplee, S. Acupuncture for chemotherapy-induced peripheral neuropathy (CIPN): a pilot study using neurography. Acupunct Med 30(1):4-7, 2012. https://doi.org/10.1136/acupmed-2011-010034
  11. Yoon, J., Jeon, J.H., Lee, Y.W., Cho, C.K., Kwon, K.R., Shin, J.E., Sagar, S., Wong, R., Yoo, H.S. Sweet bee venom pharmacopuncture for chemotherapy-induced peripheral neuropathy. J Acupunct Meridian Stud 5(4):156-165, 2012. https://doi.org/10.1016/j.jams.2012.05.003
  12. Rostock, M., Jaroslawski, K., Guethlin, C., Ludtke, R., Schröder, S., Bartsch, H.H. Chemotherapy-induced peripheral neuropathy in cancer patients: a four-arm randomized trial on the effectiveness of electroacupuncture. Evid Based Complement Alternat Med 2013: 349653, 2013.
  13. National Cancer Institute, NCI Cancer Bulletin. A closer look:chemotherapy-induced peripheral neuropathy. http://www.cancer.gov/aboutnci/ncicancerbulletin/archiv e/2010/022310/page6. [accessed 05.22.14].
  14. Balayssac, D., Ferrier, J., Descoeur, J., Ling, B., Pezet, D., Eschalier, A., Authier, N. Chemotherapy-induced peripheral neuropathies: from clinical relevance to preclinical evidence. Expert Opin Drug Saf 10(3):407-417, 2011. https://doi.org/10.1517/14740338.2011.543417
  15. Peltier, A.C., Russell, J.W. Recent advances in drug-induced neuropathies. Curr Opin Neurol 15(5):633-638, 2002. https://doi.org/10.1097/00019052-200210000-00015
  16. Pike, C.T., Birnbaum, H.G., Muehlenbein, C.E., Pohl, G.M., Natale, R.B. Healthcare costs and workloss burden of patients with chemotherapy-associated peripheral neuropathy in breast, ovarian, head and neck, and nonsmall cell lung cancer. Chemother Res Pract 2012: 913848, 2012.
  17. Windebank, A.J., Grisold, W. Chemotherapy-induced neuropathy. J Peripher Nerv Syst 13(1):27-46, 2008. https://doi.org/10.1111/j.1529-8027.2008.00156.x
  18. Kaley, T.J., Deangelis, L.M. Therapy of chemotherapyinduced peripheral neuropathy. Br J Haematol 145(1):3-14, 2009. https://doi.org/10.1111/j.1365-2141.2008.07558.x