Asian Pacific Journal of Cancer Prevention

  • 제15권16호
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  • Pages.6495-6497
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  • 2014
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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TRAIL Based Therapy: Overview of Mesenchymal Stem Cell Based Delivery and miRNA Controlled Expression of TRAIL

  • Attar, Rukset (Department of Obstetrics and Gynecology, Yeditepe University Hospital) ;
  • Sajjad, Farhana (Department of Anatomy, Allama Iqbal Medical College) ;
  • Qureshi, Muhammad Zahid (Department of Chemistry, GCU) ;
  • Tahir, Fizza (Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College) ;
  • Hussain, Ejaz (Department of Botany, GCU) ;
  • Fayyaz, Sundas (Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College) ;
  • Farooqi, Ammad Ahmad (Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College)
  • 발행 : 2014.08.30
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초록

Rapidly increasing number of outstanding developments in the field of TRAIL mediated signaling have revolutionized our current information about inducing and maximizing TRAIL mediated apoptosis in resistant cancer cells. Data obtained with high-throughput technologies have provided finer resolution of tumor biology and now it is known that a complex structure containing malignant cells strictly coupled with a large variety of surrounding cells constitutes the tumor stroma. Utility of mesenchymal stem cells (MSCs) as cellular vehicles has added new layers of information. There is sufficient experimental evidence substantiating efficient gene deliveries into MSCs by retroviral, lentiviral and adenoviral vectors. Moreover, there is a paradigm shift in molecular oncology and recent high impact research has shown controlled expression of TRAIL in cancer cells on insertion of complementary sequences for frequently downregulated miRNAs. In this review we have attempted to provide an overview of utility of TRAIL engineered MSCs for effective killing of tumor and potential of using miRNA response elements as rheostat like switch to control expression of TRAIL in cancer cells.

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참고문헌

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  2. Opposite Effects of Coinjection and Distant Injection of Mesenchymal Stem Cells on Breast Tumor Cell Growth vol.5, pp.9, 2016, https://doi.org/10.5966/sctm.2015-0300
  3. Co-culture with lung cancer A549 cells promotes the proliferation and migration of mesenchymal stem cells derived from bone marrow vol.14, pp.4, 2017, https://doi.org/10.3892/etm.2017.4909
  4. The Use of Normal Stem Cells and Cancer Stem Cells for Potential Anti-Cancer Therapeutic Strategy vol.15, pp.4, 2018, https://doi.org/10.1007/s13770-018-0128-8