Asian Pacific Journal of Cancer Prevention

  • 제15권16호
  • /
  • Pages.6745-6748
  • /
  • 2014
  • /
  • 1513-7368(pISSN)
  • /
  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
권호 표지
DOI QR코드

DOI QR Code

C13orf18 and C1orf166 (MULAN) DNA Genes Methylation are Not Associated with Cervical Cancer and Precancerous Lesions of Human Papillomavirus Genotypes in Iranian Women

  • Sohrabi, Amir (Department of Molecular Medicine, School of Advanced Medical Technologies, Tehran University of Medical Sciences) ;
  • Mirab-Samiee, Siamak (Food and Drug Laboratory Research Center, Ministry of Health and Medical Education) ;
  • Rahnamaye-Farzami, Marjan (Research Center of Health Reference Laboratory, Ministry of Health and Medical Education) ;
  • Rafizadeh, Mitra (Department of Pathology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences) ;
  • Akhavan, Setareh (Department of Gynecology, Vali-e-asr Hospital, Tehran University of Medical Sciences) ;
  • Hashemi-Bahremani, Mohammad (Department of Pathology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences) ;
  • Modarressi, Mohammad Hossein (Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences)
  • 발행 : 2014.08.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Background: Nowadays, molecular biomarkers have critical roles for cancer diagnosis and prognosis in clinical laboratories. Human papillomaviruses are the main agents for etiology of cervical carcinoma. The present survey was conducted to evaluate the genes methylation in cervical cancer and precancerous lesions involvement with HPV genotypes. Materials and Methods: C13orf18 and C10rf166 (MULl or Mulan) DNA methylation as potential biomarkers and risk factors was investigated in 112 liquid based cytology and Formalin-Fixed Paraffin-Embedded tissue specimens in Iranian females with cervical intraepithelial neoplasia and dysplasia. Results: In this survey, HPV18 (61.6%) and HPV16 (42.9%) proved to be the most common HPV genotypes identified by In-House Multiplex Real Time PCR. There were no significant relationship between HPV positivity and the methylated DNA genes mentioned above (p>0.05). Conclusions: Our MethyLight data demonstrated that these genes could not be considered as specific, sensitive and suitable prognostic biomarkers in cervical dysplasia related HPV. It is suggested that further studies with more patients should be done on candidate methylated markers in different countries in order to plan for cervical cancer prevention.

키워드

참고문헌

  1. Al-Shabanah OA, Hafez MM, Hassan ZK, et al (2014). Methylation of SFRPs and APC Genes in ovarian cancer infected with high risk human papillomavirus. Asian Pac J Cancer Prev,15, 2719-25. https://doi.org/10.7314/APJCP.2014.15.6.2719
  2. Banzai C, Nishino K, Quan J, et al (2013). Promoter methylation of DAPK1, FHIT, MGMT, and CDKN2A genes in cervical carcinoma. Int J Clin Oncol, 19, 127-32.
  3. Clifford GM, Rana RK, Franceschi S, et al (2005). Human papillomavirus genotype distribution in low-grade cervical lesions: comparison by geographic region and with cervical cancer. Cancer Epidemiol Biomarkers Prev, 14, 1157-64. https://doi.org/10.1158/1055-9965.EPI-04-0812
  4. Duenas-Gonzalez A, Lizano M, Candelaria M, et al (2005). Epigenetics of cervical cancer. An overview and therapeutic perspectives. Mol Cancer, 25, 4, 38. https://doi.org/10.1186/1476-4598-4-38
  5. Eijsink JJH, Lendvai A, Deregowski V, et al (2012). Four-gene methylation marker panel as triage test in highrisk human papillomavirus positive patients. Int J Cancer, 130, 1861-9. https://doi.org/10.1002/ijc.26326
  6. Eijsink JJ, Yang N, Lendvai A, et al (2011). Detection of cervical neoplasia by DNA methylation analysis in cervico-vaginal lavages, a feasibility study. Gynecol Oncol, 120, 280-3. https://doi.org/10.1016/j.ygyno.2010.10.029
  7. Hamzi Abdul Raub S, Isa NM, Zailani HA, et al (2013). Distribution of HPV genotypes in cervical cancer in multiethnic Malaysia. Asian Pac J Cancer Prev, 15, 651-6. https://doi.org/10.7314/APJCP.2014.15.2.651
  8. Huisman C, Wisman GB, Kazemier HG, et al (2013). Functional validation of putative tumor suppressor gene C13ORF18 in cervical cancer by artificial transcription factors. Mol Oncol, 7, 669-79. https://doi.org/10.1016/j.molonc.2013.02.017
  9. Hwang SJ, Shroyer KR (2012). Biomarkers of cervical dysplasia and carcinoma. J Oncol, 507286, doi: 10.1155/2012/507286.
  10. Kasamatsu E, Cubilla AL, Alemany L, et al (2012). Type-specific human papillomavirus distribution in invasive cervical carcinomas in paraguay, a study of 432 cases. J Med Virol, 84, 1628-35. https://doi.org/10.1002/jmv.23373
  11. Lan VTT, Thuan TB, Thu DM, et al (2013). Methylation profile of BRCA1, RASSF1A and ER in Vietnamese women with ovarian cancer. Asian Pac J Cancer Prev, 14, 7713-8. https://doi.org/10.7314/APJCP.2013.14.12.7713
  12. Laudadido J (2013). Human papillomavirus detection: testing methodologies and their clinical utility in cervical cancer screening. Adv Anat Pathol, 20, 158-67. https://doi.org/10.1097/PAP.0b013e31828d1893
  13. Lee JH, Lee NW, Hong SW, et al (2011). Establishment of an efficient multiplex real-time PCR assay for human papillomavirus genotyping in cervical cytology specimens: comparison with hybrid capture II. Cytopathology, 22, 261-8. https://doi.org/10.1111/j.1365-2303.2010.00787.x
  14. Li W, Bengtson MH, Ulbrich A, et al (2008). Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling. PLoS One, 3, 1487. https://doi.org/10.1371/journal.pone.0001487
  15. Limpaiboon T (2012) . Epigenet ic aber rat ions i n cholangiocarcinoma: potential biomarkers and promising target for novel therapeutic strategies. Asian Pacific J Cancer Prev, 13, 41-5. https://doi.org/10.7314/APJCP.2012.13.1.041
  16. Ma JQ, Kurban S, Zhao JD, et al (2014). Epigenetic regulation of human riboflavin transporter 2(hRFf2) in cervical cancers from uighur women. Asian Pac J Cancer Prev, 15, 2485-9. https://doi.org/10.7314/APJCP.2014.15.6.2485
  17. Manjari M, Sweta S (2012). Detection of HPV by PCR-a novel step in the prevention of cancer cervix. J Obstet Gynaecol India, 62, 188-91. https://doi.org/10.1007/s13224-012-0167-3
  18. Mohiuddin MK, Chava S, Upendrum P, et al (2013). Role of human papilloma virus infection and altered methylation of specific genes in esophageal cancer. Asian Pac J Cancer Prev, 14, 4187-93. https://doi.org/10.7314/APJCP.2013.14.7.4187
  19. Nogueira da Costa A, Herceg Z (2012). Detection of cancerspecific epigenomic changes in biofluids: powerful tools in biomarker discovery and application. Mol Oncol, 6, 704-15. https://doi.org/10.1016/j.molonc.2012.07.005
  20. Nunobiki O, Ueda M, Toji E, et al (2011). Genetic polymorphism of cancer susceptibility genes and HPV infection in cervical carcinogenesis. Patholog Res Int, 364069, doi: 10.4061/2011/364069.
  21. Othman N, Othman NH (2014). Detection of human papillomavirus DNA in routine cervical scraping samples: use for a national cervical cancer screening program in a developing nation. Asian Pac J Cancer Prev, 15, 2245-9. https://doi.org/10.7314/APJCP.2014.15.5.2245
  22. Snellenberg S, De Strooper LM, Hesselink AT, et al (2012). Development of a multiplex methylation-specific PCR as candidate triage test for women with an HPV-positive cervical scrape. BMC Cancer, 23, 12:551.
  23. Shayanfar N, Hosseini N, Panahi M, et al (2013). Detection of mucosal type human papillomavirus in cutaneous squamous cell carcinoma in Iran. Pathol Res Pract, 209, 90-4. https://doi.org/10.1016/j.prp.2012.10.010
  24. Sun LL, Cao DY, Yang JX, et al (2012). Population-based case- control study on DAPK1, RAR-2 and MGMT methylation in liquid-based cytology. Arch Gynecol Obstet, 285, 1433-9. https://doi.org/10.1007/s00404-011-2149-6
  25. Szalmas A, Konya J (2009). Epigenetic alterations in cervical carcinogenesis. Semin Cancer Biol, 19, 144-52. https://doi.org/10.1016/j.semcancer.2009.02.011
  26. Turki R, Sait K, Anfinan N, et al (2013). Prevalence of human papillomavirus in women from Saudi Arabia. Asian Pac J Cancer Prev, 14, 3177-81. https://doi.org/10.7314/APJCP.2013.14.5.3177
  27. Yang N, Eijsink JJH, Lendvai A, et al (2009). Methylation markers for CCNA1 and C13ORF18 are strongly associated with high-grade cervical intraepithelial neoplasia and cervical cancer in cervical scrapings. Cancer Epidemiol Biomarkers Prev, 18, 3000-7. https://doi.org/10.1158/1055-9965.EPI-09-0405
  28. Wang YY, Li L, Wei S, et al (2013). Human papillomavirus (HPV) infection in women participating in cervical cancer screening from 2006 to 2010 in Shenzhen city, south China. Asian Pac J Cancer Prev, 14, 7483-7. https://doi.org/10.7314/APJCP.2013.14.12.7483
  29. Wang ZM (2014). PAX1 methylation analysis by MS-HRM is useful in triage of high-grade squamous intraepithelial lesions. Asian Pac J Cancer Prev, 15, 891-4. https://doi.org/10.7314/APJCP.2014.15.2.891
  30. Wentzensen N, Sherman ME, Schiffman M, et al (2009). Utility of methylation markers in cervical cancer early detection: Appraisal of the state-of-the-science. Gynecol Oncol, 112, 293-9. https://doi.org/10.1016/j.ygyno.2008.10.012
  31. WHO/ICO HPV Information Centre (2010). Human papillomavirus and related cancers, specific Iran summary report. Available at http://www.who.int/hpvcentre.

피인용 문헌

  1. Characterization of JAK2 V617F (1849 G ＞ T) Mutation in Cervical Cancer Related to Human Papillomavirus and Sexually Transmitted Infections vol.23, pp.2, 2018, https://doi.org/10.15430/JCP.2018.23.2.82