Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Descriptive Epidemiology of Colorectal Cancer in University Malaya Medical Centre, 2001 to 2010

  • Magaji, Bello Arkilla (Julius Centre University of Malaya, Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya) ;
  • Moy, Foong Ming (Julius Centre University of Malaya, Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya) ;
  • Roslani, April Camilla (Department of Surgery, Faculty of Medicine, University of Malaya) ;
  • Law, Chee Wei (Department of Surgery, Faculty of Medicine, University of Malaya)
  • Published : 2014.08.15
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Abstract

Background: Colorectal cancer is the second most frequent cancer in Malaysia. Nevertheless, there is little information on treatment and outcomes nationally. We aimed to determine the demographic, clinical and treatment characteristics of colorectal cancer patients treated at the University Malaya Medical Centre (UMMC) as part of a larger project on survival and quality of life outcomes. Materials and Methods: Medical records of 1,212 patients undergoing treatment in UMMC between January 2001 and December 2010 were reviewed. A retrospective-prospective cohort study design was used. Research tools included the National Cancer Patient Registration form. Statistical analysis included means, standard deviations (SD), proportions, chi square, t-test/ANOVA. P-value significance was set at 0.05. Results: The male: female ratio was 1.2:1. The mean age was 62.1 (SD12.4) years. Patients were predominantly Chinese (67%), then Malays (18%), Indians (13%) and others (2%). Malays were younger than Chinese and Indians (mean age 57 versus 62 versus 62 years, p<0.001). More females (56%) had colon cancers compared to males (44%) (p=0.022). Malays (57%) had more rectal cancer compared to Chinese (45%) and Indians (49%) (p=0.004). Dukes' stage data weres available in 67%, with Dukes' C and D accounting for 64%. Stage was not affected by age, gender, ethnicity or tumor site. Treatment modalities included surgery alone (40%), surgery and chemo/radiotherapy 32%, chemo and radiotherapy (8%) and others (20%). Conclusions: Significant ethnic differences in age and site distribution, if verified in population-based settings, would support implementation of preventive measures targeting those with the greatest need, at the right age.

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References

  1. Amin TT, Suleman W, Al Taissan AA, et al (2012). Patients' profile, clinical presentations and histopathological features of colo-rectal cancer in Al Hassa region, Saudi Arabia. Asian Pac J Cancer Prev, 13, 211-16. https://doi.org/10.7314/APJCP.2012.13.1.211
  2. Chong VH, Abdullah MS, Telisinghe PU, Jalihal A (2009). Colorectal cancer: incidence and trend in Brunei Darussalam. Singapore Med J, 50, 1085-9.
  3. Chou CL, Chang SC, Lin TC, et al (2011). Differences in clinicopathological characteristics of colorectal cancer between younger and elderly patients: an analysis of 322 patients from a single institution. Am J Surg, 202, 574-82. https://doi.org/10.1016/j.amjsurg.2010.10.014
  4. de Kok IM, Wong CS, Chia KS, et al (2008). Gender differences in the trend of colorectal cancer incidence in Singapore, 1968-2002. Int J Colorectal Dis, 23, 461-7. https://doi.org/10.1007/s00384-007-0421-9
  5. Goh KL, Quek KF, Yeo GTS, et al (2005). Colorectal cancer inAsians: a demographic and anatomic survey in Malaysian patients undergoing colonoscopy. Aliment Pharmacol Ther, 22, 859-64 https://doi.org/10.1111/j.1365-2036.2005.02646.x
  6. Hajmanoochehri F, Asefzadeh S, Kazemifar AM, Ebtehaj M (2014). Clinicopathological features of colon adenocarcinoma in Qazvin, Iran: a 16 year study. Asian Pac J Cancer Prev, 15, 951-5. https://doi.org/10.7314/APJCP.2014.15.2.951
  7. Hashim SM, Fah TS, Omar K, et al (2011). Knowledge of colorectal cancer among patients presenting with rectal bleeding and its association with delay in seeking medical advice. Asian Pac J Cancer Prev, 12, 2007-11.
  8. Hashim SM, Omar K, Fah TS, et al (2010). Factors influencing late consultation among patients with rectal bleeding in University Kebangsaan Malaysia Medical Centre. Asian Pac J Cancer Prev, 11, 1335-9.
  9. Hassan MO, Arthurs Z, Sohn VY, Steele SR (2009). Race does not impact colorectal cancer treatment or outcomes with equal access. Am J Surg, 197, 485-90. https://doi.org/10.1016/j.amjsurg.2008.01.017
  10. Hassan MR, Khamizar W, Raihan N, Kiew KK (2010). Incidence of colorectal cancer in Kedah and Perlis, Malaysia. J Gastroenterol Hepatol, 25, 73.
  11. Hassan MRA, Khazim WKW, Mustapha NRN, Othman Z (2011). Features of colorectal cancer in Malaysia. J Gastroenterol Hepatol, 26, 90. https://doi.org/10.1111/j.1440-1746.2010.06480.x
  12. Hyodo I, Suzuki H, Takahashi K, et al (2010). Present status and perspectives of colorectal cancer in Asia: Colorectal Cancer Working Group report in 30th Asia-Pacific Cancer Conference. Jpn J Clin Oncol, 40, 38-43. https://doi.org/10.1093/jjco/hyq125
  13. IARC. Chapter 17 The role of cancer registries (pp. 385-403).
  14. Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  15. King M, Kutty MK (1971). Carcinoma of he stomach, colon, and rectum. A survey of 772 surgical biopsies from Malaya. Br J Surg, 58, 123-6. https://doi.org/10.1002/bjs.1800580211
  16. Kong CK, Roslani AC, Law CW, Law SC, Arumugam K (2010). Impact of socio-economic class on colorectal cancer patient outcomes in Kuala Lumpur and Kuching, Malaysia. Asian Pac J Cancer Prev, 11, 969-74.
  17. Koo JH, Leong RW (2010). Sex differences in epidemiological, clinical and pathological characteristics of colorectal cancer. J Gastroenterol Hepatol, 25, 33-42. https://doi.org/10.1111/j.1440-1746.2009.05992.x
  18. Laiyemo AO, Doubeni C, Pinsky PF, et al (2010). Race and colorectal cancer disparities: health-care utilization vs different cancer susceptibilities. J Natl Cancer Inst, 102, 538-46. https://doi.org/10.1093/jnci/djq068
  19. Law CW, Roslani AC, Ng LL (2009). Treatment delay in rectal cancer. Med J Malaysia, 64, 163-5.
  20. Lim GCC, Halimah Y (2004). The second report of the national cancer registry: cancer incidence in malaysia 2003. kuala lumpur: national cancer registry of Malaysia.
  21. Mosli MH, Al-Ahwal MS (2012). Does the increasing trend of colorectal cancer incidence in Jeddah reflect a rise in the Kingdom of Saudi Arabia? Asian Pac J Cancer Prev, 13, 6285-8. https://doi.org/10.7314/APJCP.2012.13.12.6285
  22. Nadathur SG (2010). Maximising the value of hospital administrative datasets. Aust Health Rev, 34, 216-23. https://doi.org/10.1071/AH09801
  23. Ooi CH, Kayu A, Yao SK, et al (2005). Epidemiology of Cancer in Sarawak 1996-2000. In CH Ooi, A Kayu, S K Yao, B Helli, W Mastulu & J. Assan. (Eds.), (pp. 39). Sarawak: Sarawak Health Department
  24. Pathy S, Lambert R, Sauvaget C, Sankaranarayanan R (2012). The incidence and survival rates of colorectal cancer in India remain low compared with rising rates in East Asia. Dis Colon Rectum, 55, 900-6. https://doi.org/10.1097/DCR.0b013e31825afc4e
  25. Pourhoseingholi MA (2012). Increased burden of colorectal cancer in Asia. World J Gastrointest Oncol, 4, 68-70. https://doi.org/10.4251/wjgo.v4.i4.68
  26. Sabounchi S, Keihanian S, Anand BS (2012). Impact of race on colorectal cancer. Clin Colorectal Cancer, 11, 66-70. https://doi.org/10.1016/j.clcc.2011.03.026
  27. Shah SA, Neoh HM, Rahim SS, et al (2014). Spatial analysis of colorectal cancer cases in Kuala Lumpur. Asian Pac J Cancer Prev, 15, 1149-54. https://doi.org/10.7314/APJCP.2014.15.3.1149
  28. Tsukuma H, Ioka A, Tanaka M (2011). Incidence and mortality of colorectal cancer--international comparison. Nihon Rinsho, 69, 45-50.
  29. Vines JJ, Ardanaz E, Arrazola A, Gaminde I (2003). Populationbased epidemiology of colorectal cancer: causality review. An Sist Sanit Navar, 26, 79-97.
  30. Wendy L, Radzi M (2008). New registry: national cancer patient registry--colorectal cancer. Med J Malaysia, 63, 57-8.
  31. Yahaya DD, Yoong CC, Sulaiman DD, et al (2011). Annual report 2008 Kuala Lumpur: Ministry Of Health Malaysia.
  32. Yee YK, Tan VP, Chan P, et al (2009). Epidemiology of colorectal cancer in Asia. J Gastroenterol Hepatol, 24, 1810-6. https://doi.org/10.1111/j.1440-1746.2009.06138.x
  33. Zainal Ariffin O, Nor Saleha IT (2011). National cancer Registry Report 2007. In O Zainal Ariffin & I. T. N. Saleha (Eds.). Kuala Lumpur: Ministry of Health.
  34. Zarihah MZ, Mohd Yusoff H, Devaraj T, et al (2003). Penang Cancer Registry Report 1994-1998 (P. S. H. Department, Trans.) (Vol. 6, pp. 34). Penang: Penang State Health Department.

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