Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Anti-metastasis Activity of Black Rice Anthocyanins Against Breast Cancer: Analyses Using an ErbB2 Positive Breast Cancer Cell Line and Tumoral Xenograft Model

  • Luo, Li-Ping (Department of Public Health, Chengdu Medical College) ;
  • Han, Bin (Department of Public Health, Chengdu Medical College) ;
  • Yu, Xiao-Ping (Department of Public Health, Chengdu Medical College) ;
  • Chen, Xiang-Yan (Department of Public Health, Chengdu Medical College) ;
  • Zhou, Jie (Department of Public Health, Chengdu Medical College) ;
  • Chen, Wei (Department of Public Health, Chengdu Medical College) ;
  • Zhu, Yan-Feng (Department of Public Health, Chengdu Medical College) ;
  • Peng, Xiao-Li (Department of Public Health, Chengdu Medical College) ;
  • Zou, Qiang (Department of Public Health, Chengdu Medical College) ;
  • Li, Sui-Yan (School of Life Science and Engineering, Southwest Jiaotong University)
  • Published : 2014.08.15
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Abstract

Background: Increasing evidence from animal, epidemiological and clinical investigations suggest that dietary anthocyanins have potential to prevent chronic diseases, including cancers. It is also noteworthy that human epidermal growth factor receptor 2 (ErbB2) protein overexpression or ErbB2 gene amplification has been included as an indicator for metastasis and higher risk of recurrence for breast cancer. Materials and Methods: The present experiments investigated the anti-metastasis effects of black rice anthocyanins (BRACs) on ErbB2 positive breast cancer cells in vivo and in vitro. Results: Oral administration of BRACs (150 mg/kg/day) reduced transplanted tumor growth, inhibited pulmonary metastasis, and decreased lung tumor nodules in BALB/c nude mice bearing ErbB2 positive breast cancer cell MDA-MB-453 xenografts. The capacity for migration, adhesion, motility and invasion was also inhibited by BRACs in MDA-MB-453 cells in a concentration dependent manner, accompanied by decreased activity of a transfer promoting factor, urokinase-type plasminogen activator (u-PA). Conclusions: Together, our results indicated that BRACs possess anti-metastasis potential against ErbB2 positive human breast cancer cells in vivo and in vitro through inhibition of metastasis promoting molecules.

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References

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