Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Outcome of Rectal Cancer in Patients Aged 30 Years or Less in the Pakistani Population

  • Akbar, Ali (Department of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre) ;
  • Bhatti, Abu Bakar Hafeez (Department of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre) ;
  • Khattak, Shahid (Department of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre) ;
  • Syed, Aamir Ali (Department of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre) ;
  • Kazmi, Ather Saeed (Department of Medical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre) ;
  • Jamshed, Aarif (Department of Radiation Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre)
  • Published : 2014.08.15
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Abstract

Background: The incidence of rectal cancer is increasing in younger age groups. Limited data is available regarding survival outcome in younger patients with conflicting results from western world. The goal of this study was to determine survival in patients with rectal cancer <30 years of age and compare it with their older counterparts in the Pakistani population. Materials and Methods: A retrospective chart review of patients operated for rectal adenocarcinoma between January 2005 and December 2010 was performed. Patients were divided into two groups, Group 1 aged ${\leq}30years$ and Group 2 aged >30years. Patient characteristics, surgical procedure, histopathological details and number of loco-regional and distant failures were compared. Expected 5 year survival was calculated using Kaplan Meier curves and significance was determined using the Log rank test. Results: There were 38 patients in group 1 and 144 in group 2. A significantly high number of younger patients presented with poorly differentiated histology (44.7% vs 9.7%) (p=0.0001) and advanced pathological stage (63.1% vs 38.1%) (p=0.04). Predicted overall 5 year survival was 38% versus 57% in groups I and II, respectively (p=0.05). Disease free survival was 37% versus 52% and was significantly different (p=0.007). Conclusions: Early onset rectal cancer is associated with poor pathological features and a worse outcome in Pakistani population.

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References

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