Asian Pacific Journal of Cancer Prevention

  • 제15권15호
  • /
  • Pages.6449-6453
  • /
  • 2014
  • /
  • 1513-7368(pISSN)
  • /
  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
권호 표지
DOI QR코드

DOI QR Code

Albumin-globulin Ratio for Prediction of Long-term Mortality in Lung Adenocarcinoma Patients

  • Duran, Ayse Ocak (Department of Medical Oncology, Faculty of Medicine, Erciyes University) ;
  • Inanc, Mevlude (Department of Medical Oncology, Faculty of Medicine, Erciyes University) ;
  • Karaca, Halit (Department of Medical Oncology, Faculty of Medicine, Erciyes University) ;
  • Dogan, Imran (Department of Medical Oncology, Faculty of Medicine, Erciyes University) ;
  • Berk, Veli (Department of Medical Oncology, Faculty of Medicine, Erciyes University) ;
  • Bozkurt, Oktay (Department of Medical Oncology, Faculty of Medicine, Erciyes University) ;
  • Ozaslan, Ersin (Department of Medical Oncology, Faculty of Medicine, Erciyes University) ;
  • Ucar, Mahmut (Department of Medical Oncology, Faculty of Medicine, Erciyes University) ;
  • Eroglu, Celalettin (Department of Medical Oncology, Faculty of Medicine, Erciyes University) ;
  • Ozkan, Metin (Department of Medical Oncology, Faculty of Medicine, Erciyes University)
  • 발행 : 2014.08.15
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Background: Prior studies showed a relationship between serum albumin and the albumin to globulin ratio with different types of cancer. We aimed to evaluate the predictive value of the albumin-globulin ratio (AGR) for survival of patients with lung adenocarcinoma. Materials and Methods: This retrospective study included 240 lung adenocarcinoma patients. Biochemical parameters before chemotherapy were collected and survival status was obtained from the hospital registry. The AGR was calculated using the equation AGR=albumin/(total protein-albumin) and ranked from lowest to highest, the total number of patients being divided into three equal tertiles according to the AGR values. Furthermore, AGR was divided into two groups (low and high tertiles) for ROC curve analysis. Cox model analysis was used to evaluate the prognostic value of AGR and AGR tertiles. Results: The mean survival time for each tertile was: for the $1^{st}$ 9.8 months (95%CI:7.765-11.848), $2^{nd}$ 15.4 months (95%CI:12.685-18.186), and $3^{rd}$ 19.9 months (95%CI:16.495-23.455) (p<0.001). Kaplan-Meier curves showed significantly higher survival rates with the third and high tertiles of AGR in comparison with the first and low tertiles, respectively. At multivariate analysis low levels of albumin and AGR, low tertile of AGR and high performance status remained an independent predictors of mortality. Conclusions: Low AGR was a significant predictor of long-term mortality in patients with lung adenocarcinoma. Serum albumin measurement and calculation of AGR are easily accessible and cheap to use for predicting mortality in patients with lung adenocarcinoma.

키워드

참고문헌

  1. Andersen S, Eilertsen M, Donnem T, et al (2011). Diverging prognostic impacts of hypoxic markers according to NSCLC histology. Lung Cancer, 72(3): 294-302. https://doi.org/10.1016/j.lungcan.2010.10.006
  2. Azab B, Kedia S, Shah N, et al (2013). The value of the pretreatment albumin/globulin ratio in predicting the longterm survival in colorectal cancer. Int J Colorectal Dis, 28,1629-36. https://doi.org/10.1007/s00384-013-1748-z
  3. Azab BN, Bhatt VR, Vonfrolio S, et al (2013). Value of the pretreatment albumin to globulin ratio in predicting long-term mortality in breast cancer patients. Am J Surg, 206,764-70. https://doi.org/10.1016/j.amjsurg.2013.03.007
  4. Canna K, McArdle PA, McMillan DC, et al (2005). The relationship between tumour T-lymphocyte infiltration, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancer. Br J Cancer, 92,651-4. https://doi.org/10.1038/sj.bjc.6602419
  5. Cueto Manzano AM (2001). Hypoalbuminemia in dialysis. Is it a marker for malnutrition or inflammation? Rev Invest Clin, 53,152-8.
  6. Dai J, Tang K, Xiao W, et al (2014). Prognostic significance of C-reactive protein in urological cancers: a systematic review and meta-analysis. Asian Pac J Cancer Prev, 15, 3369-75. https://doi.org/10.7314/APJCP.2014.15.8.3369
  7. Du XJ, Tang LL, Mao YP, et al (2014). The Pretreatment albumin to globulin ratio has predictive value for long-term mortality in nasopharyngeal carcinoma. PLoS ONE, 9, e94473. https://doi.org/10.1371/journal.pone.0094473
  8. de Geus-Oei LF, van Krieken JH, Aliredjo RP, et al (2007). Biological correlates of FDG uptake in non-small cell lung cancer. Lung Cancer, 55, 79-87. https://doi.org/10.1016/j.lungcan.2006.08.018
  9. Gabay C, Kushner I. (1999). Acute-phase proteins and other systemic responses to inflammation. N Engl J Med, 340, 448-54. https://doi.org/10.1056/NEJM199902113400607
  10. Greene FL, Page DL, Fleming ID (2002). AJCC cancer staging manual.6th ed. New York: Springer-Verlag.
  11. Guo YZ, Pan L, Du CJ, Ren DQ, Xie XM (2013). Association between C-reactive protein and risk of cancer: a metaanalysis of prospective cohort studies. Asian Pac J Cancer Prev, 14, 243-8. https://doi.org/10.7314/APJCP.2013.14.1.243
  12. Gupta D, Lis CG (2010). Pretreatment serum albumin as a predictor of cancersurvival: a systematic review of the epidemiological literature. Nutr J, 9, 69. https://doi.org/10.1186/1475-2891-9-69
  13. Jemal A, Siegel R, Xu J, Ward E (2010). Cancer statistics. CA Cancer J Clin, 60, 277-300. https://doi.org/10.3322/caac.20073
  14. Jin Y1, Zhao L, Peng F (2013). Prognostic impact of serum albumin levels on the recurrence of stage I non-small cell lung cancer. Clinics (Sao Paulo), 68, 686-93. https://doi.org/10.6061/clinics/2013(05)17
  15. Kaya V, Yildirim M, Demirpence O, Yildiz M, Yalcin AY (2013) Prognostic significance of basic laboratory methods in nonsmall-cell-lung cancer. Asian Pac J Cancer Prev, 14, 5473-6. https://doi.org/10.7314/APJCP.2013.14.9.5473
  16. Laky B, Janda M, Bauer J, et al (2007). Malnutrition among gynaecological cancer patients. Eur J Clin Nutr, 61, 642-6.
  17. Laursen I, Briand P, Lykkesfeldt AE (1990). Serum albumin as a modulator on growth of the human breast cancer cell line, MCF-7. Anticancer Res, 10, 343-51.
  18. Mantovani A, Allavena P, Sica A, Balkwill F (2008). Cancerrelated inflammation. Nature, 454, 436-44. https://doi.org/10.1038/nature07205
  19. McMillan DC (2009). Systemic inflammation, nutritional status and survival in patients with cancer. Curr Opin Clin Nutr Metab Care, 12, 223-6. https://doi.org/10.1097/MCO.0b013e32832a7902
  20. McPherson R. Specific proteins. In: McPherson RA, Pincus MR, editors (2006). Henry's clinical diagnosis and management by laboratory methods. 21st ed. New York: Saunders.
  21. Onate-Ocana LF, Aiello-Crocifoglio V, Gallardo-Rincon D, et al (2007). Serum albumin as a significant prognostic factor for patients with gastric carcinoma. Ann Surg Oncol, 14, 381-9. https://doi.org/10.1245/s10434-006-9093-x
  22. Shimada H, Nabeya Y, Okazumi S, et al (2003). Elevation of preoperative serum C-reactive protein level is related to poor prognosis in esophageal squamous cell carcinoma. J Surg Oncol, 83, 248-52. https://doi.org/10.1002/jso.10275
  23. Soliman NA, Keshk WA, Shoheib ZS, Ashour DS, Shamloula MM (2014). Inflammation, oxidative stress and L-fucose as indispensable participants in schistosomiasis-associated colonic dysplasia. Asian Pac J Cancer Prev, 15, 1125-31. https://doi.org/10.7314/APJCP.2014.15.3.1125
  24. Song XY, Zhou SJ, Xiao N, et al (2013). Research on the relationship between serum levels of inflammatory cytokines and non-small cell lung cancer. Asian Pac J Cancer Prev,14, 4765-8. https://doi.org/10.7314/APJCP.2013.14.8.4765
  25. Sonnenschein C, Soto AM, Michaelson CL (1996). Human serum albumin shares the properties of estrocolyone-I, the inhibitor of the proliferation of estrogen-target cells. J Steroid Biochem Mol Biol, 59, 147-54. https://doi.org/10.1016/S0960-0760(96)00112-4
  26. Unal D, Eroglu C, Kurtul N, Oguz A, Tasdemir A (2013). Are neutrophil/lymphocyte and platelet/lymphocyte rates in patients with non-small cell lung cancer associated with treatment response and prognosis? Asian Pac J Cancer Prev, 14, 5237-42. https://doi.org/10.7314/APJCP.2013.14.9.5237
  27. Yeun JY, Kaysen GA (1998). Factors influencing serum albumin in dialysis patients. Am J Kidney Dis, 32, 118-25.
  28. Yildirim M, Yildiz M, Duman E, Goktas S, Kaya V (2013). Prognostic importance of the nutritional status and systemic inflammatory response in non-small cell lung cancer. J BUON, 18, 728-32.
  29. Zheng YB, Zhao W, Liu B, et al (2013). The blood neutrophil-tolymphocyte ratio predicts survival in patients with advanced hepatocellular carcinoma receiving sorafenib. Asian Pac J Cancer Prev, 14, 5527-31. https://doi.org/10.7314/APJCP.2013.14.9.5527

피인용 문헌

  1. The Gamma Gap and All-Cause Mortality vol.10, pp.12, 2015, https://doi.org/10.1371/journal.pone.0143494
  2. Prognostic Significance of Preoperative Albumin-Globulin Ratio in Patients with Upper Tract Urothelial Carcinoma vol.10, pp.12, 2015, https://doi.org/10.1371/journal.pone.0144961
  3. The pretreatment albumin to globulin ratio predicts chemotherapeutic outcomes in patients with unresectable metastatic colorectal cancer vol.15, pp.1, 2015, https://doi.org/10.1186/s12885-015-1375-x
  4. Low pretreatment serum globulin may predict favorable prognosis for gastric cancer patients vol.37, pp.3, 2016, https://doi.org/10.1007/s13277-015-3778-3
  5. Pretreatment values of bilirubin and albumin are not prognostic predictors in patients with advanced pancreatic cancer pp.20457634, 2018, https://doi.org/10.1002/cam4.1848
  6. Preoperative albumin-to-globulin ratio predicts survival in patients with non-small-cell lung cancer after surgery pp.00219541, 2018, https://doi.org/10.1002/jcp.26766