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Age and Survival of Cervical Cancer Patients with Bone Metastasis

  • Nartthanarung, Adisak (Musculoskeletal Oncology Unit, Department of Orthopaedics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University) ;
  • Thanapprapasr, Kamolrat (National Metal and Materials Technology Center (MTEC), National Science and Technology Development Agency (NSTDA)) ;
  • Udomsubpayakul, Umaporn (Section of Clinical Epidemiology and Biostatistics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University) ;
  • Thanapprapasr, Duangmani (Department of Obstetrics and Gynecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University)
  • 발행 : 2014.10.23

초록

Background: To determine survival times of cervical cancer patients with bone metastasis related to the effect of age at the time of cervical cancer diagnosis, we performed the retrospectively analytical study. Methods: A total of 68 cervical cancer patients with bone metastasis were treated at a single hospital, during January 1998 to December 2010. Fifty-two medical records were identified and collected, the remaining sixteen medical records were not found. Main outcome measures were patient characteristics, clinical information, duration from cervical cancer diagnosis to bone metastasis diagnosis, survival time after bone metastasis and overall survival time. Results: Among fifty-two cervical cancer patients with bone metastasis, there were 13 patients who were less than 45 years old, and 39 patients were 45 years old or more at the time of cervical cancer diagnosis. The younger group had less median overall survival than the older group, with a statistically significant difference (21 months, 95% CI 19.93-22.06; 34 months, 95% CI 23.27-44.72, p = 0.021). However, they were comparable in the duration from cervical cancer diagnosis to bone metastasis diagnosis and the survival time after bone metastasis. Conclusion: Young patients with bone metastasis aged less than 45 years old at the time of cervical cancer diagnosis have a poorer prognosis than the elderly patients. Impact: To improve survival and quality of life, more intensive and novel multimodal treatments at the time of cervical cancer diagnosis should be considered in patients less than forty-five years, who can tolerate the side effects better.

Keywords

References

  1. Carozzi FM, Tornesello ML, Burroni E, et al (2010). Prevalence of human papillomavirus types in high-grade cervical intraepithelial neoplasia and cancer in Italy. Cancer Epidemiol Biomarkers Prev, 19, 2389-400. https://doi.org/10.1158/1055-9965.EPI-10-0131
  2. Chao A, Lin CT, Lai CH (2014). Updates in Systemic Treatment for Metastatic Cervical Cancer. Curr Treat Options Oncol, 15, 1-13. https://doi.org/10.1007/s11864-013-0273-1
  3. Coleman RL (2008). The Gynecologic Oncology Group's role in the treatment of recurrent cervix cancer: current clinical trials. Gynecol Oncol, 110, 77-80. https://doi.org/10.1016/j.ygyno.2008.04.017
  4. Connolly GN, Behm I, Osaki Y, et al (2011). The impact of menthol cigarettes on smoking initiation among nonsmoking young females in Japan. Int J Environ Res Public Health, 8, 1-14.
  5. de Sanjose S, Wheeler CM, Quint WG, et al (2013). Age-specific occurrence of HPV16- and HPV18-related cervical cancer. Cancer Epidemiol Biomarkers Prev, 22, 1313-8. https://doi.org/10.1158/1055-9965.EPI-13-0053
  6. Edelstein ZR, Madeleine MM, Hughes JP, et al (2009). Age of diagnosis of squamous cell cervical carcinoma and early sexual experience. Cancer Epidemiol Biomarkers Prev, 18, 1070-6. https://doi.org/10.1158/1055-9965.EPI-08-0707
  7. Ferlay J, Ervik M, Dikshit R, et al (2012). GLOBOCAN v1.0.
  8. Khuhaprema T, A P, Sriplung H, Wiangnon S, S Y S S (2012). Cervix uteri. In: Cancer in Thailand 2004-2006, vol. VI, 1st edn (eds Khuhaprema T, Attasara P, Sriplung H, Wiangnon S, Sumitsawan Y & Sangrajrang S), pp. 45-48. Bangkok Medical Publisher, Bangkok, Thailand.
  9. Khunamornpong S, Settakorn J, Sukpan K, et al (2013). Prognostic value of pathological characteristics of invasive margins in early-stage squamous cell carcinomas of the uterine cervix. Asian Pac J Cancer Prev, 14, 5165-9. https://doi.org/10.7314/APJCP.2013.14.9.5165
  10. Khunamornpong S, Lekawanvijit S, Settakorn J, et al (2013). Prognostic model in patients with early-stage squamous cell carcinomas of the uterine cervix: A combination of invasive margin pathological characteristics and lymphovascular space invasion. Asian Pac J Cancer Prev, 14, 6935-40. https://doi.org/10.7314/APJCP.2013.14.11.6935
  11. Nartthanarung A, Thanapprapasr D (2010). Comparison of outcomes for patients with cervical cancer who developed bone metastasis after the primary treatment with concurrent chemoradiation versus radiation therapy alone. Int J Gynecol Cancer, 20, 1386-90.
  12. Parkin DM, Bray F, Ferlay J, et al (2005). Global cancer statistics, 2002. CA Cancer J Clin, 55, 74-108. https://doi.org/10.3322/canjclin.55.2.74
  13. Roque DR, Cronin B, Robison K, et al (2013). The effects of age on treatment and outcomes in women with stages IB1-IIB cervical cancer. J Geriatr Oncol, 4, 374-81. https://doi.org/10.1016/j.jgo.2013.07.002
  14. Schiffman M, Castle PE, Jeronimo J, et al (2007). Human papillomavirus and cervical cancer. Lancet, 370, 890-907. https://doi.org/10.1016/S0140-6736(07)61416-0
  15. Seol HJ, Ki KD, Lee JM (2014). Epidemiologic characteristics of cervical cancer in Korean women. J Gynecol Oncol, 25, 70-4. https://doi.org/10.3802/jgo.2014.25.1.70
  16. Thanapprapasr D, Hu W, Sood AK, et al (2012). Moving beyond VEGF for anti-angiogenesis strategies in gynecologic cancer. Curr Pharm Des, 18, 2713-9. https://doi.org/10.2174/138161212800626201
  17. Thanapprapasr D, Nartthanarung A, Likittanasombut P, et al (2010). Bone metastasis in cervical cancer patients over a 10-year period. Int J Gynecol Cancer, 20, 373-8. https://doi.org/10.1111/IGC.0b013e3181d4a0a1
  18. Wang SS, Sherman ME, Hildesheim A, et al (2004). Cervical adenocarcinoma and squamous cell carcinoma incidence trends among white women and black women in the United States for 1976-2000. Cancer, 100, 1035-44. https://doi.org/10.1002/cncr.20064

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