Asian Pacific Journal of Cancer Prevention

  • 제15권20호
  • /
  • Pages.8887-8891
  • /
  • 2014
  • /
  • 1513-7368(pISSN)
  • /
  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
권호 표지
DOI QR코드

DOI QR Code

Survival Analysis of Oral Squamous Cell Carcinoma in a Subgroup of Young Patients

  • Fan, Yi (Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology) ;
  • Zheng, Lei (Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology) ;
  • Mao, Ming-Hui (Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology) ;
  • Huang, Ming-Wei (Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology) ;
  • Liu, Shu-Ming (Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology) ;
  • Zhang, Jie (Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology) ;
  • Li, Sheng-Lin (Central Laboratory, Peking University School and Hospital of Stomatology) ;
  • Zheng, Lei (Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology) ;
  • Zhang, Jian-Guo (Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology)
  • 발행 : 2014.11.06
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Oral squamous cell carcinoma (OSCC) is predominantly a disease of middle-aged men with long-term exposure to tobacco and alcohol. An increasing trend has been reported at a younger age worldwide. Clinical records of 100 patients under the age of 45 years treated specifically for oral cavity SCC in our hospital during a 10-year period were retrospectively analyzed to calculate the survival rates. An obvious male predominance coincided with smoking trend among Chinese young individuals and female patients were more likely to have no traditional risk factors such as smoking or drinking. The 5-year overall survival rate and disease-free survival rate were 61.0% and 75.5%, respectively, consistent with other published series over the decade showing a relatively better survival among the young. No significant differences clearly correlated with outcome when comparing non-smokers non-drinkers to ever-smokers and ever drinkers (P>0.05). Overall survival rate and disease free survival rate was found to be significantly higher in patients with early-stage disease than with advanced stage disease (P=0.001, P=0.009 respectively). The strong influence of clinical stage on prognosis emphasizes the importance of early diagnosis and treatment of oral malignancies for this unique clinical subgroup.

키워드

참고문헌

  1. Annertz K, Anderson H, Biorklund A, et al (2002). Incidence and survival of squamous cell carcinoma of the tongue in Scandinavia, with special reference to young adults. Int J Cancer, 101, 95-9. https://doi.org/10.1002/ijc.10577
  2. Chang TS, Chang CM, Ho HC, et al (2013). Impact of young age on the prognosis for oral cancer: a population-based study in taiwan. PLoS One, 8, 75855. https://doi.org/10.1371/journal.pone.0075855
  3. Dahlstrom KR, Little JA, Zafereo ME, et al (2008). Squamous cell carcinoma of the head and neck in never smoker-never drinkers: a descriptive epidemiologic study. Head Neck, 30, 75-84. https://doi.org/10.1002/hed.20664
  4. Durr ML, van Zante A, Li D, et al (2013). Oral tongue squamous cell carcinoma in never-smokers: analysis of clinicopathologic characteristics and survival. Otolaryngol Head Neck Surg, 149, 89-96. https://doi.org/10.1177/0194599813482876
  5. Farshadpour F, Hordijk G, Koole R, et al (2007). Non-smoking and non-drinking patients with head and neck squamous cell carcinoma: a distinct population. Oral Diseases, 13, 239-43. https://doi.org/10.1111/j.1601-0825.2006.01274.x
  6. Ganly I, Patel S, Shah J (2012). Early stage squamous cell cancer of the oral tongue-clinicopathologic features affecting outcome. Cancer, 118, 101-11. https://doi.org/10.1002/cncr.26229
  7. Goot-Heah K, Kwai-Lin T, Froemming GRA, et al (2012). Human papilloma virus 18 detection in oral squamous cell carcinoma and potentially malignant lesions using saliva samples. Asian Pac J Cancer Prev, 13, 6109-13. https://doi.org/10.7314/APJCP.2012.13.12.6109
  8. Hafkamp HC, Manni JJ, Haesevoets A, et al (2008). Marked differences in survival rate between smokers and nonsmokers with HPV 16-associated tonsillar carcinomas. Int J Cancer, 122, 2656-64. https://doi.org/10.1002/ijc.23458
  9. Harris SL, Kimple RJ, Hayes DN, et al (2010). Never-smokers, never-drinkers: unique clinical subgroup of young patients with head and neck squamous cell cancers. Head Neck, 32, 499-503.
  10. Iamaroon A, Pattanaporn K, Pongsiriwet S, et al (2004). Analysis of 587 cases of oral squamous cell carcinoma in northern Thailand with a focus on young people. Int J Oral Maxillofacial Surgery, 33, 84-8. https://doi.org/10.1054/ijom.2003.0503
  11. Isayeva T, Li Y, Maswahu D, et al (2012). Human papillomavirus in non-oropharyngeal head and neck cancers: a systematic literature review. Head Neck Pathol, 6, 104-20. https://doi.org/10.1007/s12105-012-0368-1
  12. Kaminagakura E, Villa LL, Andreoli MA, et al (2012). High-risk human papillomavirus in oral squamous cell carcinoma of young patients. Int J Cancer, 130, 1726-32. https://doi.org/10.1002/ijc.26185
  13. Khovidhunkit SO, Buajeeb W, Sanguansin S, et al (2008). Detection of human papillomavirus in oral squamous cell carcinoma, leukoplakia and lichen planus in Thai patients. Asian Pac J Cancer Prev, 9, 771-5.
  14. Kies MS, Boatright DH, Li G, et al (2012). Phase II trial of induction chemotherapy followed by surgery for squamous cell carcinoma of the oral tongue in young adults. Head & Neck, 34, 1255-62. https://doi.org/10.1002/hed.21906
  15. Klozar J, Koslabova E, Kratochvil V, et al (2013). Nodal status is not a prognostic factor in patients with HPV-positive oral/oropharyngeal tumors. J Surg Oncol, 107, 625-33. https://doi.org/10.1002/jso.23292
  16. Koo K, Barrowman R, McCullough M, et al (2013). Nonsmoking non-drinking elderly females: a clinically distinct subgroup of oral squamous cell carcinoma patients. Int J Oral Maxillofac Surg, 42, 929-33. https://doi.org/10.1016/j.ijom.2013.04.010
  17. Kreimer AR, Pierce Campbell CM, Lin HY, et al (2013). Incidence and clearance of oral human papillomavirus infection in men: the HIM cohort study. Lancet, 382, 877-87. https://doi.org/10.1016/S0140-6736(13)60809-0
  18. Krishna A, Singh R, Singh S, et al (2014). Demographic risk factors, affected anatomical sites and clinicopathological profile for oral squamous cell carcinoma in a north Indian population. Asian Pac J Cancer Prev, 15, 6755-60. https://doi.org/10.7314/APJCP.2014.15.16.6755
  19. Li Q, Hsia J, Yang G (2011). Prevalence of smoking in China in 2010. New England Journal of Medicine, 364, 2469-70. https://doi.org/10.1056/NEJMc1102459
  20. Li R, Koch WM, Fakhry C, et al (2013). Distinct epidemiologic characteristics of oral tongue cancer patients. Otolaryngol Head Neck Surg, 148, 792-6. https://doi.org/10.1177/0194599813477992
  21. Llewellyn CD, Johnson NW, Warnakulasuriya KA (2001). Risk factors for squamous cell carcinoma of the oral cavity in young people-a comprehensive literature review. Oral Oncology, 37, 401-18. https://doi.org/10.1016/S1368-8375(00)00135-4
  22. Llewellyn CD, Linklater K, Bell J, et al (2004). An analysis of risk factors for oral cancer in young people: a case-control study. Oral Oncology, 40, 304-13. https://doi.org/10.1016/j.oraloncology.2003.08.015
  23. Manuel S, Raghavan SK, Pandey M, et al (2003). Survival in patients under 45 years with squamous cell carcinoma of the oral tongue. Int J Oral Maxillofac Surg, 32, 167-73. https://doi.org/10.1054/ijom.2002.0271
  24. Myers JN, Elkins T, Roberts D, et al (2000). Squamous cell carcinoma of the tongue in young adults: Increasing incidence and factors that predict treatment outcomes. Otolaryngology-Head and Neck Surgery, 122, 44-51. https://doi.org/10.1016/S0194-5998(00)70142-2
  25. Patel SC, Carpenter WR, Tyree S, et al (2011). Increasing incidence of oral tongue squamous cell carcinoma in young white women, age 18 to 44 years. J Clin Oncol, 29, 1488-94. https://doi.org/10.1200/JCO.2010.31.7883
  26. Sasaki T, Moles D, Imai Y, et al (2005). Clinico-pathological features of squamous cell carcinoma of the oral cavity in patients<40 years of age. J Oral Pathol Med, 34, 129-33. https://doi.org/10.1111/j.1600-0714.2004.00291.x
  27. Sherin N, Simi T, Shameena P, et al (2008). Changing trends in oral cancer. Indian J Cancer, 45, 93. https://doi.org/10.4103/0019-509X.44063
  28. Siebers TJ, Merkx MA, Slootweg PJ, et al (2008). No high-risk HPV detected in SCC of the oral tongue in the absolute absence of tobacco and alcohol-a case study of seven patients. Oral Maxillofac Surg, 12, 185-8. https://doi.org/10.1007/s10006-008-0131-7
  29. van Monsjou HS, Lopez-Yurda MI, Hauptmann M, et al (2013). Oral and oropharyngeal squamous cell carcinoma in young patients: The Netherlands Cancer Institute experience. Head & Neck, 35, 94-102. https://doi.org/10.1002/hed.22935
  30. Warnakulasuriya S (2009). Global epidemiology of oral and oropharyngeal cancer. Oral Oncol, 45, 309-16. https://doi.org/10.1016/j.oraloncology.2008.06.002

피인용 문헌

  1. Head and Neck Squamous Cell Carcinoma - Comparative Evaluation of Pathological Parameters in Young and Old Patients vol.16, pp.9, 2015, https://doi.org/10.7314/APJCP.2015.16.9.4061
  2. Ten-year analysis of oral cancer focusing on young people in northern Thailand vol.57, pp.4, 2015, https://doi.org/10.2334/josnusd.57.327