The Korean Journal of Physiology and Pharmacology

  • 제19권1호
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  • Pages.15-20
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  • 2015
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  • 1226-4512(pISSN)
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  • 2093-3827(eISSN)
대한약리학회 (The Korean Society of Pharmacology)
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Extremely Low Frequency Magnetic Field Modulates the Level of Neurotransmitters

  • Chung, Yoon Hee (Department of Anatomy, College of Medicine, Chung-Ang University) ;
  • Lee, Young Joo (Department of Pharmacology, College of Medicine, Chung-Ang University) ;
  • Lee, Ho Sung (Department of Pharmacology, College of Medicine, Chung-Ang University) ;
  • Chung, Su Jin (Department of Pharmacology, College of Medicine, Chung-Ang University) ;
  • Lim, Cheol Hee (Department of Pharmacology, College of Medicine, Chung-Ang University) ;
  • Oh, Keon Woong (Christmas Clinic) ;
  • Sohn, Uy Dong (Department of Pharmacology, College of Pharmacy, Chung-Ang University) ;
  • Park, Eon Sub (Department of Pathology, College of Medicine, Chung-Ang University) ;
  • Jeong, Ji Hoon (Department of Pharmacology, College of Medicine, Chung-Ang University)
  • 투고 : 2014.08.02
  • 심사 : 2014.11.22
  • 발행 : 2015.01.30
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초록

This study was aimed to observe that extremely low frequency magnetic field (ELF-MF) may be relevant to changes of major neurotransmitters in rat brain. After the exposure to ELF-MF (60 Hz, 2.0 mT) for 2 or 5 days, we measured the levels of biogenic amines and their metabolites, amino acid neurotransmitters and nitric oxide (NO) in the cortex, striatum, thalamus, cerebellum and hippocampus. The exposure of ELF-MF for 2 or 5 days produced significant differences in norepinephrine and vanillyl mandelic acid in the striatum, thalamus, cerebellum and hippocampus. Significant increases in the levels of serotonin and 5-hydroxyindoleacetic acid were also observed in the striatum, thalamus or hippocampus. ELF-MF significantly increased the concentration of dopamine in the thalamus. ELF-MF tended to increase the levels of amino acid neurotransmitters such as glutamine, glycine and ${\gamma}$-aminobutyric acid in the striatum and thalamus, whereas it decreased the levels in the cortex, cerebellum and hippocampus. ELF-MF significantly increased NO concentration in the striatum, thalamus and hippocampus. The present study has demonstrated that exposure to ELF-MFs may evoke the changes in the levels of biogenic amines, amino acid and NO in the brain although the extent and property vary with the brain areas. However, the mechanisms remain further to be characterized.

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