Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics (대한후두음성언어의학회지)

The Korean Society of Laryngology, Phoniatrics and Logopedics. (대한후두음성언어의학회)
권호 표지

A Case of Recurrent Spindle Cell Epithelial Tumor of Thymus-Like Differentiation (SETTLE) in the Glottis

성문에서 발생한 재발성 흉선상 방추상 상피세포 종양(Spindle Epithelial Tumor with Thymus-Like Differentiation, SETTLE) 1예

  • Park, Woori (Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Choi, Nayeon (Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Chung, Man Ki (Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • 박우리 (성균관대학교 의과대학 삼성서울병원 이비인후과학교실) ;
  • 최나연 (성균관대학교 의과대학 삼성서울병원 이비인후과학교실) ;
  • 정만기 (성균관대학교 의과대학 삼성서울병원 이비인후과학교실)
  • Received : 2015.07.30
  • Accepted : 2015.08.06
  • Published : 2015.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Spindle epithelial tumor with thymus-like differentiation (SETTLE) is an extremely rare type of thyroid tumor, with spares reports on its clinical course. SETTLE is derived from branchial pouch or thymic remnants, and classified as a low grade, malignant neoplasm due to its indolent growth and tendency to develop delayed metastasis. Therefore, stringent initial workups and long-term follow-up are required to prevent misdiagnosis. We present a case of recurrent spindle epithelial tumor with thymus-like differentiation (SETTLE) in the glottis of 57 year-old male patient, who had a history of surgical excision for the SETTLE from the thyroid gland 5 years ago. Transoral CO2 laser surgery was performed to remove the glottic tumor and there was no evidence of local recurrence at 11 months postoperatively.

Keywords

References

  1. Chan J, Rosal J. Tumors of the neck showing thymic or related branchial pouch differentiation: a unifying concept. Human Pathology 1991;22(4):349-67. https://doi.org/10.1016/0046-8177(91)90083-2
  2. Recondo G, Busaidy N, Erasmus J, Williams MD, Johnson FM. Spindle epithelial tumor with thymus-like differentiation: A case report and comprehensive review of the literature and treatment options. Head & Neck 2015;37(5):746-54. https://doi.org/10.1002/hed.23634
  3. Abrosimov AY, LiVolsi VA. Spindle epithelial tumor with thymus-like differentiation (SETTLE) of the thyroid with neck lymph node metastasis: a case report. Endocrine Pathology 2005;16(2):139-43. https://doi.org/10.1385/EP:16:2:139
  4. Cheuk W, Jacobson AA, Chan JK. Spindle epithelial tumor with thymus-like differentiation (SETTLE): a distinctive malignant thyroid neoplasm with significant metastatic potential. Modern Pathology 2000;13(10):1150-5. https://doi.org/10.1038/modpathol.3880212
  5. Misra RK, Mitra S, Yadav R, Bundela A. Spindle Epithelial Tumor with Thymus-Like Differentiation: A Case Report and Review of Literature. Acta Cytologica 2013;57(3):303-8. https://doi.org/10.1159/000346704
  6. Raffel A, Cupisti K, Rees M, Janig U, Bernbeck B, Jazbec J, et al. Spindle Epithelial Tumour with Thymus-like Differentiation (SETTLE) of the Thyroid Gland with Widespread Metastases in a 13-year-old Girl. Clinical Oncology 2003;15(8):490-5. https://doi.org/10.1016/S0936-6555(03)00153-5
  7. Grushka JR, Ryckman J, Mueller C, de Buys Roessingh A, Walton JM, Vil DS, et al. Spindle epithelial tumor with thymus-like elements of the thyroid: a multi-institutional case series and review of the literature. Journal of Pediatric Surgery 2009;44(5):944-8. https://doi.org/10.1016/j.jpedsurg.2009.01.030
  8. Kloboves-Prevodnik V, Jazbec J, Us-Krasovec M, Lamovec J. Thyroid spindle epithelial tumor with thymus-like differentiation (SETTLE): Is cytopathological diagnosis possible? Diagnostic Cytopathology 2002;26(5):314-9. https://doi.org/10.1002/dc.10107
  9. Folpe AL, Lloyd RV, Bacchi CE, Rosai J. Spindle epithelial tumor with thymus-like differentiation: a morphologic, immunohistochemical, and molecular genetic study of 11 cases. The American Journal of Surgical Pathology 2009;33(8):1179-86. https://doi.org/10.1097/PAS.0b013e31819e61c8
  10. Lee F-Y, Wen M-C, Jan Y-J, Wang J. The predominant monophasic variant of spindle epithelial tumour with thymus-like differentiation (SETTLE) of neck soft tissue with late pulmonary metastasis. Pathology 2010;42(2):188-90. https://doi.org/10.3109/00313020903494037
  11. Su L, Beals T, Bernacki EG, Giordano TJ. Spindle epithelial tumor with thymus-like differentiation: a case report with cytologic, histologic, immunohistologic, and ultrastructural findings. Modern pathology: an Official Journal of the United States and Canadian Academy of Pathology, Inc 1997;10(5):510-4.
  12. Kingsley D, Elton A, Bennett M. Malignant teratoma of the thyroid. Case report and a review of the literature. British Journal of Cancer 1968;22(1):7. https://doi.org/10.1038/bjc.1968.2