DOI QR코드

DOI QR Code

Efficacy of Bifidobacterium Tetragenous Viable Bacteria Tablets for Cancer Patients with Functional Constipation

  • Liu, Jin (Department of Chemotherapy, the Affiliated Jiangsu Cancer Hospital of Nanjing Medical University & Jiangsu Institute of Cancer Research) ;
  • Huang, Xin-En (Department of Chemotherapy, the Affiliated Jiangsu Cancer Hospital of Nanjing Medical University & Jiangsu Institute of Cancer Research)
  • 발행 : 2015.01.06

초록

Objective: To investigate the efficacy and side effects of Bifidobacterium tetragenous viable bacteria tablets in treating cancer patients with functional constipation during chemotherapy. Methods: A consecutive cohort of 100 cancer patients with functional constipation were divided into two equal groups: patients in the experimental group were given Bifidobacterium tetragenous viable bacteria tablets combined with chemotherapy, while patients in the control group received chemotherapy alone. After 4 weeks, the efficacy and side effects in treating functional constipation were evaluated. Results: Constipation in 48 patients in experimental group was controlled (9 returned to normal), with a total response rate of 96%, and 1 patient reported diarrhea (2%). In contrast only 16 patients in the control group demonstrated improvement and 34 were still constipated after chemotherapy, with a response rate of 32%. The difference in response rate was statistically significant (P<0.05). Conclusion: This study suggested that Bifidobacterium tetragenous viable bacteria tablets are effective and safe in treating cancer patients with functional constipation during chemotherapy.

키워드

References

  1. Abrams GD, Bishop JE, et al (1967). Effect of the normal microbial flora on gastrointestinal motility. Proc Soc Exp Biol Med, 126, 301-4. https://doi.org/10.3181/00379727-126-32430
  2. Agrawal A, Houghton LA, Morris J, et al (2009). Clinical trial: the effects of a fermented milk product containing Bifidobacterium lactis DN-173 010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipation. Aliment Pharmacol Ther, 29, 104-14. https://doi.org/10.1111/j.1365-2036.2008.03853.x
  3. Andrews PL, Davis CJ, Bingham S, et al (1990). The abdominal visceral innervation and the emetic reflex: pathways, pharmacology, and plasticity. Can J Physiol Pharmacol, 68, 325-45 https://doi.org/10.1139/y90-047
  4. Andrews PLR, Rapeport WG, Sanger GJ (1988). Neuropharmacology of emesis induced by anti-cancer therapy. Trends Pharmacol Sci, 9, 334-41 https://doi.org/10.1016/0165-6147(88)90106-X
  5. Badary OA, Awad AS, Sherief MA, et al (2006). In vitro and in vivo effects of ferulic acid on gastrointestinal motility: inhibition of cisplatin-induced delay in gastric emptying in rats. World J Gastroenterol, 12, 5363-7 https://doi.org/10.3748/wjg.v12.i33.5363
  6. Blokhina LV, Kochetkov AM (2001). Functional constipation syndrome: experience in the use of sour milk products and biologically active food supplements in the complex treatment of patients. Vopr Pitan, 70, 29-32.
  7. Botrel TE, Clark OA, Clark L, et al (2011). Efficacy of palonosetron (PAL). compared to other serotonin inhibitors (5-HT3R). in preventing chemotherapy-induced nausea and vomiting (CINV). in patients receiving moderately or highly emetogenic (MoHE). treatment: systematic review and metaanalysis. Support Care Cancer, 19, 823-32. https://doi.org/10.1007/s00520-010-0908-8
  8. De Paula JA, Carmuega E, Weill R, et al (2008). Effect of the ingestion of a symbiotic yogurt on the bowel habits of women with functional constipation. Acta Gastroenterol Latinoam, 38, 16-25.
  9. Dimidi E, Christodoulides S, Fragkos KC, et al (2014). The effect of probiotics on functional constipation in adults: a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr, 100, 1075-84. https://doi.org/10.3945/ajcn.114.089151
  10. El-Salhy M, Svensen R, Hatlebakk JG, Gilja OH, Hausken T (2014). Chronic constipation and treatment options (Review). Mol Med Rep, 9, 3-8
  11. Faria C, Li X, Nagln N, et al (2014). Outcomes associated with 5-HT3-RA therapy selection in patients with chemotherapyinduced nausea and vomiting: a retrospective claims analysis. Am Health Drug Benefits, 7, 50-8.
  12. Gibas-Dorna M, Piątek J, et al (2014).. Functional constipation in children evaluation and management. Prz Gastroenterol, 9, 194-9.
  13. Husebye E, Hellstrom PM, et al (2001). Influence of microbial species on small intestinal myoelectric activity and transit in germ-free rats. Am J Physiol Gastrointest Liver Physiol, 280, G368-80.
  14. Favretto DC, Pontin B, et al (2013). Effect of the consumption of a cheese enriched with probiotic organisms (Bifidobacterium lactis bi-07). in improving symptoms of constipation. Arq Gastroenterol, 50, 196-201 https://doi.org/10.1590/S0004-28032013000200035
  15. Liu J, Huang XE, Tian GY, et al (2013). Phase II study on safety and efficacy of Yadanzi(R) (Javanica oil emulsion injection). combined with chemotherapy for patients with gastric cancer. Asian Pac J Cancer Prev, 14, 2009-12. https://doi.org/10.7314/APJCP.2013.14.3.2009
  16. Liu YC, Zhou SB, Gao F, et al (2013). Chemotherapy and late course three dimensional conformal radiotherapy for treatment of patients with stage III non- small cell lung cancer. Asian Pac J Cancer Prev, 14, 2663-5 https://doi.org/10.7314/APJCP.2013.14.4.2663
  17. Lu YY, Huang XE, Xu L, et al (2013). Potential predictors of sensitivity to pemetrexed as first-line chemotherapy for patients with advanced non-squamous NSCLCs. Asian Pac J Cancer Prev, 14, 2005-8. https://doi.org/10.7314/APJCP.2013.14.3.2005
  18. Pare P, Fedorak RN (2014). Systematic review of stimulant and nonstimulant laxatives for the treatment of functional constipation. Can J Gastroenterol Hepatol, 28, 549-57. https://doi.org/10.1155/2014/631740
  19. Sabikhi L, Kumar MH, Mathur BN (2014). Bifidobacterium bifidum in probiotic Edam cheese: influence on cheese ripening. J Food Sci Technol, 51, 3902-9. https://doi.org/10.1007/s13197-013-0945-7
  20. Smecuol E, Hwang HJ, Sugai E, et al (2013). Exploratory, randomized, double-blind, placebo-controlled study on the effects of Bifidobacterium infantis natren life start strain super strain in active celiac disease. J Clin Gastroenterol, 47, 139-47. https://doi.org/10.1097/MCG.0b013e31827759ac
  21. Tabbers MM, de Milliano I, Roseboom MG, Benninga MA (2011). Is Bifidobacterium breve effective in the treatment of childhood constipation? Results from a pilot study. Nutr J, 23, 10-9
  22. Wei GL, Huang XE, Huo JG, Wang XN, Tang JH (2013). Phase II study on pemetrexed-based chemotherapy in treating patients with metastatic gastric cancer not responding to prior palliative chemotherapy. Asian Pac J Cancer Prev, 14, 2703-6. https://doi.org/10.7314/APJCP.2013.14.5.2703
  23. Wu XY, Huang XE, You SX, et al (2013). Phase II study of pemetrexed as second or third line combined chemotherapy in patients with colorectal cancer. Asian Pac J Cancer Prev, 14, 2019-22. https://doi.org/10.7314/APJCP.2013.14.3.2019
  24. Xu X, Wang L, Xu HQ, et al (2013). Clinical comparison between paclitaxel liposome (Lipusu(R)). and paclitaxel for treatment of patients with metastatic gastric cancer. Asian Pac J Cancer Prev, 14, 2591-4. https://doi.org/10.7314/APJCP.2013.14.4.2591
  25. Zhan YP, Huang XE, Cao J (2012). Clinical safety and efficacy of Kanglaite$^{(R)}$ (Coix Seed Oil). injection combined with chemotherapy in treating patients with gastric cancer. Asian Pac J Cancer Prev, 13, 5319-21. https://doi.org/10.7314/APJCP.2012.13.10.5319
  26. Zoppi G, Cinquetti M, Luciano A, et al (1998). The intestinal ecosystem in chronic functional constipation. Acta Paediatr, 87, 836-41. https://doi.org/10.1111/j.1651-2227.1998.tb01547.x

Cited by

  1. Bifidobacterium adolescentis Exerts Strain-Specific Effects on Constipation Induced by Loperamide in BALB/c Mice vol.18, pp.2, 2017, https://doi.org/10.3390/ijms18020318