Asian Pacific Journal of Cancer Prevention

  • 제16권2호
  • /
  • Pages.485-488
  • /
  • 2015
  • /
  • 1513-7368(pISSN)
  • /
  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
권호 표지
DOI QR코드

DOI QR Code

Manganese Superoxide Dismutase (MnSOD Val-9Ala) Gene Polymorphism and Susceptibility to Gastric Cancer

  • Moradi, Mohammad-Taher (Medical Biology Research Center, Kermanshah University of Medical Sciences) ;
  • Yari, Kheirollah (Medical Biology Research Center, Kermanshah University of Medical Sciences) ;
  • Rahimi, Zohreh (Medical Biology Research Center, Kermanshah University of Medical Sciences) ;
  • Kazemi, Elham (Medical Biology Research Center, Kermanshah University of Medical Sciences) ;
  • Shahbazi, Mehrdad (Islamic Azad University of Ahar)
  • 발행 : 2015.02.25
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Background: Oxidative stress caused by the generation of reactive oxygen species plays an important role in human carcinogenesis. Manganese superoxide dismutase (MnSOD) Val-9Ala in the mitochondrial target sequence is the best known polymorphism of this enzyme. The purpose of the current research was to assess the association of MnSOD Val-9Ala genotypes with the risk of gastric cancer. Materials and Methods: This case-control study covered 54 gastric cancer patients compared to 100 cancer free subjects as controls. Extraction of DNA was performed on bioptic samples and genotypes were identified with a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: The frequencies of MnSOD Ala/Ala, Ala/Val and Val/Val genotypes in healthy individuals were 24.3, 66.7 and 9%, respectively. However, in gastric cancer patients, Ala/Ala, Ala/Val and Val/Val were observed in 24.0, 48.0 and 28.0% (p=0.01). In patients the frequency of MnSOD Val allele was higher (52%) compared to that in controls (42%). Conclusions: The results of this study show a positive association between MnSOD Val-9Ala gene polymorphism and risk of gastric cancer disease in Iranian population.

키워드

참고문헌

  1. Ambrosone CB, Ahn J, Singh KK, et al (2005). Polymorphisms in genes related to oxidative stress (MPO, MnSOD, CAT) and survival after treatment for breast cancer. Cancer Res, 65, 1105-11.
  2. Atoum M, Abdel-Fattah M, Nimer N, Abdel-Rahman S, Abdeldayem SA (2012). Association of alanine-valine manganese superoxide dismutase gene polymorphism and microheterogeneity manganese superoxide dismutase activity in breast cancer and benign breast tissue. J Breast Cancer, 15, 157-61. https://doi.org/10.4048/jbc.2012.15.2.157
  3. Attatippaholkun W, Wikainapakul K (2013). Predominant genotypes and alleles of two functional polymorphisms in the manganese superoxide dismutase gene are not associated with thai cervical or breast cancer. Asian Pac J Cancer Prev, 14, 3955-61. https://doi.org/10.7314/APJCP.2013.14.6.3955
  4. Augusto AC, Miguel F, Mendonca S, et al (2007a). Oxidative stress expression status associated to Helicobacter pylori virulence in gastric diseases. Clin Biochem, 40, 615-22. https://doi.org/10.1016/j.clinbiochem.2007.03.014
  5. Augusto AC, Miguel F, Mendonca S, et al (2007b). Oxidative stress expression status associated to Helicobacter pylorivirulence in gastric diseases. Clin Biochem, 40, 615-22. https://doi.org/10.1016/j.clinbiochem.2007.03.014
  6. Cerutti PA (1985). Prooxidant states and tumor promotion. Science, 227, 375-81. https://doi.org/10.1126/science.2981433
  7. Egan KM, Thompson PA, Titus-Ernstoff L, et al (2003). MnSOD polymorphism and breast cancer in a population-based case-control study. Cancer letters, 199, 27-33. https://doi.org/10.1016/S0304-3835(03)00349-5
  8. Fallah M (2007). Cancer Incidence in Five Provinces of Iran: Ardebil, Gilan, Mazandaran, Golestan and Kerman, 1996-2000.
  9. Humans IWGotEoCRt 1994. Schistosomes, liver flukes and Helicobacter pylori, World Health Organization.
  10. Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  11. Lin WL, Sun JL, Chang SC, et al (2014). Factors predicting survival of patients with gastric cancer. Asian Pac J Cancer Prev, 15, 5835-8. https://doi.org/10.7314/APJCP.2014.15.14.5835
  12. Macmillan-Crow LA, Cruthirds DL (2001). Manganese superoxide dismutase in disease. Free Radical Res, 34, 325-36. https://doi.org/10.1080/10715760100300281
  13. Margaret AL, Syahruddin E, Wanandi SI (2011). Low activity of manganese superoxide dismutase (MnSOD) in blood of lung cancer patients with smoking history: relationship to oxidative stress. Asian Pac J Cancer Prev, 12, 3049-53.
  14. Moges F, Kassu A, Mengistu G, et al (2006). Seroprevalence of Helicobacter pylori in dyspeptic patients and its relationship with HIV infection, ABO blood groups and life style in a university hospital, Northwest Ethiopia. World J Gastroenterol, 12, 1957. https://doi.org/10.3748/wjg.v12.i12.1957
  15. Moradi MT (2014). A Novel, efficient, fast and inexpensive DNAextraction protocol from whole blood applicable for studying drug-DNA interaction. J Rep Pharm Sci, 3, 80-4.
  16. Moradi MT, Hashtchin AR, Yari K (2013). Helicobacter pylori cagA-positive strains: gastric cancer susceptibility. Biharean Biologist, 7, 86-9.
  17. Shimoda-Matsubayashi S, Matsumine H, Kobayashi T, et al (1996). Structural dimorphism in the mitochondrial targeting sequence in the human manganese superoxide dismutase gene: a predictive evidence for conformational change to influence mitochondrial transport and a study of allelic association in Parkinson's disease. Biochem Biophy Res Commun, 226, 561-5. https://doi.org/10.1006/bbrc.1996.1394
  18. Sun G-G, Hu W-N, Wang Y-D, et al (2012). Bidirectional regulation of manganese superoxide dismutase (MnSOD) on the radiosensitivity of esophageal cancer cells. Asian Pac J Cancer Prev, 13, 3015-23. https://doi.org/10.7314/APJCP.2012.13.7.3015
  19. Sun G-G, Wang Y-D, Lu Y-F, et al (2013). Different association of manganese superoxide dismutase gene polymorphisms with risk of prostate, esophageal, and lung cancers: evidence from a meta-analysis of 20,025 subjects. Asian Pac J Cancer Prev, 14, 1937-43. https://doi.org/10.7314/APJCP.2013.14.3.1937
  20. Sutton A, Khoury H, Prip-Buus C, et al (2003). The Ala16Val genetic dimorphism modulates the import of human manganese superoxide dismutase into rat liver mitochondria. Pharmacogenetics, 13, 145-57. https://doi.org/10.1097/00008571-200303000-00004
  21. Wang S, Wang F, Shi X, et al (2009). Association between manganese superoxide dismutase (MnSOD Val-9Ala polymorphism and cancer risk-A meta-analysis. Eur J Cancer, 45, 2874-81. https://doi.org/10.1016/j.ejca.2009.04.024
  22. Yari K, Fatemi SSa, Tavallaei M (2010). Optimization of the BoNT/A-Hc expression in recombinant Escherichia coli using the Taguchi statistical method. Biotechnol appl biochem, 56, 35-42. https://doi.org/10.1042/BA20090315
  23. Zare A, Mahmoodi M, Mohammad K, et al (2013). Survival analysis of patients with gastric cancer undergoing surgery at the Iran cancer institute: a method based on multi-state models. Asian Pac J Cancer Prev, 14, 6369-73. https://doi.org/10.7314/APJCP.2013.14.11.6369

피인용 문헌

  1. Serum 8 Hydroxydeoxyguanosine and Cytotoxin Associated Gene A as Markers for Helicobacter pylori Infection vol.16, pp.13, 2015, https://doi.org/10.7314/APJCP.2015.16.13.5199
  2. The GPX1 Pro198Leu polymorphism in gastric cancer patients with and without Helicobacter pylori infection vol.39, pp.11, 2017, https://doi.org/10.1007/s13258-017-0594-8
  3. Association between Polymorphisms of Antioxidant Gene (MnSOD, CAT, and GPx1) and Risk of Coronary Artery Disease vol.2018, pp.2314-6141, 2018, https://doi.org/10.1155/2018/5086869
  4. Val16Ala Polymorphism and Cancer Risk: Evidence from 33,098 Cases and 37,831 Controls vol.2018, pp.1875-8630, 2018, https://doi.org/10.1155/2018/3061974
  5. vol.10, pp.5, 2018, https://doi.org/10.1039/C7MT00348J