Asian Pacific Journal of Cancer Prevention

  • 제16권2호
  • /
  • Pages.757-760
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  • 2015
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Rhabdomyosarcoma - an Epidemiological and Histopathologic Study of 277 Cases from a Major Tertiary Care Center in Karachi, Pakistan

  • Ahmad, Zubair (Department of Pathology and Microbiology, Aga Khan University Hospital) ;
  • Din, Nasir Ud (Department of Pathology and Microbiology, Aga Khan University Hospital) ;
  • Ahmad, Arsalan (Department of Pathology and Microbiology, Aga Khan University Hospital) ;
  • Imran, Sheharbano (Department of Pathology and Microbiology, Aga Khan University Hospital) ;
  • Pervez, Shahid (Department of Pathology and Microbiology, Aga Khan University Hospital) ;
  • Ahmed, Rashida (Department of Pathology and Microbiology, Aga Khan University Hospital) ;
  • Kayani, Naila (Department of Pathology and Microbiology, Aga Khan University Hospital)
  • 발행 : 2015.02.25
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초록

Aim: To present the epidemiologic data (age, gender, size etc) and histopathologic and immunohistochemical features of cases of rhabdomyosarcoma (RMS) reported in our department. Settings: Section of Histopathology, Department of Pathology and Microbiology, Aga Khan University Hospital, Karachi, Pakistan. Duration: All cases of RMS diagnosed between January 1, 2003 and December 31, 2012 were included in the study. Results: A total of 277 cases were included. Embryonal rhabdomyosarcoma (ERMS) was by far the dominant histologic type (87.4%) followed by alveolar type (ARMS)(9.4%). ERMS was much more common in males (64.0%)and over 65% of cases occurred in the first decade of life (over 90% in the first two decades). Head and neck region was commonest site for ERMS (46.7%), followed by the genitourinary system (16.1%). Over 65% cases of ARMS occurred in the extremities. Over 80% cases of ARMS occurred in the first 3 decades of life. Immunohistochemical staining for Desmin and MyoD1 was positive in 96.7% and 85.4% respectively. Conclusions: The epidemiologic data and microscopic findings in our patients are similar to international published data on rhabdomyosarcoma.

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참고문헌

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