DOI QR코드

DOI QR Code

Feasibility and Efficacy of Concurrent Chemoradiotherapy in Elderly Patients with Esophageal Squamous Cell Carcinoma: a Respective Study of 116 Cases from a Single Institution

  • Li, Xue (Department of Radiation Oncology and Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer) ;
  • Zhao, Lu-Jun (Department of Radiation Oncology and Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer) ;
  • Liu, Ning-Bo (Department of Radiation Oncology and Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer) ;
  • Zhang, Wen-Cheng (Department of Radiation Oncology and Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer) ;
  • Pang, Qing-Song (Department of Radiation Oncology and Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer) ;
  • Wang, Ping (Department of Radiation Oncology and Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer) ;
  • Yuan, Zhi-Yong (Department of Radiation Oncology and Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer)
  • 발행 : 2015.03.09

초록

Background: To evaluate the safety and efficacy of combined chemoradiotherapy or radiotherapy alone in elderly patients with esophageal carcinoma to identify the best method of treatment. Materials and Methods: One hundred and sixteen patients with esophageal carcinoma aged 70 and older who received definitive radiotherapy or chemoradiotherapy entered the study. Overall survival (OS), disease-free survival (DFS) and treatment-related toxicities were assessed. Results: The median OS of the overall population was 17.9 months. For patients treated with cCRT, sCRT and radiotherapy alone, the median OS was 22.3 months, 18.0 months and 12.4 months respectively(P=0.044). Median OS for patients treated with radiotherapy dose ${\geq}60Gy$ and <60Gy was 20.2 months and 10.9 months respectively (p=0.017). By univariate analysis, Chemoradiotherapy (include cCRT and sCRT) and radiotherapy dose ${\geq}60Gy$ were found to achieve higher survival rates compared with radiotherapy alone and radiotherapy dose <60Gy (P=0.015, P=0.017). By multivariate analysis, chemoradiotherapy (HR=1.645, P=0.022) and radiotherapy dose ${\geq}60Gy$ (HR=1.642, P=0.025) were identified as independent prognostic factors of OS. Conclusions: Definitive concurrent chemoradiotherapy could be considered as a feasible and effective treatment in esophageal carcinoma patients aged 70 and older. Radiotherapy dose 60Gy is an effective treatment option compared with standard dose radiotherapy, while higher doses are not beneficial to improve survival.

키워드

참고문헌

  1. Arias E. (2014). United states life tables, 2009. Natl Vital Stat Rep, 62, 1-63.
  2. Bedenne L, Michel P, Bouche O, et al (2007). Chemoradiation followed by surgery compared with chemoradiation alone in squamous cancer of the esophagus: FFCD 9102. J Clin Oncol, 25, 1160-8. https://doi.org/10.1200/JCO.2005.04.7118
  3. Chen Z, Chen Q, Xia H, Lin J (2011). Green tea drinking habits and esophageal cancer in southern China: a case-control study. Asian Pac J Cancer Prev, 12, 229-33.
  4. D'Journo XB, Thomas PA (2014). Current management of esophageal cancer. J Thorac Dis, 6, 253-64.
  5. Hironaka S, Ohtsu A, Boku N, et al (2003). Nonrandomized comparison between definitive chemoradiotherapy and radical surgery in patients with T (2-3)N (any) M (0) squamous cell carcinoma of the esophagus. Int J Radiat Oncol Biol Phys, 57, 425-33. https://doi.org/10.1016/S0360-3016(03)00585-6
  6. Igissinov N, Tereshkevich D, Moore MA, et al (2011). Age characteristics of incidences of prevalent cancers in the Aral Sea area of Kazakhstan. Asian Pac J Cancer Prev, 12, 2295-7.
  7. Kawashima M, Ikeda H, Yorozu A, et al. (1998). Clinical features of esophageal cancer in the octogenarian treated by definitive radiotherapy: a multi-institutional retrospective survey. Jpn J Clin Oncol, 28, 301-7. https://doi.org/10.1093/jjco/28.5.301
  8. Li G, Hu W, Wang J, et al (2010). Phase II study of concurrent chemoradiation in combination with erlotinib for locally advanced esophageal carcinoma. Int J Radiat Oncol Biol Phys, 78, 1407-12. https://doi.org/10.1016/j.ijrobp.2009.10.012
  9. Liu SZ, Wang B, Zhang F, et al (2013). Incidence, survival and prevalence of esophageal and gastric cancer in Linzhou city from 2003 to 2009. Asian Pac J Cancer Prev, 14, 6031-4. https://doi.org/10.7314/APJCP.2013.14.10.6031
  10. Minsky BD, Pajak TF, Ginsberg RJ, et al (2002). INT 0123 (Radiation Therapy Oncology Group 94-05) phase III trial of combined-modality therapy for esophageal cancer: high-dose versus standard-dose radiation therapy. J Clin Oncol, 20, 1167-74. https://doi.org/10.1200/JCO.20.5.1167
  11. Mirinezhad SK, Somi MH, Seyednezhad F, et al (2013). Survival in patients treated with definitive chemoradiotherapy for non-metastatic esophageal cancer in north- west iran. Asian Pac J Cancer Prev, 14, 1677-80. https://doi.org/10.7314/APJCP.2013.14.3.1677
  12. Mirinezhad SK, Somi MH, Shirmohamadi M, et al (2013). Impact of postoperative chemoradiotherapy and chemoradiotherapy alone for esophageal cancer in North-West Iran. Asian Pac J Cancer Prev, 14, 3921-4. https://doi.org/10.7314/APJCP.2013.14.6.3921
  13. Mountain CF, Dresler CM (1997). Regional lymph node classification for lung cancer staging. Chest, 111, 1718-23. https://doi.org/10.1378/chest.111.6.1718
  14. Nallapareddy S, Wilding GE, Yang G, Iyer R, Javle M (2005). Chemoradiation is a tolerable therapy for older adults with esophageal cancer. Anticancer Res, 25, 3055-60.
  15. Rochigneux P, Resbeut M, Rousseau F, et al (2014). Radio (chemo) therapy in elderly patients with esophageal cancer: a feasible treatment with an outcome consistent with younger patients. Front Oncol, 4, 100.
  16. Shen K, Huang XE, Lu YY, Wu XY, Liu J, Xiang J (2012). Phase II study of docetaxel (Aisu (R)) combined with three- dimensional conformal external beam radiotherapy in treating patients with inoperable esophageal cancer. Asian Pac J Cancer Prev, 13, 6523-6. https://doi.org/10.7314/APJCP.2012.13.12.6523
  17. Stahl M, Walz M K, Stuschke M, et al (2009). Phase III comparison of preoperative chemotherapy compared with chemoradiotherapy in patients with locally advanced adenocarcinoma of the esophagogastric junction. J Clin Oncol, 27, 851-6. https://doi.org/10.1200/JCO.2008.17.0506
  18. Suh YG, Lee IJ, Koom WS, et al (2014). High-dose versus standard-dose radiotherapy with concurrent chemotherapy in stages II-III esophageal cancer. Jpn J Clin Oncol, 44, 534-40. https://doi.org/10.1093/jjco/hyu047
  19. Tougeron D, Di Fiore F, Thureau S, et al (2008). Safety and outcome of definitive chemoradiotherapy in elderly patients with oesophageal cancer. Br J Cancer, 99, 1586-92. https://doi.org/10.1038/sj.bjc.6604749
  20. Uno T, Isobe K, Kawakami H, et al (2004). Efficacy and toxicities of concurrent chemoradiation for elderly patients with esophageal cancer. Anticancer Res, 24, 2483-6.
  21. Xu H Y, ZD, Zhou L, et al (2014). Safety and efficacy of radiation and chemoradiation in patients over 70 years old with inoperable esophageal squamous cell carcinoma. Oncol Lett, 7, 260-6. https://doi.org/10.3892/ol.2013.1694
  22. Yuan P, Chen TH, Chen ZW, Lin XQ. (2014). Calculation of life-time death probability due malignant tumors based on a sampling survey area in China. Asian Pac J Cancer Prev, 15, 4307-9. https://doi.org/10.7314/APJCP.2014.15.10.4307
  23. Zhang Y. (2013). Epidemiology of esophageal cancer. World J Gastroenterol, 19, 5598-606. https://doi.org/10.3748/wjg.v19.i34.5598

피인용 문헌

  1. Feasibility of Elective Nodal Irradiation (ENI) and Involved Field Irradiation (IFI) in Radiotherapy for the Elderly Patients (Aged ≥ 70 Years) with Esophageal Squamous Cell Cancer: A Retrospective Analysis from a Single Institute vol.10, pp.12, 2015, https://doi.org/10.1371/journal.pone.0143007
  2. Clinical outcomes of elderly patients (≥70 years) with resectable esophageal squamous cell carcinoma who underwent esophagectomy or chemoradiotherapy vol.95, pp.50, 2016, https://doi.org/10.1097/MD.0000000000005630
  3. Advanced Age is Not a Contraindication for Treatment With Curative Intent in Esophageal Cancer vol.41, pp.9, 2018, https://doi.org/10.1097/COC.0000000000000390
  4. Aging-related prognosis analysis of definitive radiotherapy for very elderly esophageal cancer vol.7, pp.5, 2018, https://doi.org/10.1002/cam4.1456
  5. Clinical outcome of elderly patients (≥ 70 years) with esophageal cancer undergoing definitive or neoadjuvant radio(chemo)therapy: a retrospective single center analysis vol.13, pp.1, 2018, https://doi.org/10.1186/s13014-018-1044-8
  6. ) and DWI Apparent Diffusion Coefficient as Predictive Markers of Short- and Long-Term Efficacy of Chemoradiotherapy in Patients With Esophageal Cancer vol.17, pp.1533-0338, 2018, https://doi.org/10.1177/1533034618765254
  7. Feasibility and efficiency of concurrent chemoradiotherapy with a single agent or double agents vs radiotherapy alone for elderly patients with esophageal squamous cell carcinoma: Experience of two centers vol.8, pp.1, 2019, https://doi.org/10.1002/cam4.1788